Medicine inspection device, and medicine packaging device

ABSTRACT

A medicine inspection device includes an inspection unit for inspecting a medicine disposed on the inspection unit; a vibrator to impart vibration to the medicine disposed on the inspection unit; and a shooting unit capable of photographing the medicine disposed on the inspection unit. The medicine inspection device further includes a medicine information detector capable of detecting at least the quantity or type of the medicine based on an image obtained by the shooting unit and a distribution detector which is configured to detect a distribution of the medicine on the inspection unit based on the image obtained by the shooting unit. The inspection unit includes a plurality of inspection areas where the vibrator independently provides vibration to each inspection area. The medicine inspection device is characterized by operating the vibrator so as to provide vibration in the inspection areas chosen based on the detection result of the distribution detector.

This application claims priority under 35 U.S.C. §120 as a continuationof U.S. patent application Ser. No. 13/885,674, filed May 15, 2013,which is the national phase entry under 35 U.S.C. §371 of InternationalApplication No. PCT/JP2012/61332, filed on Apr. 27, 2012, which claimspriority under 35 U.S.C. §119 to Japanese Patent Application No. JP2011-100731, filed on Apr. 28, 2011, Japanese Patent Application No. JP2011-213116, filed on Sep. 28, 2011 and Japanese Patent Application No.JP 2011-276455, filed on Dec. 16, 2011, the contents of which are herebyincorporated by reference in their entirety for all purposes.

TECHNICAL FIELD

The present invention relates to a medicine inspection device to inspectthe quantity of a medicine, and a medicine packaging device equippedwith the medicine inspection device.

BACKGROUND ART

Conventionally, medicine dispensing devices such as the one disclosed inthe Japanese Patent Application Publication No. 1995-200770 (hereinafterPatent document 1) are available. In the medicine dispensing devicedisclosed in Patent document 1, solid medicine in form of granular,capsule or the like can be packaged in one package at a time with apackaging paper and supplied. Further, the medicine dispensing device ofPatent document 1 has a configuration, wherein solid medicine is imagedin a state of packaged in the packaging paper, and based on the obtainedimage, the quantity of the solid medicine can be inspected.

Because the medicine dispensing device according to the Patent document1 images solid medicine packaged in a packaging paper, it is likely thatthe imaging is done in a state wherein many solid medicines piled up orin contact with each other in the packaging paper. When inspection ofthe quantity is done based on such an image, there is a high possibilitythat multiple solid medicines may get misidentified as a single mass,and the quantity of the solid medicines cannot be accurately determined.

Therefore, the object of the present invention is to provide a medicineinspection device in which proper inspection of the quantity of solidmedicine is possible without occurrence of inspection failures due tooverlap or contact of the solid medicines or the existence of apackaging paper, and a medicine dispensing device equipped with such amedicine inspection device.

SUMMARY OF THE INVENTION

The medicine inspection device according to the embodiments of thepresent invention includes:

-   -   an inspection unit on which a medicine for inspection is        disposed;    -   a vibrator to impart vibration to the medicine disposed on the        inspection unit;    -   a shooting means capable of photographing the medicine disposed        on the inspection unit;    -   a medicine information detector capable of detecting at least        either of quantity or type or both based on an image obtained by        the shooting means; and    -   a distribution detector that can detect a distribution of the        medicine on the inspection unit based on the image acquired by        the shooting means, wherein the vibrator is configured to        operate based on a result of detection by the distribution        detector.

In the medicine inspection device of the present invention, thedistribution (location and/or amount) of the medicine in the inspectionunit is detected by the distribution detector, and based on the resultof the detection, the vibrator is operated. With this, it is possible toprevent solid medicine for inspection from piling up, contacting, orstanding upright, and the inspection accuracy of a medicine by medicineinformation detector can be improved.

In the medicine inspection device according to the present invention,based on an image of the medicine disposed in the inspection unit takenby the shooting means, the distribution condition of the medicine in theinspection unit is detected by the distribution detector, and vibrationis provided to those inspection areas selected in response to thedistribution condition. Therefore, in the medicine inspection deviceaccording to the present invention, it is possible to provide vibrationsto the exact medicines that are piled up or standing, or in contact witheach other. With this, with the medicine dispersed on the inspectionunit, it becomes possible to detect the medicine quantity or the type orboth by the medicine information detector, and it is extremely effectiveespecially when inspecting a medicine that is packaged in the packagingpaper. Therefore, according to the medicine inspection device of thepresent invention, there will be no inspection failure regardless ofpiling up or contact of the medicine, or presence or absence of packageby the packaging paper, and it becomes possible properly detect eitherthe medicine quantity or the type or both.

Regarding the medicine inspection device of the present inventiondescribed above, the medicine for inspection may also be supplied in astate wherein each prescription is packaged separately in a translucentpackaging paper.

As explained above, in the medicine inspection device according to thepresent invention, it is possible to provide vibration in appropriateinspection areas by the vibrator based on the distribution condition ofa medicine, and therefore, tentatively even if the medicine to beinspected is packaged in a packaging paper, it is possible to dispersethe medicine so as to be suitable for inspection. Therefore, accordingto the medicine inspection device of the present invention, evenmedicine that has been packaged by each dose by a packaging paper, therewill be no inspection failure, and accurate inspection can be carriedout.

In the above-mentioned medicine inspection device of the presentinvention, it is preferable that the vibrator imparts vibration inpreference to the inspection area containing more medicines than otherareas.

In the medicine inspection device of the present invention, vibration isgenerated preferentially in the inspection areas containing a largeamount of medicine than in other inspection areas, and therefore, evenif the medicines are piled up, in an upright state, or in contact witheach other, these medicines can be smoothly and definitely separated,and dispersed into a fallen state. Therefore, in the medicine inspectiondevice of the present invention, there will be no inspection failure dueto the medicines that are piled up or in contact with each other, or inupright state etc.

In the medicine inspection device of the present invention providedbased on similar knowledge, it is further preferable that the vibratorimpart vibration to an inspection area having the largest number ofmedicines, and does not impart vibration in other inspection areas.

In the medicine inspection device of the present invention, it isbelieved that, in the inspection area having the largest amount ofmedicines, there is a high probability that the medicine is unevenlydistributed, and medicines are overlapped with other medicines, incontact with other medicines, or in an upright state. Based on such aconcern, in the medicine inspection device of the present invention, itis made such that vibration is generated in an inspection area havingthe largest amount of medicines, and vibration is not generated in otherinspection areas. With this, even if there are medicines overlapped withother medicines, in contact with other medicines, or in an uprightstate, these medicines can be smoothly and surely separated anddispersed into a fallen state. Therefore, in the medicine inspectiondevice of the present invention, there will be no inspection failure dueto existence of medicine in upright state, a piled up state or incontact with each other.

Here, in case a medicine is unevenly distributed in a predeterminedinspection area, it is preferable that the inspection area for operatingthe vibrator be chosen by taking into account the distributioncondition, and apply vibration. On the other hand, in case the medicineis already well-dispersed even without application of vibration, and isin a state wherein accurate inspection is possible, it is possible tonot only improve the inspection speed by performing the inspectionwithout application of vibration, but also to achieve a rather highaccuracy of inspection. Therefore, it is preferable to provide aconfiguration for accurately judging the need for generating thevibration and appropriately applying vibration based on the result ofthe judgment.

The medicine inspection device of the present invention provided basedon this knowledge includes a vibration controller that can determine theneed for generating vibration based on the distribution condition ofmedicine in the inspection unit detected by the distribution detector,and that can control the operation of the vibrator based on thedetermined result. In the medicine inspection device of the presentinvention, in case the generation of vibration is determined to benecessary by the vibration controller, vibration is generated by thevibrator, and after that, the medicine quantity or type or both can bedetected by the medicine information detector based on an image taken bythe shooting means. In the medicine inspection device of the presentinvention, in case the generation of vibration is determined to beunnecessary by the vibration controller, the medicine quantity or typeor both can be detected by the medicine information detector based on animage taken by the shooting means without generating vibration by thevibrator.

The medicine inspection device of the present invention is provided witha vibration controller that determines the necessity for vibrationgeneration based on the distribution condition of medicine in theinspection unit, and the vibrator can be operated based on thisdetermined result. With this, the medicine inspection device of thepresent invention can appropriately provide vibration when there is aneed to disperse the medicine, and perform an accurate inspection. Also,in the medicine inspection device of the present invention, it isdesigned that vibration is not generated if vibration is determined tobe unnecessary, and the inspection is performed based on an imagecaptured by the shooting means, and therefore, the inspection speed andthe inspection accuracy of the medicine can be further improved.

In the medicine inspection device of the present invention, it ispreferable that the vibrator is provided with a leaf spring, and thatvibration is generated by the elastic force of the leaf spring, and suchleaf springs are provided in each inspection area.

According to this configuration, by vibrating the leaf spring providedin each inspection area, it becomes possible to provide vibrationprecisely to a medicine existing in an inspection area to whichvibration is to be provided.

In the medicine inspection device of the present invention, among theleaf springs, it is further preferable that the leaf springcorresponding to an inspection area determined as not to impartvibration is held down and is made departed from a packaging paper.

According to this configuration, it becomes possible to prevent applyingvibration to the medicine in an inspection area that needs to be anon-vibration state, and to disperse the medicine more precisely andimprove the inspection accuracy.

In the medicine inspection device of the present invention, it ispreferable that the leaf spring includes a fixed part at one end fixedto another member and a free end at another end, and the vibratorincludes a shock imparting means to impart a shock to the free end ofthe leaf spring, and the fixed part is provided in a position departedfrom the inspection area.

In the medicine inspection device of the present invention, by impactingthe free end of a leaf spring by the shock imparting means, it ispossible to vibrate the leaf spring corresponding to an inspection areato be vibrated, and to disperse the medicine. By providing impact onceor several times intermittently to the free end, the vibration providedto a leaf spring becomes a free or gradually attenuated vibration afterthe impact application, and unlike a mechanical vibration addingmechanism that always provides constant vibration, it is possible toprovide an even more appropriate dispersion effect.

Here, as mentioned above, when vibrating a leaf spring by applyingimpact to the free end section, the vibration in the fixed part sidetends to be smaller than the other section. Based on such knowledge, thefixed part is provided at a position away from the inspection area inthe medicine inspection device of the present invention. Therefore, inthe medicine inspection device of the present invention, it is possibleto generate adequate vibration to disperse medicine even in the fixedsection of a leaf spring similarly to the free end section.

In the medicine inspection device of the present invention, it ispreferable to include a lighting device encompassing the inspection areaor a virtual area conceivable in a position departed vertically from theinspection area, and being capable of emitting light in an outer side ofthe inspection area or the virtual area.

In the medicine inspection device of the present invention, a lightingdevice capable of emitting light so as to surround the inspection areaor an imaginary virtual area at a location separated in the verticaldirection from the inspection area, and therefore, a medicine disposedin the inspection unit can be photographed by the shooting means in anexternally illuminated state. With this, it becomes possible tophotograph a medicine in a state wherein the outline can be clearlycaptured. Therefore, in the medicine inspection device of the presentinvention, by processing an image obtained by the shooting means with amedicine information detector, it becomes possible to precisely detecteither the medicine quantity or type or both.

Further, in the medicine inspection device of the present invention, itis preferable to install a diffusion light emitting device capable ofgenerating diffusion light and being provided above the inspection unit.

According to this configuration, a medicine disposed on the inspectionunit can be illuminated without creating a shadow, and it is possible toclearly capture the outline of the medicine, marking on the surface, theprinted characters or the like. With this, the detection accuracy of thequantity or type of a medicine can be further improved.

In the medicine inspection device of the present invention, it ispreferable that the lighting device includes a plurality of lightemitting diodes disposed so as to surround the inspection area or thevirtual area, and the optical axis of the light emitting diodes isdirected towards the inspection area.

In the medicine inspection device of the present invention, lightemitting diodes are used as the light source of the lighting device andtheir optical axes are directed towards the inspection areas, andtherefore, it is possible to irradiate a high intensity light preciselyonto a medicine disposed in an inspection area. Therefore, in themedicine inspection device of the present invention, it becomes possibleto obtain an image clearly capturing the outline of a medicine disposedin an inspection area, and to further improve the inspection accuracy.

In the medicine inspection device of the present invention, it ispreferable to provide a lighting device having a light emitting diode asa light source and being provided in a position departed vertically fromthe inspection area, the light emitting diode being provided outside ofvirtual area conceivable in a position departed vertically from theinspection area, and a light axis of the light emitting diode beingdirected to the inspection area.

In the medicine inspection device of the present invention, a lightingdevice is provided in a vertical direction with respect to theinspection area, and the light emitting diodes that function as thelight source in this lighting device will emit light obliquely from anupper direction towards the inspection area. With this, a medicinedisposed in an inspection area is illuminated, the medicine isphotographed in a state wherein the outline can be captured clearly, andeither the medicine quantity or type or both can be clearly captured bythe medicine information detector. Thus, according to the presentinvention, the inspection accuracy of the medicine inspection device canbe further improved.

In the medicine inspection device of the present invention, it ispreferable to provide a prescription information acquisition means foracquiring at least one of information regarding a quantity based on aprescription regarding a medicine for inspection (legitimateprescription quantity) or a medicine type based on the prescription(legitimate prescription medicine type); and a collation means forcollating the prescription information with detected informationacquired by the prescription information detector.

According to this configuration, by comparing the detected informationobtained by the medicine information detector with the prescriptioninformation, it is possible to accurately find out whether the type orquantity of the medicine is consistent with the legitimate ones.

In the medicine inspection device of the present invention, it ispreferable that medicines are supplied as a continuous array of sachetsformed by packaging one dose of the medicine per sachet in a packagingpaper and aligning the sachets in form of a strip, and each sachet isable to be inspected one by one, and it is preferable that the medicineinspection device further includes: a prescription informationacquisition means capable of capturing the prescription informationbased on an information medium if an information medium has beenprovided to the continuous array of sachets to capture at least one ofinformation regarding the prescribed quantity or prescribed type of themedicine for inspection; and a collation means for collating theprescription information obtained by the prescription informationacquisition means with detected information acquired by the medicineinformation detector.

In the medicine inspection device of the present invention, it ispossible to accurately and smoothly capture the prescription informationbased on the information medium attached to a continuous body of sachetsmade by packaging the medicine in a continuous packaging paper, and theinspection speed and inspection accuracy can be further improved.

The medicine inspection device of the present invention may be connectedto a medicine packaging device, the medicine packaging device including:a medicine supplier capable of supplying a medicine according toprescription; a medicine preparation means capable of storing a medicinesupplied by the medicine supplier by one dose and of dispensing themedicine; a packaging means for packaging each done of medicine suppliedfrom the medicine preparation means; and an outlet for discharging amedicine packaged by the packaging means. Also, the medicine inspectiondevice of the present invention may further include a connector forconnecting with the outlet.

By making it possible for the medicine inspection device of the presentinvention to be connected to the medicine packaging device, theoperations starting from packaging of medicine till inspection can becoordinated with the medicine packaging device, and executed as oneseries of operations. Further, the medicine inspection device of thepresent invention can be also used as a device that operates integrallyin cooperation by providing a connector for connecting to the outletintended for extracting the medicine packaged in the medicine packagingdevice, and using it together with the medicine packaging device.Therefore, according to the medicine inspection device of the presentinvention, the operational efficiency and speed involved in thepackaging and inspection of a medicine can be improved furthermore.

The medicine inspection device of the present invention may have aconfiguration in which medicines are supplied as a continuous array ofsachets formed by packaging one dose of the medicine per sachet in apackaging paper and aligning the sachets in form of a strip, and eachsachet is able to be inspected one by one, and the medicine inspectiondevice may further include a transportation means for delivering thecontinuous array of sachets to the inspection unit while oscillating itin the horizontal direction.

By adopting such a configuration, even if the medicine is assumed tohave been sealed in a sachet in an upright state, or in contact withother medicines etc., the medicine will fall and be dispersed by thetime it reaches the inspection unit because of the oscillation in thehorizontal direction provided by the transportation means. Therefore,according to the present invention, the possibility of applyingvibration to the inspection unit can be kept to a minimum so that thetime required for inspection operation can be furthermore shortened.

Here, when vibrating a sachet by operating the transportation means asdescribed above, if a sachet is heavy because a large quantity ofmedicines are packaged in a sachet or the like, the continuous body ofsachets may slip on the transportation means, and may not be oscillatedwell. Thus, it is possible that a sachet may not be positioned in acorrect inspection position after the vibration, and an accurate imagingand inspection may not be performed.

To resolve such a problem, it is preferable that the medicine inspectiondevice of the present invention has a configuration in which medicinesare supplied as a continuous array of sachets formed by packaging onedose of the medicine per sachet in a packaging paper and aligning thesachets in form of a strip, and each sachet is able to be inspected oneby one, and the medicine inspection device further includes: anintroduction unit for introducing the continuous array of sachets; atransportation means for delivering the continuous array of sachetsintroduced from the introduction unit; and an ejection unit for ejectingthe continuous array having passed through the inspection unit, whereina fixing device capable of stopping a movement of the continuous arrayof sachets by the transportation means to a transportation direction isprovided in the introduction unit or in the ejection unit or in both,and when oscillating the continuous array of sachets in the horizontaldirection, at least one end of the continuous array of sachets isfixable by the fixing device.

By adopting such a configuration, by fixing one end of the continuousbody of sachets by the fixing device, it becomes possible to avoidslipping of the continuous body of sachets on the transportation means,and make it vibrate with certainty. With this, it becomes possible tosustain the function of disposing a sachet in an original correctinspection position.

In the medicine inspection device described above, it is preferable thatthe fixing device is configured to sandwich the continuous array ofsachets.

By adopting such a configuration, the slipping of the continuous arrayof sachets during vibration operation can be surely prevented.

Here, in vibrating a continuous body of sachets as described above, ifthe continuous body of sachets is fixed by the fixing device, excessivestress may get applied to the continuous body of sachets and may resultin damaging it in some cases if the fixing is not done at a properlocation considering the vibration direction.

Based on the above knowledge, in case of the medicine inspection deviceof the present invention described above, it is preferable to have aconfiguration in which, when vibrating the continuous body of sachetsfirst to the introduction unit in performing the vibration operationwith the help of the transportation means for vibrating the continuousbody of sachets in a horizontal direction, the continuous body ofsachets is fixed by the fixing device provided in the introduction unit,and the fixing of the continuous body of sachets by the fixing deviceprovided in the ejection unit is released; and when vibrating thecontinuous body of sachets first to the ejection unit, the continuousbody of sachets is fixed by the fixing device provided in the ejectionunit, and the fixing of the continuous body of sachets by the fixingdevice provided in the introduction unit is released.

As described above, when vibrating a continuous body of sachets, if thefixing location by the fixing device is determined according to thedirection of vibration of the initial movement, it is possible to surelyprevent excessive stress from applying to the continuous body ofsachets, and the continuous body of sachets from being damaged.

Further, the medicine inspection device of the present invention mayhave a configuration wherein medicines are supplied as a continuousarray of sachets formed by packaging one dose of the medicine per sachetin a packaging paper and aligning the sachets in form of a strip, andeach sachet is able to be inspected one by one, and the medicineinspection device further includes: a transportation means fortransferring the continuous array of sachets to the inspection unit; andan upright-state elimination means provided in an upstream side of thetransportation direction of the continuous array of sachets with respectto the inspection unit, wherein the upright-state elimination means hasan arm configured to oscillate along a surface of the continuous arrayof sachets passing through a transportation route of the transportationmeans.

In the medicine inspection device of the present invention, whenconveying a continuous body of sachets by the transportation means, thearm of the upright-state elimination means disposed in the upstream ofthe inspection unit vibrates along the surface of the continuous body ofsachets. With this, the medicine stored in each sachet gets pushed bythe arm and falls down, and reaches the inspection unit in a dispersedstate. Therefore, in the medicine inspection device of the presentinvention, the possibility of applying vibration to the inspection unitto disperse medicine can be kept to a minimum, and the time required forinspection operation can be furthermore shortened.

The medicine inspection device of the present invention may have aconfiguration in which medicines are supplied as a continuous array ofsachets formed by packaging one dose of the medicine per sachet in apackaging paper and aligning the sachets in form of a strip, and eachsachet is able to be inspected one by one, and the medicine inspectiondevice includes: a transportation means for transferring the continuousarray of sachets to the inspection unit; and an upright-stateelimination means provided in an upstream side of the transportationdirection of the continuous array of sachets with respect to theinspection unit. Also, the upright-state elimination means may include:a spindle provided above a transportation route of the transportationmeans and along width direction of transportation route; an arm equippedso that the arm is capable of oscillate around the spindle; and a biasmeans for biasing the arm towards the transportation path so as to letthe arm contact with a continuous array of sachets on the transportationpath.

In the medicine inspection device of the present invention, the arm isprovided to the spindle, which is provided in the upper area of theconveyance path so as to be transverse to the conveyance path, such thatit can oscillate. Therefore, when a continuous body of sachets passesthe conveyance path, the arm oscillates along the surface of thecontinuous body of sachets. With this, the medicine contained in eachsachet is pushed by the arm and falls, and becomes dispersed within thesachet. Therefore, in the medicine inspection device of the presentinvention, dispersion of the medicine within a sachet is acceleratedbefore the sachet reaches the inspection unit, and the need fordispersing the medicine by vibration in the inspection unit can be mademinimum. With this, it also becomes possible to further reduce the timerequired for the inspection operation.

In the medicine inspection device of the present invention, it is alsopossible to have a configuration in which the arm includes a rollercapable of contacting a surface of the continuous array of sachets, andthe roller is provided substantially all along a width direction of thetransportation route formed by the transportation means.

When adopting such a configuration, approximately the whole surfaceregion of each sachet is tracked by the roller, and a medicine that isin an upright state inside a sachet will assume a fallen state.Therefore, by adopting the configuration described above, a medicinecontained inside a sachet can reliably assume a fallen state beforereaching the inspection unit, and deterioration in inspection accuracydue to feeding a medicine in upright state can be prevented.

The medicine inspection device of the present invention may also have aconfiguration, wherein the arm provided in the upright-state eliminationmeans includes a contact part capable of contacting a surface of thecontinuous array of sachets, and the contact part includes: anintroduction-side inclined surface inclining toward an introductionpart; an ejection-side inclined surface inclining toward an ejectionpart; and a medicine leveling unit provided in a boundary between theintroduction-side inclined surface and the ejection-side inclinedsurface, wherein the medicine leveling unit includes: a spindle providedalong a ridge line formed by the introduction-side inclined surface andthe ejection-side inclined surface; and a bead member equipped so as tobe able to oscillate with respect to the spindle.

According to the present invention, by providing an ejection-sideinclined surface and an introduction-side inclined surface, whentransporting a continuous body of sachets from the introduction unitside towards the dispense side (forward direction) by the transportationmeans, and even when transporting the sachets on the opposite direction,the continuous body of sachets can be prevented from climbing on theupright-state elimination means. Also, by further providing a medicineleveling unit of the present invention, it becomes possible for the beadmember to come in good contact with the medicine while moving in theaxial direction, and the bead member can overturn any medicine in anupright state, and makes the medicine easy to be inspected.

The medicine inspection device of the present invention may have aconfiguration in which, medicines are supplied as a continuous array ofsachets formed by packaging one dose of the medicine per sachet in apackaging paper and aligning the sachets in form of a strip, and eachsachet is able to be inspected one by one, and the medicine inspectiondevice includes: a transportation means for transferring the continuousarray of sachets to the inspection unit; and an upright-stateelimination means provided in an upstream side of the transportationdirection of the continuous array of sachets with respect to theinspection unit, and capable of overturning a medicine that is in anupright state inside a sachet by contacting the surface of thecontinuous body of sachets, and wherein if a detection result obtainedby the medicine information detection means for each sachet in thecontinuous array of sachets and the prescription information for thesachet are different, the sachet for which the detection informationdiffers from the prescription information is sent in the reversedirection by the upright-state elimination means and the continuousarray of sachets is reciprocated in a range in which the upright-stateelimination means contacts with the surface of the sachet.

According to this configuration, in case the upright state of themedicine is the cause for the discrepancy between the detection resultobtained by the medicine information detector and the prescriptioninformation, it is possible to solve the upright state of medicine bythe upright-state elimination means, and to perform a re-inspection.With this, the inspection accuracy can be further improved.

In the medicine inspection device of the present invention, in case adetection result obtained by the medicine information detector isdifferent from the prescription information, and only for the case inwhich the detection result obtained by the medicine information detectoris different from the prescription information, it is possible to run acontinuous body of sachets in a reverse direction up to theupright-state elimination means. With this, it becomes possible toenhance the inspection accuracy of the medicine inspection device and toaccelerate the inspection speed.

It is preferable that the medicine inspection device of the presentinvention described above is provided with: an introduction unit forintroducing the continuous array of sachets; a transportation means fordelivering the continuous array of sachets introduced from theintroduction unit; and an ejection unit for ejecting the continuousarray having passed through the inspection unit, and wherein a contactunit that can contact the surface of a continuous body of sachets isprovided on the arm, wherein the arm is provided with a contact unitcapable of touching the surface of a continuous array of sachets, andthe contact unit consists of an introduction side inclined surfaceinclining towards the introduction unit, and a dispense side inclinedsurface inclining towards the ejection unit, and the angle between theconveyance path of the transportation means and the introduction sideinclined surface, and the angle between the conveyance path and thedispense side inclined surface are acute angles.

According to such a configuration, a continuous body of sachets can beprevented from climbing onto the upright-state elimination means whenthe continuous body of sachets is conveyed by a transportation meansfrom the introduction unit in the direction of the dispense side(forward direction), as well as when it is conveyed in a oppositedirection. With this, according to the present invention, it becomespossible to smoothly convey a continuous body of sachets both in forwardand reverse directions. Therefore, according to the present invention,it is possible to accommodate even the operation of transporting acontinuous body of sachets in the reverse direction without any problem.

Here, in the medicine inspection device of the present inventiondescribed above, as a method of supplying a continuous body of sachetsto be inspected in the state of predetermined position with respect tothe inspection unit, a method may be considered in which from theinstant a continuous body of sachets is detected by a sensor providednear the introduction unit, the continuous body of sachets is conveyedonly by a distance equal to the gap between the sensor and theinspection unit. However, when introducing a continuous body of sachetsinto a device, if an operator delays withdrawing the hand etc., asituation may be expected that even if the transportation means isoperated so as to move only by a distance equal to the gap between thesensor and inspection unit following detection of a continuous body ofsachets by an upstream sensor, it may still not be possible to feed acontinuous body of sachets with good accuracy to the inspection unit.

When such a situation is expected, it is desirable that the medicineinspection device has a configuration, wherein medicines are supplied asa continuous array of sachets formed by packaging one dose of themedicine per sachet in a packaging paper and aligning the sachets inform of a strip, and each sachet is able to be inspected one by one, andthe medicine inspection device includes:

a transportation means for transferring the continuous array of sachetsto the inspection unit; an upstream-side sensor provided in upstreamside of the transportation direction of the transportation means withrespect to the inspection unit; and a downstream-side sensor provided indownstream side of the transportation direction of the transportationmeans with respect to the inspection unit, wherein when introducing thecontinuous array of sachets, the continuous array of sachets istransported by the transportation means through a location of theupstream-side sensor and the inspection unit toward a location of thedownstream sensor, and on condition that the continuous array of sachetsis detected by the downstream-side sensor, the transportation means isconfigured to reverse a transportation direction of the continuous arrayof sachets by the transportation means and let the continuous array forinspection to reach the inspection unit.

By adopting such a configuration, even if an operator momentarily delayswithdrawing the hand etc., a sachet can be fed to the inspection unitwith adequate positional accuracy. With this, the inspection accuracycan be further improved.

The medicine inspection device of the present invention may have aconfiguration, wherein medicines are supplied as a continuous array ofsachets formed by packaging one dose of the medicine per sachet in apackaging paper and aligning the sachets in form of a strip, and eachsachet is able to be inspected one by one, and the medicine inspectiondevice includes: a transportation means for transferring the continuousarray of sachets to the inspection unit; and an upright-stateelimination means provided in an upstream side of the transportationdirection of the continuous array of sachets with respect to theinspection unit and capable of oscillating along a surface of thecontinuous array of sachets, wherein the continuous array of sachets istransported to the inspection unit while being oscillated in horizontaldirection, and the upright-state elimination means is configured to falldown a medicine packaged in the sachet in an upright state during atransportation process to the inspection unit.

When using such a configuration, the effect of conveying a continuousbody of sachets while oscillating in the horizontal direction is coupledwith the effect of an upright-state elimination means installed in theconveyance path towards the inspection unit, the medicine packed in eachsachet is definitely supplied in a fallen state to the inspection unit.With this, it becomes possible to minimize a decrease in inspectionaccuracy due to supplying of a medicine in an upright state.

Here, when supplying a sachet in the form of a continuous body ofsachets comprised of a continuous body of sachets in which each dose ofa medicine is packaged as described above, there is a possibility that acontinuous body of sachets may get damaged or cut because tensile forcesgreater than the strength of the continuous body of sachets acts due tothe effect of such as a force exerted by transporting the continuousbody of sachets to the inspection unit, and a force exerted when thecontinuous body of sachets is suspended or pulled towards medicinedispensing device or outside the inspection device. Therefore, whensupplying sachets in the form a continuous body of sachets, it isdesirable to take appropriate measures so that such a situation does notoccur.

Therefore, the medicine inspection device of the present inventionprovided based on the knowledge includes an introduction unit forintroducing a continuous array of sachets formed by packaging one doseof the medicine per sachet in a packaging paper and aligning the sachetsin form of a strip, and each sachet is able to be inspected one by oneby supplying the continuous array of sachets introduced from theintroduction unit to the inspection unit, wherein the introduction unitincludes an introduction unit oscillation member capable of oscillatingvertically and biased toward an upper direction, and the continuousarray of sachet supplied from the introduction unit is configured topass above the introduction unit oscillation member.

When adopting such a configuration, when forces such as acting force dueto conveying of the continuous body of sachets towards the inspectionunit, or a force acting due to suspending of the continuous body ofsachets etc., are acting, it is possible to prevent an excessively largeforce from acting on the continuous body of sachets by oscillating theintroduction unit oscillating member. With this, a damage or breakage ofa continuous body of sachets can be prevented.

It is preferable that the medicine inspection device of the presentinvention has a configuration wherein medicines are supplied as acontinuous array of sachets formed by packaging one dose of the medicineper sachet in a packaging paper and aligning the sachets in form of astrip, and each sachet is able to be inspected one by one, wherein eachof the sachets is sealed with a longitudinal seal part along a widthdirection of the continuous array of sachets and a lateral seal partalong a longer direction of the continuous array of sachets, and whereinthe medicine inspection device includes: a transportation means forconveying a continuous body of sachets to the inspection unit; and atransfer guide disposed on the side of the transportation means, whereinthe transfer guide is provided with a guide roller biased towards theconveyance path and the continuous body of sachets can be conveyed bythe transportation means in a state in which a force is applied to thelateral sealing part by the guide roller.

By adopting such a configuration, it becomes possible to smoothly conveya continuous body of sachets by transportation means, and to preventpassage of guide roller on a medicine packaged in a sachet.

It is preferable that, in the medicine inspection device of the presentinvention, the transfer guide is provided with a support arm formed soas to extend in the direction of transport direction by thetransportation means and to surface-contact the surface of a continuousbody of sachets passing over the conveyance path, and a guide roller isinstalled in the middle of the length direction of the support arm.

By adopting such a configuration, irrespective of whether a continuousbody of sachets is moved in the forward direction or reverse directionby the transportation means, the continuous body of sachets can beprevented from climbing onto the transfer guide. Therefore, according tothe present invention, even the operation of transporting a continuousbody of sachets in the reverse direction can be accommodated without anyproblem.

Here, in order to properly carry out the inspection of a medicinepackaged in a sachet, the sachet shall be preferably disposed in aproper position in the inspection unit. In case sachets are supplied inthe form of a continuous body of sachets wherein several sachets arejoined, if a sachet is not positioned accurately with respect to theinspection unit, there may be a possibility that a medicine inside asachet cannot be identified, or a failure such as a medicine in a sachetthat is adjacent to a sachet to be inspected being accidentallydetected. Therefore, when a medicine to be inspected is supplied as asachet in the form of a continuous body of sachets, it is preferable tohave a configuration wherein each sachet can be disposed with a highpositioning accuracy.

Thereupon, the medicine inspection device of the present inventionprovided based on the knowledge has a configuration wherein medicinesare supplied as a continuous array of sachets formed by packaging onedose of the medicine per sachet in a packaging paper and aligning thesachets in form of a strip, and each sachet is able to be inspected oneby one, wherein each of the sachets is sealed with a longitudinal sealpart along a width direction of the continuous array of sachets and alateral seal part along a longer direction of the continuous array ofsachets, and a boundary is formed between longitudinal seal parts ofneighboring sachets in the continuous array of sachets, and wherein themedicine inspection device further includes: an imaging means fordetecting position provided so as to be able to photograph thelongitudinal seal part located at both sides of the boundary in a longerdirection of the continuous array of sachets, the imaging means capableof photographing the supplied continuous array of sachets in apredetermined position: a longitudinal seal position detecting meanscapable of obtaining a location information of each longitudinal sealpart appearing in an image area photographed by the imaging means fordetecting position; a boundary position detection means capable ofderiving position of the boundary by calculating an intermediate valueof position information of each of longitudinal seal parts detected bythe longitudinal seal position detecting means; and a positionidentification means for identifying position of sachet with respect tothe inspection unit based on position of the boundary derived by theboundary position detection means.

In the medicine inspection device of the present invention, thepositional information of each longitudinal seal part contained in animage photographed by the imaging means for detecting position isdetected by longitudinal seal position detecting means, and from theintermediate value of this positional information, the boundary of twocontinuous sachets can be identified. Therefore, in the medicineinspection device of the present invention, based on the identifiedresult of boundary position of sachets, it is possible to performpositioning of a sachet to be inspected, and thereby achieve animprovement in the inspection accuracy.

Further, the imaging means for detecting position used in the presentinvention may be same as a shooting means (hereafter also referred to as‘imaging means for medicine imaging’) provided for photographing themedicine disposed in the inspection unit, or may also be different fromthe shooting means for medicine imaging. If the imaging means fordetecting position is same as the shooting means for medicine imaging,it becomes possible to simplify the device configuration. If the imagingmeans for detecting position is provided separately from the shootingmeans for medicine imaging, the position of a longitudinal sealing partcan be detected in any position, and the flexibility of device designwill improve.

The medicine inspection device of the present invention has aconfiguration wherein a medicine is supplied in form of continuous arrayof sachets in which a plurality of sachets are aligned in form of astrip and each of the sachets is formed by sealing packaging paper, anda longitudinal seal part is provided at least between neighboringsachets, and a dot-shaped seal trace is formed in the longitudinal sealpart, and each sachet is able to be inspected one by one, and whereinthe medicine inspection device further includes: a boundary positiondetection means capable of deriving a position of the boundary, whereinthe boundary position detection means is configured to derive theposition of the boundary by implementing: an outline detection processfor detecting an outline present in an image area of the sachetsphotographed by the shooting means; an outline expansion process forexpanding a detected area surrounded by an outline detected by theoutline detection process toward outside in a predetermined amount; alongitudinal seal area detection process for detecting a longitudinalarea, the longitudinal area being an area comprising a plurality ofdetected areas which is mutually overlapped by expansion in an imageafter the outline expansion process, and the longitudinal areaelongating along a longitudinal seal direction; and a boundary positionderivation process for deriving an intermediate position of thelongitudinal seal area as a position of the boundary.

In the medicine inspection device of the present invention, by detectingthe longitudinal sealing area as described above, the region where acontinuous body of sachets was vertically sealed can be identified, andthe boundary position of the adjoining sachet can be identified.

In the present invention, by expanding an outline towards the outside ofa detection area by an outline expansion process and mutuallyoverlapping a plurality of detection areas, it is possible to improvethe accuracy of identifying whether the outline and detection areadetected in the outline detection process is due to dot-shaped seal markof the longitudinal sealing part or due to a medicine.

That is, a detection area corresponding to seal mark of a longitudinalsealing part is a series of areas (corresponding to longitudinal sealingregion) overlapped by the outline expansion process and extending in thewidth direction (longitudinal sealing direction) of a continuous body ofsachets. On the other hand, when the outline expansion process isexecuted, though the area of detection for the medicine expands into ashape that approximates the exterior shape of the medicine, it isusually thought it will not become a region of shape like thelongitudinal seal region extending in the width direction of thecontinuous body of sachets.

In light of such a characteristic, in the present invention, byperforming an outline expansion process in addition to outline detectionprocess, it has been made possible to accurately detect the longitudinalsealing part even under the presence of medicine, and therefore, itbecomes possible to detect the position of a longitudinal sealed region(longitudinal sealing region) with excellent accuracy. Therefore, in themedicine inspection device of the present invention, the position of theboundary formed between the sachets can be detected with very highaccuracy.

It is preferable that the medicine inspection device of the presentinvention described above has a configuration wherein a content imageremoval process is implemented before the longitudinal seal areadetection process and content packaged in packaging paper is recognizedbased on luminance information and/or color information of an image forderiving a position of the boundary and image information correspondingto the content is removed.

According to the present invention, it is configured such that a contentin a sachet is identified based on the brightness information and/orcolor information of an image used for deriving the position of theboundary, the section where the content is present is excluded, and thenthe operation for deriving the boundary position is executed, andtherefore, the possibility of erroneously detecting the outline of thecontent as the outline of the longitudinal sealing part can beminimized. With this, the detection accuracy of boundary formed betweenadjacent sachets can be further improved.

Further, the medicine inspection device of the present invention mayhave a configuration wherein medicines are supplied as a continuousarray of sachets formed by packaging one dose of the medicine per sachetin a packaging paper and aligning the sachets in form of a strip, andeach sachet is able to be inspected one by one, wherein each of thesachets is sealed with a longitudinal seal part along a width directionof the continuous array of sachets and a lateral seal part along alonger direction of the continuous array of sachets, and a boundary isformed between longitudinal seal parts of neighboring sachets in thecontinuous array of sachets, the medicine inspection device furtherincludes a boundary position detection means capable of derivingposition of the boundary, wherein the boundary position detection meansis configured to implement: a longitudinal edge detection process fordetecting the longitudinal edge, the longitudinal edge being an outlineelongating longitudinally in an image area of the sachets photographedby the shooting means; a longitudinal edge selection process forselecting a longitudinal edge longer than a predetermined length fromthe longitudinal edge derived from the longitudinal edge detectionprocess; an edge area recognition process for recognizing an area wherea distance between longitudinal edges selected by the longitudinal edgeselection process is equal to or shorter than a predetermined distanceset based on a width of longitudinal seal part; and a boundary positionrecognition process for recognizing a central part of the edge arearecognized by the edge area recognition process as a boundary positionbetween the longitudinal seal parts.

In the medicine inspection device of the present invention, alongitudinal sealing part and a boundary formed between longitudinalsealing parts can be detected as a vertical edge that extends in thevertical direction and exceeds a predetermined length, and the boundarycan be derived by focusing on the unique characteristic of thecontinuous body of sachets in which the longitudinal edge correspondingto the longitudinal sealing part and boundary is located within apredetermined interval. Due to focusing on such a characteristic,compared to the case of deriving the boundary by a simple imageanalysis, the boundary position can be derived easily and accurately.

Here, when processing a large number of prescriptions together, the caseof packaging a medicine in the form of so-called continuousprescriptions etc., the medicines are also packed wherein a medicine ispackaged as a series of former-dose sachets and sachets of latter-dosesachets. Further, when packaging a medicine in such a packaging form,empty sachets in which the medicine is not packaged may be provided inthe middle section of the continuous body of sachets. Furthermore, whenan empty sachet is formed, distinguishing mark such as bar code may alsobe attached on an empty sachet.

As described above, when empty sachets are formed in the middle of acontinuous body of sachets, in order to maintain the inspectionoperation of the medicine with good accuracy, a medicine-containingsachet that is formed next to an empty sachet should be sent to theinspection unit and must be positioned with good accuracy. Therefore,when adopting a medicine inspection device configuration wherein it ispossible to supply a continuous body of sachets provided with emptysachets, it is preferable to take a measure to improve the positioningaccuracy of a sachet containing medicine adjacent to an empty sachet(that is, existing on the downstream of the empty sachet) with respectto the inspection unit.

The medicine inspection device of the present invention provided basedon the knowledge has a configuration wherein medicines are supplied as acontinuous array of sachets formed by packaging one dose of the medicineper sachet in a packaging paper and aligning the sachets in form of astrip; a vacant sachet not containing medicine is provided in anintermediate part of the continuous array of sachets; an identificationmark is put on a predetermined position of the vacant sachet; and eachsachet is able to be inspected one by one, and the medicine inspectiondevice further includes an identification mark recognition means capableof recognizing the identification mark having arrived at a predeterminedreadout position present in the inspection unit or an upstream side ofsupply direction of the continuous array of sachets from the inspectionunit, wherein a sachet containing medicine and positioned in adownstream side of the vacant sachet is locatable against the inspectionunit based on the recognition position where the identification mark isrecognized by the identification mark recognition means.

In the medicine inspection device of the present invention, by having anidentified position in which an identification mark, which is providedon an empty sachet formed in the middle of a continuous body of sachets,is identified by identification mark recognition means as a reference,it is possible to perform positioning of a sachet containing medicinefollowing an empty sachet and the inspection unit with excellentaccuracy. Therefore, in the medicine inspection device of the presentinvention, even for a case of such as forming empty sachet in the middleof a continuous body of sachets for continuous prescription etc., withregard to a medicine-filled sachet existing in the downstream of theempty sachet, it becomes possible to avoid lowering in the inspectionaccuracy due to a reduction in the positioning accuracy with theinspection unit.

The medicine inspection device of the present invention has aconfiguration of including: an inspection unit on which a medicine forinspection is disposed, the medicine being contained in a sachet; ashooting means capable of photographing the sachet disposed on theinspection unit; and a medicine information detector capable ofdetecting at least either of a quantity or type of the medicine based onan image obtained by the shooting means; wherein the inspection unitcomprises a backlight capable of illuminating the sachet from backsidewhen photographing, the backlight comprising illumination areas locateddottedly per predetermined pitch, and wherein the medicine informationdetector is configured to implement: a basic image acquisition processfor acquiring a basic image for medicine inspection based on a back litimage photographed by illuminating the packaging paper from behind bythe backlight; an inspection area defining process for defining the areafor inspection by executing a exclusion process of excluding thedot-shaped translucent region contained in the basic image obtained inthe basic image acquisition process; an inspection image acquisitionprocess for acquiring the inspection image by extracting an areacorresponding to the area for inspection from a back unlit imageobtained by photographing same region as the back lit image in a statewhere the backlight is unlit; and an image inspection process forperforming image inspection to detect the medicine quantity or type orboth based on the inspection image.

In the medicine inspection device of the present invention, in the basicimage acquisition process, a basic image is acquired for medicineinspection on the basis of a back lit image obtained by photographing asachet disposed in the inspection unit in an illuminated state by thebacklight. Here, the backlight used in the present invention can emitlight in a dot-shape. Therefore, in a basic image, a region where themedicine is assumed to be present is photographed as a shadow in thebasic image, and the other region is photographed as a region where thelight is transmitted in a dot-shape (translucent region). Also, in thepresent invention, the inspection area defining process includes aprocess wherein a region through which the dot shaped light istransmitted is excluded from the basic image, and the remaining area isidentified as the region for inspection. Thus, by executing basic imageacquisition process and inspection area defining process, it is possibleto narrow down a region where the medicine is assumed to be present as aregion for inspection. With this, it becomes possible to minimize theexecution load of the image inspection process, and thereby improve thedetection speed of the type and/or quantity of a medicine through imageinspection.

It is preferable that the medicine inspection device of the presentinvention described above has a configuration wherein the backlightcomprises a light source, and a mesh member disposed between the lightsource and the sachet and having perforations through which light passesthrough at each predetermined pitch.

According to such a configuration, it becomes possible to easily andreliably emit light in dot shape at every predetermined pitch over theentire illumination area.

More often, information such as name of the prescribed patient, dosagemethod of the medicine etc., is printed as characters or patterns on thepackaging paper in which a medicine is packaged. When a sachet havingprintings on the packaging paper is supplied for inspection, thecharacters or the like that are printed on the packaging paper coexistin the basic image, and differentiation of medicine present region andprinted area may become difficult. Therefore, when supplying a medicinein a printed packaging paper is assumed, it is desirable to devisemeasures so that a medicine present region and printed area can beeasily and reliably differentiated.

Therefore, the medicine inspection device of the present inventionprovided based on the above knowledge has a configuration wherein amedicine packaged in a printed packaging paper is able to be suppliedfor the inspection unit as a medicine for inspection, and the medicineinformation detection means is capable of executing an image processingto vary size of a region surrounded by outline in the basic image, andas a result of such image processing if a continuous region is formedwherein a region surrounded by the outline is contiguous, the medicineinformation detection means is capable of executing a printed areaexclusion process for excluding an area containing the said continuousregion as printed area from the inspection region.

In case where printing has been done on a packaging paper as describedabove, in the basic image obtained by photographing the packaging paperby emitting light in a dot pattern with the backlight, the light isblocked in a region where the medicine is present thereby forming ashadow, and it is photographed such that the outline of the outer edgeof the medicine can be recognized. On the other hand, as for the areathat has printings on the packaging paper (print area), it isphotographed in a state where the outline can be captured similarly tothe shadow in the basic image, but the area is photographed in a statewhere the light is transmitted in a dot pattern. That is, in the printarea, the section through which the light is transmitted in a dotpattern (translucent region) is photographed such that the outer edge oftranslucent region is captured as an outline.

If an outline contained in the basic image is expanded by imageprocessing, the translucent region aligned in dot pattern in the basicimage join and form a series of regions (contiguous region). Therefore,a contiguous region formed by executing image processing for varying(expanding or contracting) the outline in the basic image can beconsidered as a print area.

The present invention is provided focusing on such a phenomenon. In thepresent invention, when a contiguous region is detected by the expansionor contraction of a region surrounded by outline in the basic image, aregion containing this contiguous region is considered as a printed areaon the packaging paper (print area), and therefore, this region isexcluded from the inspection area. Therefore, in the medicine inspectiondevice of the present invention, even when a packaging paper that isprinted with such as characters etc., is supplied, the medicine quantityor type or both can be derived accurately and rapidly without anyinterference by the printing.

The medicine inspection device of the present invention includes: aninspection unit on which a medicine for inspection is disposed, themedicine being contained in a sachet; a shooting means capable ofphotographing the sachet disposed on the inspection unit; and a medicineinformation detector capable of detecting at least either of a quantityor type of the medicine based on an image obtained by the shootingmeans; wherein the inspection unit includes a backlight capable ofilluminating the sachet from backside when photographing, the backlightincluding illumination areas located dottedly per predetermined pitch,and wherein the medicine information detector is configured toimplement: a basic image acquisition process for acquiring a basic imagefor medicine inspection based on a back lit image photographed byilluminating the packaging paper from behind by the backlight; a grayscale image acquisition process for acquiring a gray scale image bygray-scaling the basic image; a gray morphology treatment process,wherein at least one channel image from among the basic R channel image,basic G channel image and basic B channel image that were obtained byRGB resolution of the basic image is subjected to a gray morphologytreatment to be acquired as an image for identifying a region forexclusion; an inspection region defining process for defining the areafor inspection by executing a exclusion process of excluding a regionfor exclusion determined by the image for identifying a region forexclusion to the gray scale image; an inspection image acquisitionprocess for acquiring the inspection image by extracting an areacorresponding to the area for inspection from a back unlit imageobtained by photographing same region as the back lit image in a statewhere the backlight is unlit; and an image inspection process forperforming image inspection to detect the medicine quantity or type orboth based on the inspection image.

According to this configuration, the probability of a printed area on asachet getting included in an image for inspection can be minimized.With this, the inspection accuracy and inspection speed for the medicinecan be improved.

Here, in the medicine inspection device of the present inventiondescribed above, when executing the image inspection process, it isnecessary to extract the outline of the medicine present in the imageused for inspection. Here, in cases when the background color of thebasic image processed image obtained by processing the basic image andthe color of the medicine are same, derivation of outline of a medicinemay be difficult by only using the basic image processed image.

The medicine inspection device of the present invention provided inorder to solve such a problem has a configuration wherein in the imageinspection process, a contour of a medicine existing in a sachet is ableto be identified by executing composite image edge extraction process toextract an edge contained in a composite image formed by superposing abasic image processed image obtained through an exclusion process inwhich a dotted translucent region in a basic image acquired in the basicimage acquisition process, a brightness map image showing a distributionof brightness in the back unlit image, and a saturation map imageshowing a distribution of the saturation component in the back unlitimage in the image inspection process.

As in the present invention, by using a composite image obtained bysuperposing a basic image processed image, a brightness map image and asaturation map image, it is also possible to extract the outline of amedicine from the perspective of brightness and saturation. Thus, evenif the background color of the basic image processed image is same ascolor of a medicine, it is possible to not only accurately and smoothlyderive the outline of the medicine, but also improve the imageinspection accuracy.

The medicine inspection device of the present invention may have aconfiguration wherein the image inspection process is configured toexecute: an acquisition of a basic image processed image wherein aninspection area contained in the basic image has been extracted; anacquisition of a HSV resolution image for inspection comprising at leastone from among a back unlit H channel image, a back unlit S channelimage and a back unlit V channel image that were obtained by a HSVresolution of the back unlit image; and an acquisition of a singlechannel image for inspection comprising at least one from among a backunlit R channel image, a back unlit G channel image and a back unlit Bchannel image that were obtained by an RGB resolution of the back unlitimage, wherein the image inspection process is also configured toexecute composite image edge extraction process to extract an edgecontained in a composite image formed by superposing the basic imageprocessed image, the HSV resolution image for inspection and the singlechannel image for inspection in order to identify a contour of amedicine existing in a sachet.

In the image inspection device of the present invention, in addition tothe basic image processed image, it is also possible to extract the edgeof a medicine corresponding to outer edge of medicine from theperspective of HSV resolution image for inspection and single channelimage for inspection, and to identify the contour of a medicine. Thus,it becomes possible to further improve the identification accuracy ofthe outline of a medicine, and quickly execute the inspection of themedicine with high accuracy.

Furthermore, the medicine inspection device of the present invention mayhave a configuration wherein, when acquiring the HSV resolution imagefor inspection, a back unlit H channel image is selected as a HSVresolution image for inspection on a condition that a background colorof the sachet during acquisition of the basic image and a color of themedicine packaged in the sachet are similar, and a back unlit S channelimage is selected as a HSV resolution image for inspection on acondition that a background color of the sachet and a color of themedicine packaged in the sachet are different.

In the present invention, an HSV image for inspection is acquiredconsidering the relation between the color of a medicine and thebackground color. Specifically, if a medicine is of same color asbackground color, because of a high possibility of the difference in huebetween the medicine and the background getting manifested strongly, theback unlit H channel image is chosen as a HSV resolution image forinspection. On the other hand, if a medicine is of a color that isdifferent from the background color, because of a possibility of thedifference in saturation getting manifested strongly, the back unlit Schannel image is chosen as an HSV resolution image for inspection.Therefore, according to the present invention, the identificationaccuracy of contour of a medicine and the inspection accuracy of themedicine can be further improved.

The medicine inspection device of the present invention may have aconfiguration wherein when acquiring the single channel image forinspection, from among a back unlit R channel image, back unlit Gchannel image and back unlit B channel image that were obtained by RGBresolution of the back unlit image, the image having highest contrastbetween the inspection area and the non-inspection area is selected as asingle channel image for inspection.

The present invention reflects the results of extensive studies by theinventors that led to a finding that, by selecting an image having thehighest contrast between inspection area and non-inspection area fromamong the back unlit R channel image, back unlit G channel image andback unlit B channel image, the detection accuracy of the edgecorresponding to the contour of a medicine can be improved. Thus, byfocusing on the contrast between inspection area and non-inspection areaaccording to the present invention, and selecting that with highestcontract as a single channel image for inspection, the identificationaccuracy of contour of a medicine and the inspection accuracy of themedicine can be further improved.

It is desirable that the medicine inspection device of the presentinvention described above has a configuration wherein a composite imageedge extraction process is executed on condition that the backgroundcolor of the sachet during acquisition of the basic image and the colorof the medicine packaged in the sachet are similar.

The composite image edge extraction process, as described above, isoptimal when the background color of the basic image and the color ofthe medicine are of similar color. Therefore, according to the presentinvention, the accuracy of image inspection can be further improved.

It is desirable that the medicine inspection device of the presentinvention described above has a configuration wherein the backlight isconfigured to generate red light or a light of a longer wavelength thanred.

In the present invention, since red light or a light having a wavelengthlonger than the wavelength of red is generated and used, the lightgenerated by the backlight has a high linearity. Therefore, in themedicine inspection device of the present invention, the region where amedicine exists and the outline of the medicine can be clearlyrecognized in the basic image.

In addition, even for a case where a packaging paper has printings asdescribed above, it is possible to ensure that the light generated by abacklight is transmitted through the print area. Therefore, as explainedabove, when executing a process for excluding a print area based on thesection through which the light in dot pattern (transmission area) istransmitted in the basic image, by using a backlight capable ofgenerating red light or a light having a high linearity that has awavelength longer than red, it becomes possible to not only improve theexclusion accuracy of excluding a print area from the inspection area,but also to improve the inspection accuracy of a medicine.

It is preferable that the medicine inspection device of the presentinvention described above further includes: a medicine present areadefining means for determining the medicine present area in a medicineregion identification image obtained by photographing a sachet disposedin the inspection unit with the shooting means; and a foreign objectdetection process for detecting a foreign object existing in the sachetbased on an image for position recognition containing position signsprovided with coordinates for each predetermined pitch, and a basicimage acquired by the medicine information detector; wherein the foreignobject detection process is configured to implement: an object existencearea coordinate extraction process for extracting a position coordinatesexisting in a region determined by the inspection area defining processby superposing the image for position recognition and basic image, amedicine coordinates group derivation process for extracting positioncoordinates existing inside a medicine-existing area defined by themedicine present area defining means by superposing an image formedicine area determination and the basic image; and a foreign objectdetermination process for judging a presence of a foreign object incoordinate position on condition that coordinates that are differentfrom the medicine area coordinates group are existing in the objectexistence area coordinates group.

In the medicine inspection device of the present invention, by executingan object existence area coordinate extraction process, an area whereitems such as medicines etc. exist can be obtained as a coordinatesgroup (object existence area coordinates group) from the outlinecontained in a basic image. In addition, by separately executing amedicine coordinate group derivation process, an area where a medicineexists can be obtained as a coordinates group (medicine area coordinatesgroup). In the medicine inspection device of the present invention, inthe foreign object determination treatment process, it is checkedwhether the object existence area coordinates group and the medicinearea coordinates group are identical, and if not so, it is inferred thata foreign object other than the medicine is present inside the sachet.Therefore, according to the medicine inspection device of the presentinvention, not only the inspection of the quantity or type of amedicine, but the co-existence of a foreign object other than medicinecan be reliably detected.

It is preferable that the medicine inspection device of the presentinvention has a configuration wherein in the inspection area definingprocess, an expansion process is executed for expanding an area remainedafter an execution of elimination process by a predetermined amounttowards the outside.

In the present invention, in the inspection area defining process, theexpansion process is performed after the elimination process, andtherefore, an accidental elimination of a medicine-existing area fromthe inspection area due to exclusion process can be prevented. Withthis, the accuracy of medicine inspection can be further improved.

The medicine inspection device of the present invention has aconfiguration wherein an image of a medicine provided on the inspectionunit is able to be clipped by use of a back lit image obtained byphotographing with the imaging means in a irradiated state wherein theinspection unit is irradiated by the backlight and a back unlit imageobtained by photographing by the imaging means in a back non-irradiatedstate wherein the inspection unit is not irradiated by the backlight,and an image of medicine provided on an inspection unit is able to beobtained by: acquiring a back lit binary image by binarization of a backlit RGB resolution image comprising at least one from among the back litR channel image, back lit G channel image and back lit B channel imageobtained from the RGB resolution of the back lit image, assuming anintensity distribution of medicine and the back lit image in the saidback lit binary image to be a Gaussian distribution, deriving mean valueMm and standard deviation σm of the intensity distribution correspondingto the medicine, and the mean value Mb and standard deviation σb of theintensity distribution corresponding to the back image; creating a maskfor medicine image clipping for masking a region of an intensity higherthan the intensity Mm+3σm on condition that Mm+3σm≧Mb−3σb; creating amask for medicine image clipping for masking a region of an intensityhigher than the intensity Mb−3σb on condition that Mm+3σm<Mb−3σb; andclipping a back unlit image based on the mask for medicine imageclipping.

The present inventors, as a result of extensive studies, discovered thatthe region corresponding to the medicine in the back lit binary imagethat is obtained by binarizing the back lit RGB resolution image, andthe brightness distribution of the region corresponding to thebackground can be approximated to Gaussian distribution. The inventorsfurther discovered that the brightness of a region corresponding to themedicine is lower than the brightness of a region corresponding to thebackground, and have mutually different characteristics.

Based on the findings, in the present invention, the mean value Mm ofthe brightness distribution and standard deviation σm for a regioncorresponding to the medicine, and the mean value Mb of the brightnessdistribution and the standard deviation σb for a region corresponding tothe background image are derived, and based on their values, the regioncorresponding to the medicine is identified. That is, with Mm+3σm≧Mb−3σbas a condition, a medicine image cut-out mask is formed to mask a regionwhose brightness is greater than brightness Mm+3σm, and withMm+3σm<Mb−3σb as a condition, a medicine image cut-out mask is formed tomask a region that has brightness greater than brightness Mb−3σb. Bycutting out a back unlit image based on the medicine image cut-out maskset as above, the image of a medicine disposed in the inspection unitcan be acquired without leak, and inspection accuracy can be improvedeven more.

In the medicine inspection device of the present invention describedabove, it is preferable to further include a photographing jigcomprising a translucent stage, wherein the photographing jig with themedicine to be photographed disposed on the stage is moved to theinspection unit, a contour line of the medicine is derived based on theback lit image obtained by photographing with the shooting means in anirradiation state where the stage is irradiated by the backlight, in theback unlit image obtained by photographing the jig disposed in theinspection unit by the imaging means in a non-irradiated state whereinthe stage is not irradiated by the backlight, the device is able toconstruct a contour image database by accumulating appearance imagesshowing external appearance of the medicine obtained by clipping aregion corresponding to a region surrounded by the contour line of themedicine derived based on the back lit image.

In the present invention, in the back lit image photographed in anirradiated state, since a medicine is photographed as a shadow, it ispossible to distinctly and reliably detect the outline of a medicine. Incontrast to this, in an image where a back unlit image was acquiredseparately by photographing in a back unlit state, it will be differentfrom the back lit image, and for a medicine that was clearly included,the outline may not be evident. In the present invention, based on theback lit image, a region for cutting out the image of a medicine isdefined by the outline, and a section corresponding to the regionsurrounded by the outline is cutout from the back unlit image.Accordingly, a region in the back unlit image where a medicine isincluded can be cutout properly (i.e. neither more nor less). Therefore,according to the present invention, a vivid contour image of a medicinecan be acquired easily and with high accuracy, and a contour imagedatabase can be created.

In the medicine inspection device of the present invention describedabove, it is desirable that the stage includes a plurality of imagingzones associated with each side of a medicine, and a medicine isarranged in each imaging area such that a side associated with eachimaging area is orienting towards the imaging means, and by using a backlit image and back unlit image obtained when the imaging jig is moved tothe inspection unit, a database is created by storing a contour image ofeach side of the medicine.

According to such a configuration, the contour image of each side of amedicine can be photographed at once, and a contour image database canbe created.

In the medicine inspection device of the present invention describedabove, it is desirable that an installation guide is provided in stageto facilitate disposing a medicine in a predetermined location, and sizeof the installation guide is smaller than presumed size of a medicineand foreign object.

By installing positioning guides in a stage according to the presentinvention, when photographing a medicine for the purpose of creating acontour image database, a medicine can be guided to be placed in anappropriate place. Also, by setting size of the positioning guides to besmaller than the size of the medicine and a substance thought to be aforeign object as in present invention, in an image photographed forconstruction of a contour image database, identification of positioningguide and medicine becomes easy, and an imaging processing can beexecuted to prevent a positioning guide from getting imaged in thecontour image of the medicine.

In the medicine inspection device of the present invention describedabove, it is preferable that a color of the stage is white.

By making the color of the stage white as in the present invention, forexample, even for medicines that are of green color or of dark colorsuch as black color etc., in an image photographed for contour imageacquisition, the stage and the medicine can be clearly distinguished.With this, the contour image of a medicine can be acquired easily andaccurately, and thereby the accuracy of the contour image database canbe improved.

In the medicine inspection device of the present invention describedabove, it is desirable that the shooting means includes imaging meansfor back lit image for imaging a back lit image, and an imaging meansfor back unlit image for imaging a back unlit image.

In the medicine inspection device of the present invention, a shootingmeans for back lit image and a shooting means for back unlit image areprovided separately. With this, the back lit image and back unlit imagecan be acquired under optimal conditions. Thus, according to the presentinvention, a better contour image database can be created with moreclear and appropriate contour images.

In the medicine inspection device of the present invention describedabove, it is desirable to include a medicine database for inspection inwhich master contour images showing at least the shapes of medicinesthat is able to be inspected are stored, wherein the device is capableof carrying out image inspection by matching an outside shape inspectionimage with a contour image of the medicine present in a sachet, andamong the master contour images registered in the medicine database forinspection, by dividing a master contour image showing a complete shapeof the medicine by a dividing line passing through middle of themedicine area corresponding to the medicine as boundary, a mastercontour image is able to be acquired for a divided medicine obtained bydividing the medicine, and registered in the medicine database forinspection.

According to this configuration, a master contour image for inspectionof a tablet medicine divided by such as cutter etc., can be acquiredeasily and accurately, and create a medicine database for inspection.

Here, in dividing a medicine by such as cutter etc., it is not limitedto cutting with a high accuracy without much deviating from the centerof the medicine, and it is possible to cut in a position much away fromthe center but within the range that will not create problem withdosage. It is desirable to easily create an appropriate medicinedatabase for inspection to facilitate inspection without causing anyerror even for a case when a medicine that has been cut in a positionsomewhat away from the center exists in a sachet.

To deal with such issue, in the medicine inspection device of thepresent invention, it is desirable that, with the dividing line asreference, an image obtained by dividing a master contour image with animaginary quasi-dividing line as boundary at a location separated by apredetermined interval, is able to be added as a master contour imagefor the divided medicine.

By adopting such a configuration, a master contour image can be easilyacquired even for a divided medicine that has been cut at a positionslightly away from the center, and registered in the medicine databasefor inspection. Thus, according to the present invention, the inspectionaccuracy for the divided medicine can be further improved.

The medicine inspection device of the present invention may have aconfiguration wherein medicine division groove included in a medicine isidentified in the master contour image, and a dividing line isdetermined on the basis of the medicine division groove contained in themaster contour image.

According to this configuration, a divided tablet master contour imagefor the purpose of creating a medicine database for inspection orcontour image database can be easily and accurately acquired.

In the medicine inspection device of the present invention, it ispreferable that, after determining the dividing line with reference tothe medicine division groove contained in the master contour image, themaster contour image is rotated around the center of gravity of amedicine region with reference to the said dividing line, and in asituation where a shape of the medicine region present on one side and ashape of the region that is present on the other side with respect tothe dividing line are symmetrical, by dividing the master contour imagewith the dividing line as reference, a master contour image of thedivided medicine is obtained.

According to this configuration, while making the medicine divisiongroove formed in the medicine as reference, the division position of themaster contour image due to the dividing line can be slightly corrected.With this, it becomes possible to obtain the master contour image of adivided medicine with still higher accuracy. Moreover, when rotating amaster contour image in this invention, it is desirable to rotate by asmall angle in both forward and opposite directions using as basis thedividing line around the center of gravity of the of the medicineregion.

Further, in the medicine inspection device of the present invention, itis desirable that, by dividing a master contour image depicting a fullshape of a medicine by a dividing line as boundary, a master contourimage of a divided medicine obtained by dividing the medicine isregistered as a contour image of the contour of a divided medicine in acontour image database.

As per the present invention, it becomes possible to use a mastercontour image of a divided medicine for creating a master contour imagedatabase. Therefore, according to the present invention, a need toprepare separate images of a divided medicine for contour image databaseis eliminated.

In the medicine inspection device of the present invention, it ispreferable to include a rectangular guide for setting a divisional linecircumscribing a medicine area in the outside shape inspection image isassumed all over the medicine area, passing through the center of theguide for setting a divisional line and perpendicular to the length sideof the rectangle of the guide for setting a divisional line is specifiedas division candidate line, and a medicine region present on one sidewith the said division candidate line as boundary is defined as medicineregion CA, and a medicine region present on the other side is defined asmedicine region CB, and a non-overlapping region, formed by flipping themedicine region CA over the medicine region CB with the said divisioncandidate line as boundary, is defined as non-overlapping region CC, andthe division candidate line when the said non-overlapping region CC issmallest is specified as a dividing line.

According to this configuration, it becomes possible to specify adividing line at appropriate place for a medicine of any shape, andobtain a master contour image for the divided medicine. Moreover, theguide for setting the dividing line used in the present invention, forexample, can be a rectangle of minimum size that can completely surroundthe contour of the medicine.

In the medicine inspection device of the present invention, it isdesirable to include a side illumination on the side of the inspectionunit and away at a location higher than the inspection unit, wherein anoptical axis of the side illumination is directed towards the inspectionunit in a horizontal direction or upper than the horizontal direction.

According to this configuration, it becomes possible to obtain a vividimage of the medicine disposed in the inspection unit.

It is desirable that the medicine inspection device of the presentinvention has a configuration wherein medicines are supplied as acontinuous array of sachets formed by packaging one dose of the medicineper sachet in a packaging paper and aligning the sachets in form of astrip, and each sachet is able to be inspected one by one, the medicineinspection device further including an introduction unit for introducingthe continuous array of sachets, wherein the introduction unit includes:a horizontal portion wherein a continuous body of sachets is able to bedisposed in a horizontal state, a sachet detecting sensor capable ofdetecting a continuous body of sachets present on the horizontalportion, and an introduction failure determining means for determiningintroduction failure of a continuous body of sachets in the introductionpart, and wherein the sachet detecting sensor is provided in bothdirections with the direction of passage of the continuous body ofsachets in the horizontal portion as reference, and on condition thatthe continuous body of sachets is detected by one of the sachetdetecting sensors that are provided on both sides, the introductionfailure determining means is configured to judge that an introductionfailure of the continuous body of sachets has occurred.

According to this configuration, distortion of the continuous body ofsachets can be accurately detected, and inspection failures due tointroduction defects of a continuous body of sachets can be prevented.In addition, introduction of a continuous body of sachets in a distortedstate towards the inspection unit can be prevented, and such as damageof the continuous body of sachets can be prevented.

The medicine inspection device of the present invention may have aconfiguration wherein medicines are supplied as a continuous array ofsachets formed by packaging one dose of the medicine per sachet in apackaging paper and aligning the sachets in form of a strip, and eachsachet is able to be inspected one by one, and is able to show aninspection result, wherein a sachet of the continuous body of sachets isable to be classified based on dosing time, and among a plurality ofsachets corresponding to each doing time, a result of inspection fordesired sachet is able to be selectively displayed.

According to this configuration, in the results of inspection, itbecomes possible to selectively confirm only for the requested ones.With this, the operation of checking of result of inspection by a doctoror pharmacist can be all the more simplified.

A medicine packaging device of the present invention includes: themedicine inspection device of the present invention described above; amedicine feeding means capable of supplying a medicine according to aprescription; and a medication preparation means capable of gatheringthe medicine supplied from the medicine feeding means for each packageand dispensing the medicine; wherein a quantity of medicine dispensedfrom the medication preparation means is able to be inspected by themedicine inspection device.

In the medicine packaging device of the present invention, a medicineinspection device of the present invention described above is provided,and the quantity of medicine in each package supplied from a medicationpreparation means can be accurately checked.

According to the present invention, it becomes possible to provide amedicine inspection device capable of properly inspecting the quantityof solid medicines without inspection failures due to the solidmedicines being in a overlapped, contacting, upright state or the like,or due to the presence of packaging paper etc., and a medicinedispensing device equipped with such a medicine inspection device.

BRIEF DESCRIPTION OF THE DRAWINGS

The present disclosure is described in conjunction with the appendedfigures:

FIG. 1 is a perspective view showing the exterior configuration of amedicine inspection device according to one embodiment of the presentinvention.

FIG. 2 is a perspective view showing the main parts of the medicineinspection device according to one embodiment of the present invention.

FIG. 3 is a perspective view showing the main parts of the medicineinspection device according to one embodiment of the present invention.

FIG. 4 is a side view schematically showing the main parts of themedicine inspection device according to one embodiment of the presentinvention.

FIG. 5 is a plane view showing the main parts of the medicine inspectiondevice according to one embodiment of the present invention.

FIG. 6 is a plane view schematically showing the main parts of themedicine inspection device according to one embodiment of the presentinvention.

FIG. 7 is a plane view schematically showing a relationship between acontinuous body of sachets formed from a packaging paper and aninspection unit etc.

FIG. 8 is a block diagram showing the configuration of a control device.

FIG. 9 is an image showing an integrated interface.

FIG. 10 is an image showing individual interfaces.

FIG. 11 is an explanatory drawing schematically showing theconfiguration of a medicine packaging device according to one embodimentof the present invention.

FIG. 12 is a perspective view showing an example of providing anupright-state elimination means shown in FIG. 13( a).

FIGS. 13A and 13B are perspective views showing an example of anupright-state elimination means.

FIG. 14 is a perspective view of a medicine inspection device accordingto a modification example in a state wherein a front lid thereof isopen.

FIG. 15 is a perspective view showing the positional relationshipbetween the lighting device and diffusion light emitting device and thetransportation means used in the medicine inspection device shown inFIG. 14.

FIG. 16 is a perspective view showing an example of providing anupright-state elimination means shown in FIG. 13( b).

FIG. 17 is a front view showing one example of a continuous body ofsachets.

FIG. 18 is a block diagram showing a configuration of a positioningcontrol means.

FIG. 19 is a front view showing a medicine inspection device accordingto the second embodiment of the present invention.

FIG. 20 is a perspective view showing the internal structure of themedicine inspection device shown in FIG. 19.

FIG. 21 is a side view showing the main configuration of the medicineinspection device shown in FIG. 19.

FIG. 22 is a perspective view showing the configuration of theinspection unit and near rear/front means of the medicine inspectiondevice shown in FIG. 19.

FIG. 23 is a plane view showing the configuration near the inspectionunit of the medicine inspection device shown in FIG. 19.

FIGS. 24A and 24B are, respectively, a side view conceptually showing aconfiguration of the rear/front means and a plane view of meshmaterials.

FIG. 25 is a block diagram showing the configuration of the control unitemployed in the medicine inspection device shown in FIG. 19.

FIG. 26 is a flowchart describing the execution flow of the medicineinspection process performed in the medicine inspection device of FIG.19.

FIGS. 27A, 27B, 27C, 27D, 27E, 27F, 27G, and 27H are images showing theimages taken during the execution of medicine inspection process in themedicine inspection device of FIG. 19.

FIG. 28 is a flowchart describing the execution flow of the medicineinspection process performed in the medicine inspection device of FIG.19.

FIGS. 29A, 29B, and 29C are images respectively showing the displayexamples of the results of inspection by the medicine inspectionprocess.

FIGS. 30A and 30B are images respectively showing the display examplesindividually confirming the inspection result of the sachets.

FIGS. 31A and 31B are images respectively showing the display examplesindividually confirming the inspection results of the sachets.

FIGS. 32A and 32B are images respectively showing the display examplesindividually confirming the inspection results of the sachets.

FIG. 33 is an image showing one example of an image for positionrecognition used in a foreign object detection process.

FIG. 34 is a flowchart showing the execution flow of the foreign objectdetection process performed in the medicine inspection device of FIG.19.

FIGS. 35A, 35B, 35C, 35D, and 35E are images respectively showing theimages taken during the execution of foreign object detection process inthe medicine inspection device of FIG. 19.

FIGS. 36A, 36B, and 36C are, respectively, an image showing one exampleof operational image used when displaying a medicine master, an imageshowing a list of medicines having similar contour, and an image showingthe display example of master information about medicine.

FIGS. 37A, 37B, 37C, 37D, and 37E show a photographing jig.

FIGS. 38A and 38B are images showing a state wherein each face of amedicine is photographed using the photographing jig.

FIG. 39 is a flowchart describing the execution flow of the medicinemaster creation process performed in the medicine inspection device ofFIG. 19.

FIG. 40 is an explanatory drawing illustrating an example of acontinuous body of sachets with an empty sachet formed midway.

FIG. 41 is a flowchart showing the execution flow of the boundaryposition detection means performed in the medicine inspection device ofFIG. 19.

FIG. 42 is a perspective view of the appearance of an introduction unit.

FIG. 43 is a perspective view of the internal structure of theintroduction unit

FIG. 44 is a side view showing the appearance of an ejection unit.

FIG. 45 is a perspective view showing an ejection unit when viewed fromthe inside of the medicine inspection device.

FIG. 46 is a perspective view of the structure of an ejection unit.

FIG. 47 is a perspective view showing the major parts of a structureaccording to a modification example.

FIG. 48 is a perspective view showing the major parts of a structureaccording to a modification example.

FIG. 49 is a side view showing the major parts of a structure accordingto a modification example.

FIGS. 50A and 50B are, respectively, a perspective view and a side viewof an upright-state elimination means.

FIGS. 51A, 51B, and 51C are, respectively, a perspective view, a frontview, and a rear view of a conveyance guide according to a modificationexample.

FIG. 52 is a block diagram showing a structure of a control deviceaccording to a modification example.

FIGS. 53A and 53B are explanatory drawings to illustrate the method ofacquiring a divided tablet master image.

FIGS. 54A, 54B, 54C, and 54D are explanatory drawings to illustrate themethod of defining a dividing line used for acquiring a divided tabletmaster image.

FIGS. 55A and 55B are images showing one example of an operational imagethat is displayed when registering a divided tablet master contour imagein an inspection medicine database.

FIG. 56 is an image showing one example of an operational image that isdisplayed when registering a divided tablet master contour image in aninspection medicine database.

FIGS. 57A and 57B are images showing one example of an operational imagethat is displayed when registering a divided tablet master contour imagein an inspection medicine database.

FIGS. 58A and 58B are images showing one example of images shown to anoperator in each stage of operation.

FIG. 59 is an image showing one example of an image shown to an operatorin each stage of operation.

FIGS. 60A and 60B are illustrating one example of images shown to anoperator in each stage of operation.

FIGS. 61A and 61B are illustrating one example of images shown to anoperator in each stage of operation.

FIGS. 62A and 62B are illustrating one example of images shown to anoperator in each stage of operation.

FIG. 63 is an image showing one example of an image shown to an operatorin each stage of operation.

FIGS. 64A and 64B are illustrating one example of images shown to anoperator in each stage of operation.

FIGS. 65A, 65B, and 65C are illustrating one example of a journalshowing the result of inspection.

FIG. 66 is a flowchart showing the edge detection method with acomposite image in one embodiment of the present invention.

FIGS. 67A, 67B, 67C, 67D, 67E, 67F, 67G, and 67H are illustrating imagesacquired in each stage of a modification example of medicine inspectionprocess according to one embodiment of the present invention.

FIG. 68 is a flowchart showing a modification example of an edgedetection method with a composite image according to one embodiment ofthe present invention.

FIG. 69 is a flowchart showing a modification example of perforationdetection process according to one embodiment of the present invention.

FIG. 70 is a flowchart showing a modification example of medicine masterconstruction process according to one embodiment of the presentinvention.

FIGS. 71A and 71B are graphs schematically showing the brightnessdistribution of medicine and background image in a back lit singlechannel image acquired in the control flow in FIG. 70.

FIG. 72 is a flow chart showing a modification example of a method ofconstructing an inspection medicine database and a contour imagedatabase for a divided medicine according to one embodiment of thepresent invention.

FIG. 73 is a perspective view showing a modification example of anintroduction unit of a medicine inspection device according to oneembodiment of the present invention.

FIGS. 74A and 74B are illustrating, respectively, one example ofoperation condition setting screen displayed in the medicine inspectiondevice in one embodiment of the present invention and an image showingone example of a display method of the inspection result.

FIGS. 75A, 75B, 75C, and 75D show, respectively, a modification exampleof an upright-state elimination means in a plan view, a perspectiveview, a front view, and a side view.

FIGS. 76A, 76B, and 76C are respective images showing one example of animage displayed when executing a sampling inspection mode in themedicine inspection device according to one embodiment of the presentinvention.

FIGS. 77A and 77B are images respectively showing one example of amethod of displaying the results by visual inspection.

DETAILED DESCRIPTION OF THE INVENTION

Embodiments of the present invention will be described hereinafter withreference to the accompanying drawings, in which preferred exemplaryembodiments of the invention are shown. The ensuing description is notintended to limit the scope, applicability or configuration of thedisclosure. Rather, the ensuing description of the preferred exemplaryembodiments will provide those skilled in the art with an enablingdescription for implementing preferred exemplary embodiments of thedisclosure. It should be noted that this invention may be embodied indifferent forms without departing from the spirit and scope of theinvention as set forth in the appended claims.

First Embodiment

Next, a medicine inspection device 10 according to one embodiment of thepresent invention, and a medicine packaging device 100 provided withthis medicine inspection device 10 will be described in detail whilereferring to the diagrams. In the following description, the medicineinspection device 10, which is a characteristic part of this embodiment,will be described first, and subsequently the medicine packaging device100 will be described. Here, the example shown in this embodiment isjust one example of many embodiments that can be assumed with respect tothe present invention.

<<Medicine Inspection Device 10>>

The medicine inspection device 10 is a device for inspecting thequantity and type of a medicine to be inspected that is supplied in astate wherein each dose is packaged in a packaging paper. As shown inFIG. 1, the medicine inspection device 10 has an introduction unit 10 bprovided in the side surface of a casing 10 a for introducing a medicinefor inspection, and has an operation panel 10 c in the front. Medicineis packaged in a translucent packaging paper, and supplied to themedicine inspection device 10 in a state wherein it can be viewed fromoutside as shown in FIG. 7.

As shown in FIG. 7, medicine is supplied to the medicine inspectiondevice 10 in a state of a continuous body of sachets B wherein aplurality of sachets b, each containing one dose of medicine, arecontinuously formed. An information medium I associated withprescription information is attached to the beginning of the continuousbody of sachets B. As information medium I, conventionally well-knownidentification signs such as bar code, information recording media suchas IC ships, character information and symbols etc., about prescriptioninformation can be used. In the present embodiment, a continuous body ofsachets B is supplied with a bar code associated with prescriptioninformation at the beginning by printing or the like.

As shown in FIG. 2 through FIG. 6, the medicine inspection device 10 isprovided with a transportation means 12, inspection unit 14, vibrator16, shooting means 18, illuminating device 20, control device 22, andetc. Though not illustrated, a filter may be provided in the shootingmeans for distinguishing various types of information (name of patient,dose time, medicine type etc.) printed on a continuous body of sachets Bfrom the medicine of the continuous body of sachets B. Thetransportation means 12 is a meant to receive and convey a continuousbody of sachets B that is formed by packaging medicine. Thetransportation means 12 may be formed of conventionally well-known beltconveyor, roller conveyor etc. In this embodiment, a belt conveyor isemployed as a transportation means 12. When a continuous body of sachetsB formed of a packaging paper is detected by a supply detection means 24a provided in the upstream of the inspection unit in the conveyingdirection, the transportation means 12 operates under the control of acontrol device 22, which is described later, and conveys the continuousbody of sachets B sequentially in the downstream direction. When thedispense detection means 24 b, which is provided in the downstream end,confirms that the end of the continuous body of sachets B has beendispensed beyond the downstream of the inspection unit 14, the operationof the transportation means 12 stops.

The inspection unit 14 is provided approximately in the middle of aconveyance path formed by the transportation means 12. The inspectionunit 14 is the part where a medicine conveyed by the transportationmeans 12 will be positioned. That is, the inspection unit 14 is an areahaving approximately a size in which one sachet b formed of a packagingpaper can fit in. Therefore, by conveying a continuous body of sachets Bby the transportation means 12 such that a sachet b arrives on theinspection unit 14, a medicine to be inspected is positioned on theinspection unit 14 in a state packaged in a sachet b (packaging paper).

Here, the inspection unit 14 is divided into a plurality of areas(inspection areas 26) from the upstream side of a direction in whichmedicine (continuous body of sachets B) is conveyed by thetransportation means 12 towards the downstream side. In this embodiment,the inspection unit 14 has been divided into three inspection areas 26a, 26 b and 26 c from the upstream side toward the downstream side.

The vibrator 16 provides vibrations to the sachet b (medicine)positioned on the inspection unit 14. The vibrator 16 is capable ofcausing vibrations independently to each inspection area 26 a, 26 b, and26 c. The vibrator 16 that is employed in this embodiment is providedwith leaf springs 28 a, 28 b, and 28 c that function as a source forgenerating vibrations, and an shock imparting means 30 for impartingimpact to the leaf springs 28 a, 28 b, and 28 c.

Leaf springs 28 a, 28 b, and 28 c are provided for each respectiveinspection area 26 a, 26 b, and 26 c. The leaf springs 28 a, 28 b, and28 c are positioned directly below a sachet b (continuous body ofsachets B) that reaches the inspection unit 14, and can providevibrations to the sachet b and the medicine contained therein. The leafsprings 28 a, 28 b, and 28 c are provided orthogonally to the conveyingdirection of the continuous body of sachets B due to the transportationmeans 12. As shown in FIG. 6 and FIG. 7, the leaf springs 28 a, 28 b,and 28 c are supported in a cantilever state by fixing the fixing parts32 a, 32 b, and 32 c provided at one end. The fixing parts 32 a, 32 b,and 32 c are fixed on the side of device main body of the medicineinspection device 10 in positions away from the inspection unit 14(inspection areas 26 a, 26 b, and 26 c).

The shock imparting means 30 is provided directly below the other end(free end) of the leaf springs 28 a, 28 b, and 28 c. The shock impartingmeans 30 is comprised of motors 34 a, 34 b, and 34 c, and plectrums 38a, 38 b, and 38 c integrally mounted with respect to the rotating shafts36 a, 36 b, and 36 c of the motors 34 a, 34 b, and 34 c, and areprovided for each leaf spring 28 a, 28 b, and 28 c (inspection areas 26a, 26 b, and 26 c) respectively. Each motor 34 a, 34 b, and 34 c can beoperated independently. In addition, the plectrums 38 a, 38 b, and 38 care provided substantially perpendicular to the rotating shafts 36 a, 36b, and 36 c, and with the rotation of the rotating shafts 36 a, 36 b,and 36 c, an impact can be added through collision against the free endsof the leaf springs 28 a, 28 b, and 28 c. Therefore, the shock impartingmeans 30 can independently provide impact to each leaf spring 28 a, 28b, and 28 c (inspection areas 26 a, 26 b, and 26 c), generatingvibrations in the upper/lower directions.

The shooting means 18 is intended for photographing a medicine disposedon the inspection unit 14, and is disposed vertically above theinspection unit 14. A lighting device 20 is intended for irradiating theinspection unit 14 when photographing with the shooting means 18, and isdisposed vertically above the inspection unit 14 similarly to theshooting means 18.

The lighting device 20 includes a light emitting part 42 of annularshape. The light emitting part 42 emits light with a plurality of lightemitting diodes 44 as light source provided in the entire circumference.If an area (virtual area 40) equivalent to the area of the inspectionunit 14 is imagined in a vertical direction with respect to theinspection unit 14, the light emitting part 42 is provided so as tosurround this virtual area 40. The optical axis of each light emittingdiode 44 is directed towards the light emitting part 42. That is, theoptical axis of each light emitting diode 44 is directed in radiallyinward of the light-emitting unit 42 (a direction toward the inside fromthe outside of the virtual area 40) and in a downward direction. Withthis, as shown by arrows in FIG. 4, each medicine disposed on theinspection unit 14 in a state packaged by a packaging paper can beobliquely irradiated from above and prominently accentuate the contourof each medicine.

The control device 22 is provided for the operation of the medicineinspection device 10 and carrying out inspection, and consists of apersonal computer, a dedicated board with electronic components etc.,and the like. As shown in FIG. 8, the control device 22 includes anoperation control unit 50 for controlling the operations of variousparts of the medicine inspection device 10, and an informationprocessing unit 60 for performing information processing based oninformation obtained by the operation of the various parts, and carryingout inspection of medicine contained in each sachet b. An operationcontrol unit 50 controls the operation of transportation means 12,vibrator 16, imaging device 18, and lighting device 20 described above.

When a supply of a continuous body of sachets B formed from a packagingpaper is detected by the supply detection means 24 a that is provided inthe upstream of the inspection unit 14, the operation control unit 50operates the transportation means 12 and moves the continuous body ofsachets B to the inspection unit 14, and each time the inspectionoperation, which is described later, is completed, it will control themovement by sequentially moving the sachets in the downstream directionby an amount equivalent to one sachet b at a time. Further, afterstarting the operation of sequentially dispatching the continuous bodyof sachets B by the transportation means 12, the operation control unit50 makes sure that all sachets b containing the medicine to be inspectedhave passed through the inspection unit 14 based on the detection resultof the dispense detection means 24 b provided in the downstream of theinspection unit 14. Specifically, after a continuous body of sachets Bis detected by the dispense detection means 24 b, at the instant whenthe continuous body of sachets B is no longer detected by the dispensedetection means 24 b, the operation control unit 50 determines that theend section of the continuous body of sachets B has reached thedownstream of the inspection unit 14 and that all sachets b have passedthrough the inspection unit 14. When all sachets b have been confirmedto have passed through the inspection unit 14, the operation controlunit 50 stops the operation of the transportation means 12.

When a sachet b containing a medicine to be inspected reaches theinspection unit 14, the operation control unit 50 operates the imagingdevice 18, and the sachet b disposed in the inspection unit 14 and themedicine packaged therein can be photographed. During the course ofphotographing by the imaging device 18, the inspection unit 14 can beilluminated by operating the lighting device 20 by the operation controlunit 50. Also, based on the command from an information processing unit60, which is described in detail later, the control section 50 canoperate the vibrator 16, and generate vibrations in each inspection area26 a, 26 b, and 26 c of the inspection unit 14.

The information processing unit 60 includes a distribution detector 62,a vibration controller 64, a medicine information detector 66, aprescription information acquisition means 68 and a collation means 70.Based on the image photographed by the shooting means 18, thedistribution detector 62 detects the distribution condition of amedicine packaged in the sachet b that reached the inspection unit 14.The detection result of the distribution detector 62 is forwarded asdistribution condition detection information to a vibration needdetermination means 64. Moreover, the distribution detector 62 may becapable of carrying out a filtering treatment for distinguishing varioustypes of information (patient name, dosage time, medicine type etc.)printed on a continuous body of sachets B from the medicine of thecontinuous body of sachets B.

On the basis of distribution condition detection information receivedfrom the distribution detector 62, the vibration controller 64determines if there is a need for generating vibrations by the vibrator16, and based on this judgment result, can control the operation of thevibrator 16. Specifically, on the basis of the distribution informationdetection information, the vibration controller 64 determines if thereis an area where the medicine is unevenly distributed in each of theinspection areas 26 a, 26 b, and 26 c of the inspection unit 14. If themedicine is found to be unevenly distributed, the vibration controller64 determines that there is a need for operating the vibrator 16, and ifthe medicine is not found to be unevenly distributed, determines thatthere is no need for operating the vibrator 16.

If it is determined that there is a need to operate the vibrator 16, thevibration controller 64, on the basis of the uneven distributioncondition of the medicine, can determine in which area among theinspection areas 26 a, 26 b, and 26 c vibration needs to generated, andsend a command to the operation control unit 50 for operating thevibrator 16. To be more explicit, the vibration controller 64 sends acommand to the operation control unit 50 for controlling the operationof the shock imparting means 30 for vibrating the leaf spring, among theleaf springs 28 a to 28 c, that corresponds to an area having thelargest quantity of the medicine among the inspection areas 26 a, 26 b,and 26 c, and not to vibrate the leaf springs corresponding to otherareas. With this, the medicine distributed unevenly in any of theinspection areas 26 a, 26 b, 26 c will be moved to other areas, andpiling up or contact of medicines can be eliminated.

The medicine information detector 66, on the basis of an image taken bythe shooting means 18, identifies the type and quantity of a medicine.When the vibrator 16 is operated as described above, an image taken bymeans of the shooting means 18 operation is used for identification oftype of medicine and number by the medicine information detector 66.Also, if there is no need to operate the vibrator 16, an image taken bythe shooting means 18 at the instant a medicine (sachet b) forinspection reaches the inspection unit 14 is used for identification oftype of medicine and the number by the medicine information detector 66.

From an image obtained by the shooting means 18, the medicineinformation detector 66 can identify the types of medicines by a varietyof methods. For example, by identifying the shape of the outer edge of amedicine contained in an image obtained by the shooting means 18, thesize and shape of the medicine can be determined. Also, based on thecolor information of a region corresponding to a medicine in thephotographed image, the color of the medicine can be determined. Themedicine information detector 66, based on a database preparedbeforehand of the medicine properties such as medicine type, shape,size, color and etc., can identify the type of a medicine that is underinspection. The medicine information detector 66 can also identify thetype of a medicine and the like based on the information that is stampedor printed on the surface of a medicine.

The medicine information detector 66 can identify the quantity of amedicine by a variety of methods from an image obtained by the shootingmeans 18. For example, the quantity of a medicine can be found out byidentifying the outer edge of a medicine contained in an image obtainedby the shooting means 18 and counting the number of areas enclosed bythe outer edge. In addition, by such as checking how many things ofsimilar size and shape are present in a photographed image, it is alsopossible to find out the quantity for each type of medicine.

The prescription information acquisition means 68, on the basis ofprescription information, can acquire prescription information regardingthe type and the quantity of a medicine packaged in each sachet b. Inthis embodiment, a reading device 72 capable of reading the bar codeincluded at the head section of a continuous body of sachets B, which isa continuous body of sachets b, is provided in the upstream of thetransportation means 12 with respect to the inspection unit 14 in theconveying direction. The prescription information acquisition means 68is capable of accessing an external recording means (not illustrated) inwhich the prescription information is stored, and based on informationmedia I such as bar code, ID number and the like read by a readingdevice 72, the prescription information can be acquired from anexternally mounted recording device or the like.

The collation means 70 can compare the information relating to the typeand the quantity of a medicine detected by the medicine informationdetector 66 described above with the prescription data acquired from theprescription information acquisition means 68, and verify whether thetype and the quantity of a medicine contained in a sachet b is as perthe prescription information.

In addition to the configuration described above, the control device 22is provided with an inspection result output means 80 for outputting theinformation showing the results of inspection obtained from collation bythe collation means 70 to an output device such as a display 22 aprovided in the control device 22, and an inspection result adjustmentmeans 82 for correcting the results of inspection and the like. In themedicine inspection device 10 of this embodiment, the information thatis output from the inspection result output means 80 can be displayed onthe display 22 a as shown in FIG. 9 and FIG. 10.

A display screen (hereafter also referred to as ‘general interface’)shown in FIG. 9 shows a list of results of image inspection. In thegeneral interface, display fields displaying various types ofinformation such as prescription attribute information column 81,package identification information column 82, medicine list displaycolumn 83 etc., and buttons such as menu button 84, finish button 85,and batch change button 86 etc. are displayed.

In the prescription attribute information column 81, based on theprescription information acquired from a recording device (notillustrated) or the like provided in the medicine packaging unit 120 ofthe medicine packaging device 100, which is described later in detail,information such as the patient identification information such as apatient name, ID number and the like to whom the inspection medicine isprescribed, the number of packages, number of dosing days of theprescribed medicine and number of doses etc., is displayed. In thepackage identification information column 82, the position of thecurrently selected sachet b from the beginning is displayed.

The medicine list display column 83 is a column provided for displayingas thumbnails the images used for carrying out inspection of each sachetb constituting a continuous body of sachets B. In the medicine listdisplay column 83, according to the result of inspection, the thumbnailimages can be displayed in a different display format. Specifically, athumbnail image of a sachet b in which the medicine quantity and typecontained therein have been determined to match the prescriptioninformation (hereafter also referred to as ‘normal sachet b’), and athumbnail image of a sachet b in which either the quantity or the typeor both have been determined to be different from the prescriptioninformation (hereafter also referred to as ‘defective sachet b’), areenclosed by frames of different colors or lines.

The menu button 84 is a button intended for displaying a list ofoperational menus. The finish button 85 is a button intended forconfirming and finishing a series of inspection results. The batchchange button 86 is a button provided for collectively switching betweenan approval and disapproval of the inspection results of all sachets bdisplayed in thumbnails. In this embodiment, a touch panel system isused as display 22 a, and by touching with a finger the area wherevarious buttons 84, 85 and 86 described above are displayed, varioustypes of operations, which is described later in detail, can beperformed.

The display screen shown in FIG. 10 (hereafter also referred to as“individual interface”) is an interface displayed by selecting athumbnail image that is displayed in the medicine list display column 83in the general interface of FIG. 9. The individual interface displaysthe details of inspection results of a medicine packaged in a sachet bpertaining to the selected thumbnail image, and they can be suitablyedited, etc.

In the individual interface, display columns for displaying varioustypes of information such as a prescription attribute information column90, image information column 91, package identification informationcolumn 92, inspection details information column 93, general inspectioninformation column 94 and etc. are provided. In the inspection detailsinformation column 93 and general inspection information column 94,buttons 95 and 96 are displayed for correction, modification,confirmation and the like of respective inspection information. Further,in the individual interface, in addition to the buttons 95 and 96, menubutton 97, medicine package list button 98, and prescription finishbutton 99 etc., are displayed. In the individual interface, by touchingwith finger the region where various buttons 95, 96, 97, 98 and 99 aredisplayed, various types of operations, which are described later indetail, can be performed.

To describe various parts of the individual interface more specifically,in the prescription attribute information column 90, similarly to theprescription attribute information column 81 of the general interfacedescribed above, displays information such as the patient identificationinformation like name, ID number and etc. of the patient to whom theinspection medicine is prescribed, the number of packages, the number ofdosing days of the prescribed medicine and the number of doses etc. Inthe image information column 91, the image of the selected sachet b usedfor inspection of the medicine is displayed. In the packageidentification information column 92, the position of the currentlyselected sachet b from the beginning is displayed.

In the inspection details information column 93, the inspectioninformation (type and quantity of medicine) about a currently selectedsachet b acquired by the medicine information detector 66 is listedtogether with an image showing the shape of the medicine. Here, the nameand quantity of the medicine listed in the inspection detailsinformation column 93 is the official prescription information obtainedfrom a recording device provided externally or the like, and the resultof the inspection is shown in the form of buttons 95 provided for eachmedicine. Specifically, the result of verification by the collationmeans is displayed as ‘OK’ for a medicine judged to be correctlypackaged, and ‘NG’ for a medicine judged to be incorrectly packaged. Inaddition, a “Similar exist” is displayed for a medicine that cannot becorrectly determined by verification by the collation means 70.

In the inspection details information column 93, when the partdisplaying the name of the medicine or the part displaying image of themedicine shape is selected by touching, the region corresponding to themedicine selected is explicitly indicated in the image display column91. Specifically, by enclosing the region corresponding to the selectedmedicine with a line having a color different from others, or a colorthat is same as the color of button 95 that is provided for eachmedicine, etc., the medicine is displayed in a way that it isidentifiable from others.

It is possible to correct an inspection result by touching with fingeror the like and selecting the buttons 95 displayed in the inspectiondetails information column 93. Specifically, for a medicine for whichthe inspection result of ‘OK’ or ‘NG’ is displayed in button 95, if theoperator visually determines that the inspection result is incorrect,the inspection result can be modified by selecting a button 95 for thatmedicine. When the inspection result is changed from a state of ‘NG’,the display of the button 90 is switched to a display of ‘Visual OK’.

Similarly, when changing from the inspection result of ‘OK’, the displayof the button 95 is switched to a display of ‘Visual NG’. Similarly,when ‘Similar exists’ is displayed on button 95, an operator can switchto ‘Visual OK’ upon determining that it is a correct medicine based onvisual observation, and can also switch to ‘Visual NG’ upon determiningthe medicine is incorrect. Further, by selecting the button 96, it ispossible to batch convert the inspection results displayed on buttons 95in detailed information display column 93.

When associating the name of a medicine listed in inspection detailsinformation column 93 with the image of the medicine displayed in theimage information column 91, use a finger or the like to touch the areawhere the medicine is displayed in the image information column 91 andmove it to the section in the inspection details information column 93where the name of the medicine is displayed. That is, after using afinger or the like to touch the section in the image information column91 where the image of the medicine is displayed, by performing theso-called drag-and-drop operation, the name of the medicine and theimage of the medicine are associated. With regard to the medicine thatwas associated in this manner, the display of the button 95 is switchedto ‘Visual OK’.

As a result of the inspection by medicine information detector 66 andcollation means 70 described above, if there is anything that cannot beidentified is present in the image, there will be a mention to that inthe inspection details information column 93. Specifically, as shown inthe example shown in FIG. 10, the medicine name and the quantity areshown by symbols such as ‘?’ mark or characters etc.

In the inspection general information column 94, the quantity ofmedicine and identification result of the entire selected sachet b aredisplayed. Specifically, in the general inspection information means 94,a medicine quantity display part 94 a showing whether the quantity is asper the prescription information or not, and an identification resultdisplay part 94 b that displays the quantity of medicine wherein theresult of inspection displayed in button 95 is ‘OK’ or ‘Visual OK’. Inthe example shown in FIG. 10, due the presence of a medicine that is notidentifiable, it has been identified that 8 nos. of the medicine weredetected in contrast to the quantity of a medicine specified in theprescription information being 7, and therefore, a display as 8/7 isshown in the medicine quantity display part 94 a. Further, since 4medicines for which the result of inspection is ‘OK’ or ‘Visual OK’ arepresent while the quantity of medicine specified in the prescriptioninformation is 7, a display of 4/7 is shown in the identification resultdisplay part 94 b.

The menu button 97, similarly to the menu button 84 described above, isintended for displaying a list of operation menus. The medicine packagelist button 98 is intended for displaying the general interfacedescribed above. The prescription finish button 99 is a button forclosing the individual interface. When the prescription finish button 99is selected, the information of setting changes in the individualinterface is saved as inspection information.

<<Medicine Packaging Device 100>>

A medicine packaging device 100 is a device capable of dividing andpacking medicine as per the input prescription data and dispensing them.As shown in FIG. 11, the medicine packaging device 100 has a medicineinspection part 110 consisting of a medicine inspection device 10described above, and a medicine packaging part 120 for packaging themedicine. The inside of the body of the medicine packaging part 120 isprovided with a medicine supplier 130, a medication preparation means150, and a medicine packing means 180.

The medicine supplier 130 is provided for storing solid medicine,appropriately dispensing the solid medicine according to theprescription, and supplying to the medicine packing means 180. Themedicine supplier 130 includes a feeding part 132. The feeding part 132has the function of storing the solid medicine, and dispensing the solidmedicine as per prescription towards the medication preparation means150. The medication preparation means 150 has the function of storingthe solid medicine supplied from the feeding part 132 per package, andsequentially dispensing towards the medicine packing means 180.

The feeding part 132 has a feeder type feeding part 136 and a manualfeeding part 138 as a means for supplying solid medicine. Furthermore,the feeding part 132 is provided with a standby hopper 140, collectinghopper 142, and a manual feed hopper 144, etc. The feeder type feedingpart 136 is provided with a plurality of cassette type medicine feeders146, and a solid medication prepared in advance in each medicine feeder146 for each medicine type can be dispensed according to theprescription. A standby hopper 140 is disposed below a feeder typefeeding part 136. After collecting one package of the solid medicinedischarged from each medicine feeder 146, the standby hopper 140 will beable to dispense them at a time. The solid medicine dispensed from thestandby hopper 140 is supplied one package at a time to the medicinepreparation means 150 via a collection hopper 142 provided below thestandby hopper 140.

The manual feeding part 138 is provided separately from the feeder typefeeding part 136, and can supply solid medicine to the medicinepreparation means 150 similarly to the feeder type feeding part 136.

The medicine preparation means 150 is disposed in the downward directionof the feeding part 132 described above. The medicine preparation means150 can store one package worth of solid medication received from themedicine supplier 130 via a collection hopper 142 or manual feed hopper144, and supply them towards the medicine packaging means 180.

The medicine packaging means 180 can form each sachet b by folding astrip-shaped packaging paper prepared beforehand and heat sealing it orthe like, and also package in a sachet b one dose worth of medicine thatwas supplied from the medicine preparation means 150. As a result, astrip of continuous body of sachets B is formed from a continuum of alarge number of sachets b. The continuous body of sachets B formed bythe medicine packaging means 180 is discharged towards medicineinspection part 110 through an outlet 200 provided in the body of themedicine packaging part 120.

Here, a connecting part 210 that can connect to the outlet 200 of themedicine packaging part 120 is provided to the medicine inspectiondevice 10 constituting the medicine inspection part 110, and themedicine inspection part 110 and medicine packaging part 120 areconnected via this connecting part 210. Further, it is configured suchthat it is possible to introduce a continuous body of sachets Bdispensed from the outlet 200 into the medicine inspection part 110 viathe connecting part 210, and to feed it to the medicine inspectiondevice 10. Accordingly, in the medicine packaging device 100, when acontinuous body of sachets B is formed by the medicine packaging means180, then, the medicine contained in each sachet b of this continuousbody of sachets B can be continuously inspected.

As described above, in the medicine inspection device 10 of thisembodiment, based on the image obtained by photographing the medicinedisposed on the inspection unit 14 with the shooting means 18, thedistribution condition of the medicine in the inspection unit 14 isdetected by distribution detector 62, and vibrations are generated inthe area where a largest number of medicines exists among the inspectionareas 26 a to 26. Therefore, even if there is an overlap or contact ofmedicines, or the medicines are in a upright state in the sachet bsupplied from medicine packaging part 120 to medicine inspection device10, it is possible to disperse and separate the medicines by providingvibrations as well as to make them in a fallen state wherein printedcharacters or stamping are visible to detect the quantity and type of amedicine by medicine information detector 66. Therefore, even thoughmedicine is packaged by a packaging paper, the medicine inspectiondevice 10 is possible to accurately find out the quantity and type ofthe medicine.

In the medicine inspection device 10 of this embodiment, the vibrator 16generates vibration in an area among the inspection areas 26 a-26 c witha largest quantity of the disposed medicine, and vibration is notgenerated in the other inspection areas 26 a-26 c. With this, even if amedicine is sealed inside a sachet b in a state of overlap or contactwith other medicines, or sealed in an upright state, such medicines canbe smoothly and effectively separated and dispersed. Therefore, in themedicine inspection device 10, it is possible to accurately capture eachmedicine one by one. Further, by making medicines in a fallen state, itis possible to not only accurately capture the surface of the medicine,but also to accurately capture the characters or symbols printed on thesurface. Accordingly, in the medicine inspection device 10, the medicinetype can be identified very smoothly and accurately.

This embodiment uses a configuration wherein vibration is generated inan area among the inspection areas 26 a to 26 c where there is a largestconcentration of a medicine, and vibration is not generated in otherareas at all, but the present invention is not limited to this, and itis also possible such as to vary the magnitude of the vibrationgenerated in each inspection area 26 a to 26 c depending on the quantityof the medicine. Specifically, it is also possible to generate maximumvibration in an area among the inspection areas 26 a to 26 c having ahighest distribution of the medicine, minimal vibration in an areahaving a least medicine quantity, and to generate moderate vibration inan area having moderate distribution of the medicine. In other words, itmay be configured such that vibration is provided preferentially in anarea among the inspection areas 26 a to 26 c having more medicine thanan area with less quantity of medicine than this.

In the medicine inspection device 10, a need for generating vibration isdetermined based on the distribution condition of the medicine on theinspection unit 14 detected by the distribution detector 62, and if itis determined by the vibration controller 64 that there is a need forgenerating vibration, the vibration is generated by the vibrator 16, andthen, an image is taken by the shooting means 18 and inspection iscarried out based on the image. When it is determined by the vibrationcontroller 64 that there is no need for providing vibration, vibrationwill not be generated by the vibration means 16, and based on an imagephotographed by the shooting means 18, inspection will be carried outfor the quantity and type of the medicine contained in the sachet b.Thus, in the medicine inspection device 10, since the vibrator 16 isoperated only when there is a need for dispersing the medicine, andtherefore, it is possible to improve the accuracy of inspection of amedicine, and to minimize the slowing of inspection speed due to theoperation of the vibrator 16.

In the medicine inspection device 10 of this embodiment, the vibrator 16is able to generate vibrations by the elastic force of the leaf springs28 a to 28 c, and therefore, the device configuration is extremelysimple. Moreover, although an example of a configuration using leafsprings 28 a to 28 c as a source of vibration of the vibrator 16 wasillustrated in this embodiment, the present invention is not limited tothis, and they may be substituted by ultrasonic wave vibrator etc., forexample. In addition, the vibrator 16 is capable of providing vibrationsin a vertical direction by the leaf springs 28 a to 28 c, but thepresent invention is not limited to this, and it is also possible toimpart vibrations in a direction other than a vertical direction such asa horizontal direction, etc.

The vibrator 16 employed in this embodiment is configured such that,among the leaf springs 28 a to 28 c, a leaf spring of 28 a to 28 cprovided corresponding to an inspection area of 26 a to 26 c that isdeemed to be in a non-vibrating state is made to be in a non-vibratingstate by not imparting impact by the shock imparting means 30, but thepresent invention is not limited to this. Specifically, it is alsopossible to provide a push-down means or the like to push down the leafsprings 28 a to 28 c, and by pushing down the leaf spring, among theleaf springs 28 a to 28 c, that is in a non-vibrational state by thepush-down means or the like, they may be moved away from the packagingpaper (sachet b). With such a configuration, it becomes possible toreliably prevent vibration from being applied to the medicine in theregion that should be non-vibrational among the inspection areas 26 a to26 c, and to disperse the medicine even more accurately, and as aresult, the inspection accuracy can be further improved.

In the medicine inspection device 10, the fixing parts 32 a to 32 cprovided at one end of the leaf springs 28 a to 28 c are fixed at alocation away from the inspection areas 26 a to 26 c. Due to this, theleaf springs 28 a to 28 c can generate substantially uniform vibrationsin any position of the inspection areas 26 a to 26 c, and the medicinecan be smoothly and reliably dispersed on the inspection unit 14.

In the medicine inspection device 10, the leaf springs 28 a, 28 b, 28 care disposed directly below the sachets b (continuous body of sachets B)that arrive in the inspection unit 14, and they are in direct contactwith the sachet b, and vibration can be provided to the sachet b and amedicine packaged therein. Also, vibration generated by the leaf springs28 a to 28 c is a decreasing vibration which will freely and graduallydecrease after applying an impact by the shock imparting means 30. Thisvibration is a vibration suited for dispersing medicine unlike aconstantly same vibration generated by conventionally known vibrationproviding mechanism such as ultrasonic vibrators or vibrators.Therefore, in the medicine inspection device 10, even when a medicine isfed in a state where the medicine is unevenly distributed in part of theinspection areas 26 a to 26 c, due to the dispersion effect by thevibration of the leaf springs 28 a to 28 c, it can be smoothly dispersedin the entire inspection unit 14 in a substantially uniform manner.

Further, in the medicine inspection device 10, the number of impactsapplied to the leaf springs 28 a to 28 c by the shock imparting means 30may be one or multiple. Although the medicine inspection device 10showed an example of applying impact intermittently by plectrums 38 a to38 c, which are attached to the rotating shafts 36 a to 36 c, byoperating the motors 32 a to 32 c as explained above, the presentinvention is not limited to this, and it is also possible to apply theimpact continuously.

In the medicine inspection device 10 of this embodiment, an annularlighting device 20 is provided in a position vertically away from theinspection areas 26 a to 26 c so as to surround an assumed virtual area40. The optical axis of light-emitting diodes 44 provided in the lightemitting part 42 of the lighting device 20 is directed towards theinspection areas 26 a to 26 c that are existing below in an obliquedirection. Accordingly, it is possible to illuminate a medicine disposedon the inspection unit 14 from outside and to photograph the medicine bythe shooting means 18, and to take an image to distinctly capture thecontour of the medicine. Therefore, in the medicine inspection device10, the contour or color of a medicine can be easily and accuratelycaptured when the image obtained from the shooting means 18 is processedby a medicine information detector 66, and therefore inspection failuresare minimized.

In this embodiment, a lighting device 20 is positioned vertically awayfrom the inspection areas 26 a to 26 c, that is, installed at a positionaway in the same direction from the shooting means 18, but the distancebetween the inspection areas 26 a to 26 c and the lighting device 20 ispreferably as short as possible. It is also possible to position thelighting device 20 on the sides of inspection areas 26 a to 26 c. It isalso possible to position the lighting device 20 below the inspectionareas 26 a to 26 c, that is, at a position in the opposite directionfrom the shooting means 18. Even when varying the position of thelighting device 20 in this manner, it is desirable to position thelighting device 20 such that the inspection areas 26 a to 26 c can beirradiated from outside towards inside in order to acquire an imagewherein the contour of a medicine is prominent.

Although this embodiment showed a case of disposing an annular lightingdevice 20 above the inspection unit 14 to accurately capture the contouror color of a medicine disposed in the inspection unit 14, the presentinvention is not limited to this, and it is also possible to installabove the inspection unit 14 a lighting device capable of generatingdiffused light such as a diffusion light emitting device 160 shown inFIG. 14 and FIG. 15 in addition to the lighting device 20, or byreplacing the lighting device 20 with such an illumination device, forexample.

Specifically, in the examples shown in FIG. 14 and FIG. 15, thediffusion light emitting device 160 is installed in addition to thelighting device 20. The diffusion light emitting device 160 has ahemispherical (so-called dome shape) exterior shape, and diffused lightcan be generated light in a circular light emitting surface 162 formedin the shape of a circular plane. The diffusion light emitting device160 is mounted on an annular illumination device 20 such that the lightemitting surface 162 is facing in the downward direction. The lightemitting surface 162 is roughly parallel to the inspection unit 14, andit is possible to emit the diffused light toward the inspection unit 14through the virtual area 40 enclosed by the lighting device 20.

By installing the diffusion light emitting device 160 as describedabove, a medicine disposed on the inspection unit 14 can be illuminatedwithout any occurrence of shadows, and the contour of the medicine, themarking stamped on the surface or the printed characters etc., can beclearly captured. With this, the detection accuracy of the quantity ortype of a medicine can be further improved.

Also, in the example shown in FIG. 14 and FIG. 15, although a diffusionlight emitting device 160 is mounted on a lighting device 20, it is notnecessary to mount it on the lighting device 20, and it may bepositioned away from the lighting device 20. Moreover, the diffusionlight emitting device 160 can be vertically movable or of anattachable/removable type as required.

In the medicine inspection device 10 of this embodiment, based on theprescription data, the prescription information acquisition means 68acquires prescription information of the medicine to be inspected, andthe collation means 70 collates this prescription information with thedetection information acquired by the medicine information detector 66.Therefore, according to the medicine inspection device 10, it ispossible to not only check the type and the quantity of medicines packedin a sachet b, but also to check whether a medicine packaged in a sachetb matches with the prescription data, and thus excels in usability.Moreover, although a configuration of collating prescription data anddetection data by providing a collation means 70 was illustrated in thisembodiment, the present invention is not limited to this, and aconfiguration without the collation means 70 is also possible. That is,the medicine inspection device 10 can be a device for just detecting thetype and quantity of a medicine for the sake of inspection.

Also, in the medicine packaging device 100 of this embodiment, aconnecting part 210 for connecting with the outlet 200 of the medicinepackaging part 120 is provided on the medicine inspection device 10 sideof the medicine inspection part 110. With this, by connecting themedicine inspection part 110 and medicine packaging part 120 through theconnecting part 210 and operating both of them in cooperationintegrally, the operation starting from packaging of the medicine tillinspection can be conducted as a chain of tasks.

Although this embodiment illustrated a configuration incorporating themedicine inspection device 10 as a medicine inspection part 110 of themedicine packaging device 100, the present invention is not limited tothis, and the medicine inspection device 10 may also be independentlyused. Further, although a configuration was illustrated wherein amedicine inspection part 110 including a medicine inspection device 10was integrated with a medicine packaging part 120 by providing aconnecting part 210, it is also possible to use the medicine packagingdevice 100 without integrating the medicine inspection part 110 andmedicine packaging part 120. Even in this case, by enabling the medicineinspection part 110 and medicine packaging part 120 to operate incooperation, the efficiency of a chain of operations starting frompackaging of the medicine till inspection can be improved.

Although an example of inspecting a medicine packaged in a packagingpaper was illustrated in this embodiment, the present invention is notlimited to this, and it is also possible to dispose a medicine on theinspection unit 14 prior to packaging by a packaging paper and to carryout the inspection.

Although an example of inspecting both quantity and type of a medicinedisposed on the inspection unit 14 was illustrated in this embodiment,the present invention is not limited to this, and it is also possible toinspect only the quantity or the type of a medicine.

Further, in the medicine inspection device 10, the sachet b formed bypackaging medicines is supplied continuously as a continuous body ofsachets B, and is disposed sequentially on the inspection unit 14.Therefore, in order to further improve the inspection accuracy, it isdesirable to contemplate some measures to improve the positioningaccuracy when conveying the continuous body of sachets B so that thecenter of each sachet b arrives at the center of the inspection unit 14.Specifically, for example, by having heat seal sections, or perforationformed between the adjacent sachets b in the continuous body of sachetsB as a mark, and by using this mark as reference, it is possible toimprove the positioning accuracy of a sachet b in the inspection unit14. Also, if the length of a sachet b is known beforehand, it may beconfigured such that, after a section to be referenced such as the headsection of a continuous body of sachets B is detected by a supplydetection means 24 a, the continuous body of sachets B is fedsequentially only by an extent equal to the length of the sachet b at atime, for example.

In the medicine inspection device 10 of this embodiment, the standing,overlap, contact and the like of medicines is eliminated by applyingvibrations with leaf springs 28 a to 28 c to the sachets b that arrivedat the inspection areas 26 a to 26 c, but it is also possible eliminatestanding or the like of medicines by further providing separatevibrations.

Specifically, the medicine inspection device 10 illustrates an exampleof moving a continuous body of sachets B of packaged medicine by thetransportation means 12 only at a certain direction towards theinspection unit 14, but instead of this, on the way from the upstream oftransportation direction to the inspection unit 14, it is also possibleto impart vibration (oscillation) to the medicine in the horizontaldirection by reciprocating the continuous body of sachets B in smallmotions in the horizontal direction. In other words, by oscillating acontinuous body of sachets B by alternately dispatching and retractingit, vibration in the horizontal direction may be imparted to themedicines inside each sachet b. By this, a medicine sealed inside asachet b in an upright state will assume a fallen state by the time itreaches the inspection unit 14. Further, it also becomes possible toreliably part and separate medicines that are overlapped with or incontact with other medicines.

Furthermore, by oscillating a continuous body of sachets B (sachet b) inthe horizontal direction on the way from the upstream of transportationdirection to the inspection unit 14 as described above, it becomespossible to make the medicines in a fallen and dispersed state beforethey reach the inspection unit 14. Therefore, a possibility that thevibration needs to be applied by the leaf springs 28 a to 28 c in theinspection unit 14 can be reduced. With this, it becomes possible tofurther reduce the time required for the inspection operation.

In the modified example mentioned above, although an example wasillustrated, wherein an overlap, contact or upright state of medicinesis eliminated by vibrating a continuous body of sachets B (sachet b) ina horizontal direction in addition to imparting vibration in theinspection unit 14, it is also possible to combine other means withvibrating a continuous body of sachets B (sachet b) in the horizontaldirection, or other means instead of vibrating the continuous body ofsachets B (sachet b) in horizontal direction for solving the problem ofoverlap, contact, or upright state of the medicines. Specifically, asshown in FIG. 12, in the conveyance path of the packaging paper in whichthe medicine is packaged, an upright-state elimination means 110, whichoperates so as to follow the surface of the packaging paper, may also beprovided in a place that is upstream of the inspection unit 14 in theconveyance direction.

To explain more explicitly, as shown in FIG. 12 and FIG. 13, theupright-state elimination means 110 is comprised of a spindle 112provided so as to across the conveyance path of the packaging paper, andarms 114 mounted so as to freely rotate with respect to the spindle 112.A plurality of arms 114 are provided along the axial direction of thespindle 112, that is, in the width direction of the conveyance path. Aroller 114 a is attached to the tip of an arm 114. Also, the arms 114are biased towards the conveyance path by springs 114 b. By this, withrespect to the surface of the packaging paper traveling through theconveying path, a roller 114 a can contact the packaging paper withappropriate strength that does not to damage the packaging paper or themedicine. Therefore, when the packaging paper travels through theconveyance path, the rollers 114 a roll along the surface of thepackaging paper, and the arms 114 rotate around the spindle 112 so as tofollow the surface of the packaging paper. Moreover, the material of therollers 114 a can be resin, metal, or etc. like the arms 114, or mayalso be an elastic body like sponge, rubber etc., or a soft material. Ifthe rollers 114 a are formed of a resin or metal, it is less likely tohave deformation or wear-out even on prolonged use, and a stableperformance can be maintained. Further, if an elastic material such assponge or rubber etc. or a soft material is used for the rollers 114 a,the shock applied to medicines can be suppressed to a minimum level, andbreakage or damage of the medicine can be prevented.

When an upright-state elimination means 110 as described above isprovided, during the period the packaging paper is conveyed towards theinspection unit 14, the rollers 114 a contact the packaged medicinethrough the packaging paper. With this, medicines packaged in thepackaging paper are pushed down, and an overlap or contact of themedicines is eliminated. Further, a medicine contained in an uprightstate is pushed down by contacting the arms 114 (rollers 114 a) throughthe packaging paper.

When an upright-state elimination means 110 described above is provided,it becomes possible to disperse the medicine before the sachet b forinspection reaches the inspection unit 14, and also overturn a medicinethat was packaged in an upright state. Thus, the frequency of occasionsin which medicines need to be dispersed by imparting vibration at theinspection unit 14 can be minimized. With this, it is possible tofurther decrease the time required for the inspection operation.

In the upright-state elimination means 110 described above, the rollers114 a may be provided in an area that is a part of the width directionof the conveyance path formed by the transportation means 12 as shown inFIG. 12, or the rollers 114 a may be provided over the entire width ofthe conveyance path as shown in FIG. 13B by using rollers 114 a that arewider than the ones shown in FIG. 13A. When such a configuration isused, since the entire surface region of each sachet b is traced byrollers 114 a, it becomes possible to more reliably overturn a medicinethat was packaged in an upright state in sachet b. With this, byanalyzing using an image taken by the shooting means 18, the type andquantity of a medicine can be identified with certainty, and theinspection accuracy can be further improved.

As explained above, reciprocating a continuous body of sachets B (sachetb) in small motions in the horizontal direction to oscillate thecontinuous body of sachets B in the horizontal direction and overturninga medicine packaged in an upright state by providing an upright-stateelimination means 110 are both effective measures for improving themedicine inspection accuracy and improving the inspection speed byreducing the frequency of vibration generation in the inspection unit14. In the medicine inspection device 10, though it is possible to adoptthese measures individually, it is preferable to use both measures intandem. By coupling the oscillation of a continuous body of sachets Bwith the upright-state elimination means 110, it is possible to achievefurther improvements in the inspection accuracy and inspection speed bycombining the effects of both.

In the medicine inspection device 10, a continuous body of sachets B issupplied in the form of being linked to each other as a strip, andtherefore, the medicine inspection operation can be continuously carriedout and the speed of inspection operation can be improved. On thecontrary, the packaging paper forming the sachet b is formed of a paperor a thin film etc., and it is assumed that the packaging paper is proneto damage even without applying a force that is not so large. Also, manyof the continuous body of sachets B are provided with perforations inthe boundary region of each sachet b so that a patient or the like caneasily cut off each sachet b. Therefore, there is a possibility that,when introducing a continuous body of sachets B from the introductionunit 10 b, the action of a tension exceeding the strength of thecontinuous body of sachets B may occur due to the influence of the forcetrying to pull the continuous body of sachets B into the device and aforce acting to the outside of the inspection device due to thecontinuous body of sachets B hanging or the like, and the continuousbody of sachets is damaged or broken. Therefore, in the medicineinspection device 10, it is desirable to provide a protection mechanismor the like of the continuous body of sachets B so that damage etc. ofthe continuous body of sachets B will not occur when introducing thesachets into the device.

Specifically, it is desirable to provide a protection mechanismcomprising an introduction unit oscillating member 220 in theintroduction unit 10 b of the medicine inspection device 10 as shown inFIG. 14, for example. The introduction unit oscillating member 220 isprovided with an introduction unit oscillating arm 224 and a roller 226.The introduction unit oscillating arm 224 is installed such that it canoscillate in a vertical direction as shown by the arrow in the diagram,and is biased towards the upper direction by a spring or the like, whichis not illustrated. The roller 226 is fixed such that it can rotatefreely with respect to the introduction unit oscillating arm 224.

A continuous body of sachets B supplied to the medicine inspectiondevice 10 travels over the roller 226 of the introduction unitoscillating member 222, and is introduced into the medicine inspectiondevice 10. When there is an action of forces such as a pulling forceacting when a continuous body of sachets B is conveyed towards theinspection unit 14, and a force acting when a continuous body of sachetsB is dangling, etc., the introduction unit oscillating arm 224 that isnormally biased upwards will oscillate in the lower direction, and thisprevents an excessively large force from acting on a continuous body ofsachets B. With this, a damage or breakage of a continuous body ofsachets B can be prevented. On the other hand, if there is an excess ina tension of the continuous body of sachets B itself, the roller of theintroduction unit oscillating member 222 naturally rises due to anupward bias of spring etc., and because the continuous body of sachets Bwill also be hauled up with this, it becomes possible to impartbeforehand the excess tension to this part.

In the medicine inspection device 10 shown in this embodiment, in orderto properly inspect the medicines that have been packaged one dose eachin sachet b, it is necessary to dispose a sachet b in a suitableposition on the inspection unit 14. That is, if the position of thesachet b containing a medicine for inspection deviates from theinspection unit 14, the medicine in sachet b to be inspected may come ina position away from the inspection unit 14, and accurate inspection maynot be possible.

When sequentially supplying sachets b in the form of a continuous bodyof sachets B, even if the deviation between the sachets b and inspectionunit 14 is very small in the initial stages, there is a possibility thatthe deviation may accumulate in the inspection of several sachets b, andbefore long the positional deviation between the inspection unit 14 andsachets b may become large enough to lead to inspection failure.Therefore, it is desirable that positioning of each sachet b on theinspection unit 14 is possible with high positioning accuracy, andespecially, when medicine to be inspected is packaged and supplied inthe form of a continuous body of sachets B, it is necessary to positiona sachet b on the inspection unit 14 with a high positioning accuracy.

Here, most of the continuous bodies of sachets B to be supplied to themedicine inspection device 10 are forming sachets b by folding astrip-shaped packaging paper into two substantially in the middle in thewidth direction and by sealing with longitudinal sealing parts s1extending in the width direction of continuous body of sachets B, and alateral sealing part s2 extending in the length direction of thecontinuous body of sachets. Further, between two sachets b and b thatare continuous in the length direction of the continuous body of sachetsB, the longitudinal sealing parts s1 and s1 are formed with a slight gaptherebetween, and a boundary d of perforation or the like is formedbetween the sachets. Therefore, if it is possible to properly identifythe position of the boundary d, then the position of sachet b(continuous body of sachets B) can be fine-tuned based on this resultand the positioning accuracy between the sachets b and the inspectionunit 14 can be improved.

However, it is not likely that the perforations or the like forming theboundary d can be accurately identified by imaging etc. Also, if theimage resolution is enhanced to the point that the boundary d can beidentified, it is likely that the processing speed will decline becauseof image processing speed etc. Therefore, if directly deriving theposition of boundary d is difficult or if it is likely that theprocessing speed or the like will decrease because of the directderivation etc., the positional information of the boundary d can bedetermined based on the positional information of the longitudinalsealing part s1 such as the positioning control means 230 shown below.

Specifically, the positioning control device 230 shown in FIG. 18includes a position detection shooting means 232 for taking an image oflongitudinal sealing parts s1, and a longitudinal seal positiondetecting means 234 to derive the position of the longitudinal sealingpart s1 by analyzing the image obtained by the position detectionshooting means 232. Also, the positioning control means 230 is providedwith a boundary position detection means 236 for deriving the positionof the boundary d based on the position of the vertical seals s1 derivedby the longitudinal seal position detecting means 234, and a positionadjusting means 238 for fine tuning the position of the continuous bodyof sachets B by operating the transportation means 12 based on thedetection result of the boundary d.

With regard to two sachets b and b that are continuous in thelongitudinal direction of a continuous body of sachets B, the positiondetection shooting means 232 is capable of setting a vertical sealposition detection region that includes at least a part of the twolongitudinal sealing parts s1 and s1 positioned next to each other withthe boundary d therebetween, and taking an image of that region.Specifically, the x coordinate of the seal marks (for example, marks ofknurling points of the welding rollers (not illustrated)) formed in thelongitudinal sealing parts s1 and s1 in the said region and its totalnumber can be determined from the image, and by adding all thecoordinates and dividing by the total number, the boundary position canbe derived. Or, by measuring the leftmost and rightmost x coordinates ofthe seal marks of the said longitudinal sealing position detectionregion and deriving its intermediate value, the coordinates of theposition of the boundary d can be derived. The position adjusting means238 compares the position of the boundary d derived from the boundaryposition detection means 236 and the position where the boundary dshould be positioned, and operates the transportation means 12 so thatthe boundary d comes to the normal position.

By providing a positioning control device 230 as described above, evenif the boundary d of the sachets b and b is perforations or the like,which is difficult to accurately identify by just taking a photograph ofit, it is possible to accurately determine the position of the boundaryd of a sachet b, and based on this result, the sachet b to be inspectedcan be accurately positioned with respect to the inspection unit 14.With this, the inspection accuracy and inspection speed of the medicineinspection device 10 can be further improved.

In the above-mentioned medicine inspection device 10, it is desirable toprevent the transportation errors of the continuous body of sachets B inorder to accurately position a sachet b with respect to the inspectionunit 14. Here, in order to improve the reliability of transportation ofthe continuous body of sachets B, it is preferable to provide a pushingmechanism for pushing the continuous body of sachets B onto theconveyance surface of the transportation means 12. Therefore, as shownin FIG. 12, in the medicine inspection device 10, it is desirable toprovide one or a plurality of pushing rollers 240 in the middle of theconveyance path formed by the transportation means 12 to push thecontinuous body of sachets B on the conveyance surface with the help ofthese pushing rollers 240.

Second Embodiment

Next, a medicine inspection device 300 according to the secondembodiment of the present invention will be explained in detail whilereferring to diagrams. Moreover, in the medicine inspection device 300of this embodiment, the same referential numbers are used for the partsthat are common to the medicine inspection device 10 described above,and their detailed description may be omitted.

As shown in FIG. 19, the medicine inspection device 300 hasapproximately the same exterior as the above-mentioned medicineinspection device 10. As shown in FIG. 20, the medicine inspectiondevice 300 is provided with the medicine inspection device 10 describedabove, a similar transportation means 12, and a shooting means 18 in thecasing 302. Further, the medicine inspection device 300 is provided witha diffusion light emitting device 160 used in the modified example shownin FIG. 14. On the other hand, the configuration of the medicineinspection device 300 differs from the medicine inspection device 10 inthat the vibrator 16 and the annular lighting device 20 are excluded.The configuration of the medicine inspection device 300 also differsfrom that of the medicine inspection device 10 in that an inspectionunit 310 instead of inspection unit 14, a control device 330 instead ofcontrol device 22 (see FIG. 25), and an introduction unit 304 instead ofintroduction unit 10 b are provided. The medicine inspection device 300is described below with a focus on the characteristic configuration.

The introduction unit 304 is provided on the side surface of the casing302 for introducing medicines for inspection. The introduction unit 304has guide pieces 306 provided on both sides in order to guide a sachet bor a continuous body of sachets B so that it does not incline whensupplied to the inside of the casing 302. Moreover, the end section of aplate that constitutes the bottom surface 308 of the introduction unit304 is downwardly-bent in an arc shape so that a continuous body ofsachets B does not get caught when the continuous body of sachets B issupplied.

The inspection unit 310, similar to the inspection unit 14 of the firstembodiment described above, is a section where medicine for inspectionpackaged in a sachet b is disposed. As shown in FIG. 20 and FIG. 21, theinspection unit 310 is disposed directly below the shooting means 18 andthe diffusion light emitting device 160 in the same way as theinspection unit 14. As shown in FIG. 20 through FIG. 23, the inspectionunit 310 is provided with an imaging stage 312 for disposing a sachet b,and a backlight 314 to irradiate a sachet b disposed on the imagingstage 312 from the back side.

The imaging stage 312 is fabricated from a transparent plate, and has asize that is large enough for one sachet b to be mounted thereon. Thebacklight 314 is provided on the rear side (lower direction in thediagram) of the imaging stage 312, that is, in a region opposite to theshooting means 18 through the imaging stage 312. The backlight 314 isintended for illuminating substantially the entire area of the imagingstage 312, and can illuminate the whole sachet b mounted on the imagingstage 312 from the back side.

The backlight 314 can emit light in a dot shape at each predeterminedpitch to substantially the entire illumination region of the imagingstage 312. Specifically, as shown in FIG. 24, the backlight 314 isprovided with a light source part 316 housed inside a casing 314 a, anda mesh member 318 provided on the top surface of the casing 314 a. Thecasing 314 a is configured from a box with its top open. The lightsource part 316 is provided with light emitting diodes as light source.Further, the light source part 316 is designed to generate a light of awavelength same as or longer than red. In this embodiment, lightemitting diodes capable of generating red color light is used as thelight source of the light source part 316. Further, the optical axis ofthe light emitting diodes provided in the light source part 316 isdirected in substantially the perpendicular direction of the imagingstage 312.

A dot forming part 318 is provided between the light source part 316 andthe imaging stage 312 on which a sachet b is to be disposed. As shown inFIG. 24( b), the dot forming part 318 is configured from a mesh havinggrids (openings) of predetermined pitch. Accordingly, when the lightsource part 316 emits light, the light will pass through the dot formingpart 318, and light in a dot pattern is emitted onto the imaging stage312.

The control device 330 used in this embodiment is implemented on acomputer by installing a software to the computer. The control device330 has a configuration shown in FIG. 25, and is capable of executing amedicine inspection process to check whether medicine packaged in eachsachet b is as per prescription, and a foreign object detection processto find out whether there is a foreign object other than the medicine ineach sachet b.

<<Medicine Inspection Process>>

As shown in FIG. 25, the control device 330, as an inspection processexecution means for executing the medicine inspection process, includesa medicine information detector 340 and a prescription informationacquisition means 342, and verification means 344. The medicineinformation detector 340 performs identification of medicine type aswell as counting of medicine based on an image photographed by theshooting means 18. As shown in FIG. 26, the medicine informationdetector 340 can detect the information (type, quantity) about themedicine by sequentially executing an image processing that is roughlycategorized into three steps that are a basic image acquisition process,inspection area defining process, and image inspection process.

Specifically, the medicine information detector 340 acquires an image(hereafter also referred to as ‘back lit image’) obtained by theshooting means 18 by illuminating a sachet, which is disposed on theimaging stage 312, from the back side (the lower side in the diagram) bythe above-mentioned backlight 314 in the basic image acquisition processof step 1-1, as the basic image for medicine inspection. With this, abasic image shown in FIG. 27A is obtained.

Here, when printing or the like is not provided on the sachet b,substantially the whole section imaged in black color or dark color inthe basic image (back lit image) is assumed to be due to objects such asmedicine etc. However, if printing is provided on the sachet b, theprinted area is also imaged in a black color or a dark color similarlyto objects such as a medicine etc. Therefore, it is likely that asection that is imaged in black color or a dark color in the basic imagedescribed above includes an area in which printing is provided (printarea). Accordingly, in order to accurately determine the medicine typeor quantity by an image inspection, it is necessary to identify andexclude a print area from a region imaged in the black color or a darkcolor in the basic image obtained in the basic image acquisitionprocess.

In the inspection area defining process executed in step 1-2, the regionwherein an object such as medicine exists is extracted by removing theprint area from the said basic image, and with this extracted region asa reference, a process for defining an appropriate area for imageinspection is executed. Specifically, in the inspection area definingprocess, a process comprised of three processes that are an objectexistence area derivation process, an expansion process and a regiondefining process is executed by the medicine information detector 340.The inspection area defining process is executed as per the flowchartshown in FIG. 28.

First, in the step 2-1, an object existence area derivation process isexecuted. The object existence area derivation process is a process forextracting a region wherein objects such as medicine are thought toexist (hereafter also referred to as ‘object existence area’) from thebasic image. The object existence area derivation process is executed byderiving dot shaped translucent region due to emission of light by thebacklight 314 and the print area due to printing provided on the sachetb as the regions to be excluded, and deleting those from the image areaof the basic image.

That is, in step 2-1 a, an edge detecting process, which is a processfor detecting edges included in the basic image, is executed.Specifically, in step 2-1 a, by processing with an edge extractionfilter such as the conventionally well-known Sobel filter, an edgeincluded in the basic image is extracted (see FIG. 27B). Then, in step2-1 b, the region enclosed by the edge extracted in step 2-1 a(hereafter also referred to as ‘edge surrounding region’) is selected,and an image processing of enlarging the edge surrounding region isperformed. The expansion width of the edge surrounding region can besuitably determined based on the results of previous experiments, or byderiving based on a predetermined formula etc.

Here, regarding the section of the sachet b with printing, the dotshaped light from the backlight 314 passes through the packaging paperand is photographed. In other words, although substantially the entirearea of the print area is black color or dark color in the basic image,a section through which dot shaped light is transmitted is hollow. Onthe other hand, regarding a section wherein an object such as medicineexists, the light emitted from backlight 314 does not pass through, andit is photographed in totally black or dark color in the basic image.

Regarding the expansion width of the edge surrounding region in step 2-1b, considering the relevant characteristics, it is desirable that theexpansion width be set such that the edge surrounding regionscorresponding to adjacent dot-shaped translucent regions are connectedby expansion of the edge surrounding region. Further, regarding theexpansion width of the edge surrounding region, it is desirable to setto the degree of expansion width so as to paint out a region inside theoutline forming the outer edge of the print area by expanding the edgesurrounding regions corresponding to dot-shaped translucent regionsformed by transmission through the print area. In this embodiment, theexpansion width of an edge surrounding region is set so as to complywith these conditions. When the image processing of expanding an edgesurrounding region is finished as described above, as shown in FIG. 27C,the print area present in the basic image will assume a state wherein aregion of continuous edge surrounding regions corresponding to thetranslucent region is generated. On the other hand, in the objectexistence area in which objects such as medicine etc., are present,since an edge surrounding region is not formed by the light emitted fromthe backlight 314, a region of continuous edge surrounding regions isnot generated.

When the image processing of step 2-1 b described above is finished, aprocess to invert a selected area (selected area inversion process) isexecuted in step 2-1 c. With this, as shown in FIG. 27D, a regionincluding a print area selected as an edge surrounding region isinverted to a non-selected state. Subsequently, in step 2-1 d, an imageprocessing is executed in which a separately selected gray color image(hereafter also referred to as ‘gray image’) is overlapped in the lowerlayer of the image prepared by the processes up to step 2-1 c (see FIG.27E). This gray image has a size substantially matching the size of thesachet b, and is a completely monochrome image. In the basic image thatwas processed up to step 2-1 c, the gray image is disposed in the lowerlayer of the area where a sachet b to be inspected exists.

The image that was obtained from image processing of the step 2-1 ddescribed above is binarized in step 2-1 e, and subjected to a processto extract sections that are darker than other regions (object existencearea derivation process). Here, when the image obtained in step 2-1 d isbinarized, an object existence area where objects such as medicine arethought to be present is forming an area darker than the print area.Therefore, in step 2-1 e, an object existence area as shown in FIG. 27Fis extracted. By a sequence of processes according to step 2-1 a throughstep 2-1 e described above, the object existence area derivation processis completed.

When object existence area derivation process is finished as describedabove, in step 2-2, a process of outwardly expanding the objectexistence area is executed (FIG. 27G). Subsequently, in step 2-3, anarea demarcation process for creating a filter to exclude regions otherthan the areas expanded by the expansion process is executed in step 2-3(FIG. 27H). With this, it is possible to set a filter for masking sothat loss of mapping of objects such as medicines is not caused. Oncesetting of the filter is finished in 2-3, the inspection area definingprocess pertaining to step 1-2 is completed.

Once the inspection area defining process is completed, the control flowproceeds to the inspection image acquisition process according to step1-3 of FIG. 26. In the inspection image acquisition process, aninspection image for carrying out inspection of medicine from the imagelimited to within the inspection area demarcated by the sequencedescribed above is acquired. Specifically, in the image inspectionprocess, by applying the above-mentioned filter acquired in theinspection area defining process to the image obtained separately fromthe back lit image used for the basic image acquisition processdescribed above (hereafter also referred to as ‘back unlit image’), animage for inspection in which the inspection area is narrowed to minimumwill be obtained.

Here, the back unlit image used in the inspection image acquisitionprocess is obtained by photographing a sachet b disposed in theinspection unit 310 with the backlight 314 in an unlit state by theshooting means 18. When the back unlit image is photographed, thediffusion light emitting device 160 is set in a lit state. The backunlit image can be acquired at an optional timing before the inspectionof medicine is carried out in the image inspection process.Specifically, it is possible to photograph the back unlit image afteracquiring the back lit image and while executing a process up to theinspection area defining process. With this, it becomes possible toeffectively use the execution period of the inspection area definingprocess for photographing the back unlit image, and to speed up a seriesof inspection operations.

In the inspection image acquisition process of step 1-3, masking isperformed by applying the above-mentioned filter to the back unlit imagein order to prevent a loss of mapping of items such as medicine in theback unlit image. Thereafter, in step 1-4, an image inspection isperformed to detect the quantity and type of the medicine in the imageof the inside of the inspection area (image for inspection) narroweddown by masking in the inspection image acquisition process. In step1-4, matching is performed by referring to the database in which shapeinformation (edge information) and color information of the medicine tobe inspected have been previously registered, and it is checked whetherthe prescribed medicine is packaged in the sachet b or not.

The inspection result of the medicine inspection process explained aboveis displayed in a display format as shown in FIG. 29, for example, on adisplay device such as a monitor of a personal computer of a controldevice 330. Specifically, during execution of the medicine inspectionprocess, among the respective sachets b of a continuous body of sachetsB supplied for inspection, the back unlit image for each sachet b willbe displayed as a thumbnail in the order of completion of inspection, asshown in FIG. 29A. After the medicine inspection process is completed,if there is a sachet b containing excess or deficient quantity ofmedicine, the overall judgment is displayed as NG as shown in FIG. 29B.In this state, upon selecting (clicking) the inspection completionbutton, a log showing the inspection result is printed by a printer,which is not illustrated.

In a display state shown in FIG. 29B, upon selecting the display sizebutton, it is possible to switch the display size of the thumbnailimages showing each sachet b as shown in FIG. 29C. Further, by clickingthe thumbnail image showing each sachet b, the inspection result of eachsachet b can be checked individually as shown in FIG. 30.

Specifically, upon clicking the thumbnail images showing each sachet bin the display state shown in FIG. 29, an individual display window ofinspection result is displayed as shown in FIG. 30. In the individualdisplay window of inspection results, in addition to displaying thename, image, and quantity of the prescribed medicine, the detectionresult of each medicine is also displayed. Further, upon selecting theimage of medicine in the window, an enlarged image of that medicine isdisplayed as shown in FIG. 30, and information regarding the size isalso displayed. In addition, when displaying the individual displaywindow of inspection results, in case a medicine for which the imagedepicting the contour is not yet registered in the database isprescribed, an image cut out from the back unlit image used in themedicine inspection process will be displayed along with the medicinelist (see FIG. 30B).

As a result of medicine inspection process, if there is a medicine thatis included in the prescription information but not detected by theinspection, as shown in FIG. 31A, a button indicating that it was notdetected is displayed in the medicines list column of inspection resultsindividual display window. Upon selecting the button indicating that amedicine was not detected, a button by which an operator can determineby himself/herself whether a prescription drug is packaged in the sachetb or not is displayed as shown in FIG. 31B.

An operator can check whether the medicine has been packaged or not byusing the back unlit image of the sachet b displayed in the left columnof the individual display window of inspection results. Upon selectingthe OK button in a state shown in FIG. 31B, it is determined that theoperator made a judgment that the medicine is packaged in the sachet bin accordance with prescription, and the inspection result isdetermined. Upon selecting the NG button, it will be assumed that theoperator made a judgment that the prescribed medicine is not packaged insachet b, and the inspection results is determined. Further, uponselecting the original button, the decision of the operator made earlierby selecting the OK button or the NG button is retracted, and theinspection result will be restored to the judgment results of themedicine inspection process.

Further, as shown in FIG. 31 and FIG. 32, in the quantity displaysection provided at bottom right column of the individual display windowof inspection results, the quantity of a medicine that should bepackaged in sachet b, and the quantity of the medicine detected by themedicine inspection process are displayed in the form of a fraction, aswell as the determined result of whether the medicine is properlypackaged will be displayed. Specifically, if the quantity of medicinethat should be contained in sachet b is 6, and the medicine detected bythe medicine inspection process is 10, a display as illustrated in FIG.32A will be displayed. In this case, because it cannot be said that themedicine is properly packaged, NG is displayed as a determined result.On the other hand, if the quantity of a medicine that should be presentin the sachet b and the quantity of the medicine detected by themedicine inspection process are same, OK is displayed as in FIG. 32B.

As shown in the respective FIG. 31 and FIG. 32, in the identificationresult display section at bottom right column in the individual displaywindow of inspection results, the inspection result based on the contourshape and color of a medicine determined by the medicine inspectionprocess is shown. This identification result field also displays thequantity of a medicine that should be packaged in sachet b and thequantity of the medicine detected by medicine inspection process in theform of a fraction, and a determined result whether the medicine hasbeen properly packaged.

As explained above, in the medicine inspection device 300, a basic imagefor medicine inspection is acquired based on a back lit imagephotographed by illuminating the sachet b, which is disposed in theinspection unit 310, by the backlight 314 in the basic image acquisitionprocess. In the basic image, the inspection area is refined consideringthe characteristics that the region where the medicine is assumed toexist is photographed as a shadow and the other region is photographedas a translucent region emitting light in a dot pattern. That is, thetranslucent region emitting light in a dot pattern in the basic image isexcluded from the inspection area. Therefore, it is possible to minimizethe load of the control device 330 at the time of executing theinspection of a medicine in the image inspection process, and to enhancethe inspection accuracy and the execution speed of image inspection.

In the medicine inspection device 300 of this embodiment, by effectivelyutilizing a characteristic wherein a difference of whether a continuousregion is formed or not occurs in the basic image by changing a regionenclosed by the outline only by a predetermined amount based on thedifference whether it is a printed area where printing is done on sachetb or it is a region where the medicine is present, a printing areaexclusion process (in this embodiment, equivalent to object existenceregion derivation process described above) for excluding the printingarea from inspection area is executed. Therefore, in the medicineinspection device 300 of this embodiment, even if a sachet b withcharacters or the like printed thereon is fed, it becomes possible toaccurately and rapidly derive the quantity and/or type of a medicinewithout receiving the influence of printing.

In the medicine inspection device 300 of this embodiment, an example inwhich a light source 316 and a mesh member 318, which is disposedbetween the light source 316 and sachet b and has translucent holes ateach predetermined pitch, are provided as a backlight 314, but thepresent invention is not limited to this. That is, it can be anything aslong as it is possible to emit light in a dot pattern at eachpredetermined pitch over the entire illumination area by the backlight314, and it may be a configuration wherein light is emitted at eachpredetermined pitch by disposing light emitting diodes in a dot matrixpattern, for example. Also, the backlight 314 may also be a materialcapable of generating infrared laser light.

Further, the backlight 314 described above uses a light source capableof generating a light whose wavelength is same as or longer than that ofred light as a light source 316, and the linearity of the generatedlight is high. With this, in the back lit image photographed by shootingmeans 18, a region where medicine exists and the outline of the medicinecan be clearly identified in the basic image. Furthermore, thedot-patterned light emitted from the backlight 314 is also transmittedreliably in the printed region of sachet b, and the printed region canbe clearly identified in the back lit image. With this, it becomespossible to not only improve the image processing accuracy wheneliminating the printed area from the inspection area, but also toimprove the accuracy of medicine inspection. Moreover, from theviewpoint of translucency, it is preferable that the backlight 314 iscapable of generating a light whose wavelength is same as or longer thanthat of red light, but it may generate a light whose wavelength is lessthan that of red light.

Moreover, in the medicine inspection device 300 of this embodiment,elimination of a medicine-existing-region from the inspection area isprevented by executing the object existence region derivation process(elimination process) to expand the remained region by only apredetermined amount towards the outside in the expansion process in theinspection area defining process. With this, the accuracy of medicineinspection by the medicine inspection device 300 can be furtherenhanced.

<<Foreign Object Detection Process>>

As an execution means for executing the foreign object detection processdescribed above, a foreign object detection process means 350 isprovided. In addition, a medicine present area demarcation means 360 isprovided for demarcation of an area in which medicine is present in thesachet b that is disposed in the inspection unit 310. The foreign objectdetection process means 350 is provided in order to run the foreignobject detection process for detecting whether a sachet b containsobjects (foreign object) other than the medicine for inspection or not.In the foreign object detection process, in addition to a basic imageacquired by the medicine information detector 340 described above, aseparately prepared image for position recognition 365 is used. As shownin FIG. 33, the image for position recognition 365 has a positionrecognition area 366 having a size corresponding to the basic image. Allof the position recognition area 366 is provided with dot-patternedposition indicators 367 at a predetermined pitch. In addition, eachposition indicator 367 has coordinates.

By overlapping the position recognition area 366 of an image forposition recognition 365 and a basic image, the foreign object detectionprocessing means 350 can find out the position of mapping included inthe basic image from the coordinates assigned to position indicators367. Specifically, the foreign object detection processing means 350 canidentify the position of the mapping of the object by overlapping abasic image and an image for position recognition 365 and by extractingthe positional coordinates of a section in which the mapping of anobject such as medicine or the like present in the basic image and thedemarcated area are overlapped.

The medicine present area demarcation means 360 executes the process ofdemarcation of the area where the medicine exists in an image of asachet b containing medicine. The medicine present area defining means360 demarcates the area of medicine by a matching method such as aso-called shape base pattern matching or a gray pattern matching etc. Inthis embodiment, the medicine present area defining means 360 canexecute a shape base pattern matching and demarcate the medicineexisting area by carrying out a matching based on the information ofexternal shape (contour) already registered for a medicine of inspection(edge information).

Next, the foreign object detection process executed by a foreign objectdetection processing means 350 and medicine present area defining means360 is described in detail. As shown in FIG. 34, the steps of theforeign object detection process can be largely classified into threesteps that are an object existence area coordinate extraction process, amedicine coordinates group derivation process, and a foreign objectdetermination process. The object existence area coordinate extractionprocess of step 3-1 is a step in which the positional coordinate group,which exists within the area enclosed by the outline in the basic imageobtained by the medicine information detector 340 during medicineinspection process described above, is derived as the object existencearea coordinate group.

In the object existence area extraction process, as the first step 3-1a, an image processing is performed by overlapping an image (see FIG.35A) obtained from the object existence area derivation process executedin the inspection area defining process of the medicine inspectionprocess, and an image for position recognition 365 (see FIG. 33 and FIG.35B) described above. As a result, an image as shown in FIG. 35C isobtained. Then, in step 3-1 b, the foreign object detection processingmeans 350 executes a process in which, from the dot-patterned positionalcoordinates formed in the image for position recognition 365, thepositional coordinates included in the object existing area defined bythe object existence area derivation process are extracted as an objectexistence area coordinates group.

Once the object existence area extraction process of step 3-1 iscompleted as described above, the medicine coordinate group derivationprocess of step 3-2 is executed. In the medicine coordinates groupderivation process, as the first step 3-2 a, an image of amedicine-filled sachet b disposed in the inspection unit 310, which isphotographed by the shooting means 18, is used to perform a shape basepattern matching by the medicine present area demarcation means 360.Used for the image used in this process (hereafter also referred to as‘matching image’) is an image same as the back unlit image used in theimage inspection process of medicine inspection process described above,or an image photographed in a situation similar to the back unlit image,which is a situation in which the backlight 314 is switched off and thediffusion light emitting device 160 is switched on. In the medicinecoordinates group derivation process, the shape pattern matchingmentioned above is carried out for the matching image, and the area inwhich medicine exists (medicine present area) is demarcated as in FIG.35D.

Once the demarcation of the medicine present area in the image formatching is completed as described above, an image processing foroverlapping the above-mentioned matching image and the above-mentionedimage for position recognition 365 is implemented in step 3-2 b. In step3-2 c, a process is executed in which, among the dot-patternedpositional coordinates formed in the image for position recognition 365,the positional coordinates included in the medicine present areademarcated in step 3-2 a are extracted as medicine area coordinates.With this, the medicine coordinates group derivation process iscompleted, and proceeds to the foreign object determination process instep 3-3.

In the foreign object determination process, whether a foreign object ismixed in sachet b or not is determined on the basis of the results ofthe object existence area coordinate extraction process and medicinecoordinates group derivation process. That is, in the foreign objectdetermination process, the object existence area coordinates groupderived in step 3-1 described above and the medicine area coordinatesgroup derived in step 3-2 are cross-checked by foreign object detectionprocessing means 350, and the dot-patterned positional coordinateslocated in the matching coordinates in both are erased from the image.As a result, if the positional coordinates that are not present in theobject existence area coordinates group exist in medicine areacoordinates group, it is possible to retain the dots showing thepositional coordinates as shown in FIG. 35E, and infer the presence of aforeign object in that coordination position.

As described above, in the medicine inspection device 300, by executingan object existence area coordinates group extraction process, theregion wherein objects such as medicine etc. exist can be obtained fromthe outline present in the basic image as a form of object existencearea coordinates group. Further, by a medicine coordinates groupderivation process that is separately executed, a medicine-existingregion can be obtained as a form of medicine area coordinates group. Inthe medicine inspection device 300, it is possible to determine whethera foreign object other than medicine is present in a sachet b or notbased on whether the object existence area coordinates group andmedicine area coordinates group match each other. Therefore, accordingto the medicine inspection device 300, it is possible to not only checkthe medicine quantity or type, but also detect the contamination of aforeign object other than medicine with certainty.

<<Medicine Master Construction Process>>

In addition to the medicine inspection process and the foreign objectdetection process described above, the control device 330 can alsoexecute a process for constructing a medicine master 370 (medicinemaster construction process) in which the master information of themedicine to be inspected is registered in the computer. The medicinemaster 370 includes a contour image database 372 in which the contourimage of a medicine is registered for review. In the contour imagedatabase 372, the contour image of a medicine is registered byclassifying into each constituting surface (front, rear and side).

Here, in the medicine inspection device 300 of this embodiment, themedicine master can be displayed by selecting the medicine master buttonthat is displayed by selecting (clicking) the menu button, in a statewhere the operational screen as shown in FIG. 36A is displayed on themonitor of the computer of the control device 330. Further, uponclicking the analogous medicine master button in the same screen, a listof medicines having a similar appearance can be listed as shown in FIG.36B.

If the medicine master button is clicked in the operation screen of FIG.36A, the master information for each medicine can be displayed as shownin FIG. 36C. In this master display screen, in addition to themedicine-related information such as name and code number of a medicine,the contour image of the medicine described above is displayed for eachconstituting surface.

When executing the medicine master construction process, a photographingjig 380 shown in FIG. 37 is employed. The photographing jig 380 includesa stage 382 for mounting a medicine, and a pedestal 384. Stage 382 isformed from a white-colored translucent resin. Stage 382 is divided intofour regions by a central line 386 formed so as to extend in thevertical direction and the lateral direction in the center of theregion. Each region formed in the sage 382 functions as an imaging zoneassociated with each side of the medicine to be photographed. In stage382, positioning guide 388 is provided in each region to help dispose amedicine at a predetermined location. The positioning guide 388 isformed of dot-patterned marks drawn on the resin plate of the stage 382.The size of each dot of positioning guide 388 is smaller than theexpected size of the medicine and foreign object being supplied forinspection.

The pedestal 384 is of a size that can be mounted on a transportationmeans 12 that is provided for conveying a sachet b to the inspectionunit 310. A stage installation part 385 is provided in the middle of thepedestal 384 for fixing the resin plate of the stage 382. Therefore, bylaying a medicine with its side associated with each imaging area facingupwards (towards shooting means 18) in each imaging zone formed in stage382, and moving the stage 382 mounted on the pedestal 384 to theinspection unit 310 by the transportation means 12, the image of eachsurface of the medicine can be taken at the same time under the sameconditions.

Further, all four sides of the stage installation part 385 are enclosedby a black colored or dark colored resin of the pedestal, and allowpassage of light in the vertical direction. Therefore, when thephotographing jig 380 is moved to the inspection unit 310 andphotographed by the shooting means 18, a medicine can be vividly imaged.If imaging is performed with the backlight 314, which is disposed on theback of (below) the inspection unit 310, switched on, a medicine placedon the stage 382 is photographed with a clearly distinct contour.

Next, the method of executing the medicine master construction processis explained step-by-step. As shown in FIG. 39, the medicine masterconstruction process is executed through the following three steps:outline derivation process, original image photographing process andcontour image cutout process. The outline derivation process accordingto step 4-1 is a process involving photographing a medicine placed onstage 382 with the backlight 314 switched on, and deriving the outlineof the medicine from that image. Specifically, in the outline derivationprocess, first, in step 4-1 a, the photographing jig 380 with themedicine to be imaged placed on stage 382 is moved to the inspectionunit 310. Then, stage 382 is irradiated by the backlight 314, and themedicine placed on stage 382 is photographed to obtain an outlinederivation image. Subsequently, in step 4-1 b, based on the outlinederivation image, an imaging processing for deriving an outline for eachsurface of the medicine is executed.

When the outline of the medicine is derived in step 4-1, an originalimage that serves as the base of a contour image of the medicine isphotographed in the original image photographing process in step 4-2.That is, in step 4-2, the imaging is done by the shooting means 18 withthe backlight 314 switched off, and the diffusion light emitting device160 switched on to irradiate the stage 382. With this, as shown in FIG.38, an index 387 is displayed along with stage 382 and medicine. Index387 is displayed on a side of the stage 382, and is used for positionidentification of stage 382 and a medicine disposed on stage 382 from arelation with the positioning guide 388 provided on stage 382. Index 387is also used as an index for recognizing the size of a medicine.

Once the original image for creating a contour image is acquired in step4-2, it will proceed to the contour image cutout process in step 4-3. Instep 4-3, in a state wherein the outline derivation image obtained instep 4-1 and the original image obtained in step 4-2 are overlapped, animage processing is executed to cut out an area corresponding to thearea surrounded by the outline of the medicine from the original image.With this, contour image for each surface of the medicine is obtained.

A contour image obtained as described above is classified for eachconstituting surface of the medicine, and registered in a contour imagedatabase 372. The images of the contour image database 372 that wasconstructed in such a manner are used for displaying for browsing whendisplaying the inspection results of medicine inspection process, etc.,mentioned above.

As described above, in the medicine inspection device 300, a region forcutting out the image of the medicine is identified by an outline on thebasis of a back lit image (irradiated image) that includes a medicine asshadow, and from a back unlit image (back non-irradiated image) in whichthe medicine is vividly included, a section corresponding to the areaenclosed by the outline is cut out. With this, a region of the backunlit image where a medicine is included can be cut out properly.Accordingly, in the medicine inspection device 300, a vivid contourimage of a medicine can be obtained easily and with high accuracy, and acontour image database 372 can be constructed.

In this embodiment, stage 382 used for photographing the image of amedicine has a plurality of imaging zones corresponding to eachconstituting face of a medicine, and it is possible to place a medicinein each imaging zone such that the face associated with each imagingregion is oriented towards the shooting means 18. Therefore, if an imageis taken in a state wherein the stage 382 mounted with a medicine isplaced on the pedestal 384 and reached the inspection unit 310, thecontour image of each face of the medicine can be acquired at the sametime and under the identical conditions. This allows minimizing theefforts and time required for acquisition of contour image of themedicine, and it is possible to homogenize the shade or the like of thecontour image of each surface.

Further, as described above, the stage 382 is provided with positioningguides 388 for positioning a medicine at a predetermined position. Withthis, a medicine can be guided to be in a suitable position when themedicine is photographed for construction of a contour image database.Moreover, because the size of the positioning guide 388 is madeadequately smaller than the expected size of a medicine or foreignobject, it is possible to easily and accurately distinguish between thepositioning guide 388 and medicine or the like in the image photographedfor constructing a contour image database 372, and by erasing thepositioning guides 388 from the image or the like, it becomes possibleto prevent the positioning guides 388 from getting imaged in the contourimage of the medicine. Moreover, this embodiment illustrated an examplehaving a configuration of providing positioning guides 388 and makingthe positioning guides 388 very small, but the present invention is notlimited to this. In other words, a configuration having no positioningguides 388, or making them of about the same size as medicine etc., isalso possible. If positioning guides 388 are not provided, it isdesirable to provide some mark or the like for guiding the placingposition of the medicine. In addition, if the size of a positioningguide 388 is made almost the same as the medicine or the like, it isdesirable to provide a configuration capable of reliably distinguishingthe contour image of the medicine and the positioning guides 388.

In this embodiment, since the stage 382 is made of white color, even formedicines of dark colors such as green, black, or etc., for example, itis possible to clearly distinguish between the stage 382 and a medicinein the image taken for contour image acquisition. Thus, a contour imageof a medicine can be acquired easily and accurately, and the accuracy ofthe contour image database can be improved. Moreover, stage 382 is notnecessarily required to be white, and it may also be of other colors. Inaddition, in order to enable easy identification of black ordark-colored medicines, it is desirable that stage 382 is of a lightcolor shade.

The medicine inspection device 300 of this embodiment described aboveillustrated an example of a configuration in which the shooting means 18is used as a shooting means for a back lit image for photographing theimage of a medicine in an irradiated state, and also as a shooting meansfor back unlit image for photographing a medicine wherein the rear sideof the inspection unit is not irradiated, however, the present inventionis not limited to this, and it is also possible to provide aconfiguration in which the shooting means for back lit image and theshooting means for back unlit image are configured from differentimaging devices.

Specifically, it is possible to provide a configuration wherein aseparate imaging device is provided in a place where space is availablesuch as the upstream of the diffusion light emitting device 160, and touse this imaging device as a shooting means for back unlit image and usethe shooting means as the shooting means for back lit image. It is alsopossible to provide a separate imaging device in an obliquely upwarddirection with respect to the diffusion light emitting device 160, andto use this imaging device as a shooting means for back unlit image anduse the shooting means as the shooting means for back lit image. In suchcase, because the image taken by the shooting means for back unlit imageis an image in which a medicine on the inspection unit 310 isphotographed obliquely from above, it is preferable to consider measuressuch as compensating the image so as to become similar to thatphotographed from the front side.

Further, an imaging device of high pixel number capable of photographingthe contour of a medicine vividly by imaging the medicine in an unlitstate can be provided as a shooting means 18, and this shooting means 18can be used as a shooting means for back unlit image and as a shootingmeans for back lit image at the same time. When such a configuration isadopted, an image obtained by photographing a medicine in the irradiatedstate is thought to be of excessive quality for the purpose ofextracting the contour of the medicine. Therefore, when using an imagingdevice of high resolution as a shooting means 18, it is preferable totake measures such as image processing or the like to transform theimage of the medicine photographed in an irradiated state into a lowerquality image when extracting the outline of the medicine. Further, whenproviding a shooting means for back unlit image and a shooting means forback lit image separately as described above, the imaging conditionssuch as illumination degree may be changed when photographing byshooting means for back lit image and when photographing by shootingmeans for back unlit image.

<<Modified Example of Medicine Master Construction Process>>

The method of constructing a medicine master is not limited to themethod described above, and it is also possible to construct a medicinemaster by using an image corresponding to medicine that was cut out asper the control flow shown in FIG. 70, for example. The method shown inFIG. 70 is described step-by-step below.

The image acquiring method for medicine master construction shown inFIG. 70 involves cutting out the image of a medicine placed in theinspection unit 310 by using a back lit image obtained by photographingwith the shooting means 18 in an irradiated state in which theinspection unit 310 is irradiated by backlight 314, and a back unlitimage obtained by photographing, without irradiating the inspection unit310 by the backlight 314, by shooting means 18 in a back non-irradiatedstate by switching off the diffusion light emitting device 160. In thecontrol flow shown in FIG. 70, in step 9-1, an image processing is firstperformed to obtain a back lit binarized image for later use.Specifically, in step 9-1, the back lit image is RGB resolved, and fromamong the obtained back lit R channel image, back lit G channel image,and back lit B channel image, at least one is selected as the back litsingle channel image. Then, the selected back lit single channel imageis subjected to binarizing image processing. In this embodiment, backlit R channel image is selected as the back lit single channel image,and this is subjected to binarizing image processing to get a back litbinarized image. The threshold value of binarization is determined fromthe minimum value of the brightness histogram, and an area of lowbrightness is assumed as a provisional medicine region, and an area ofhigh brightness is considered as a provisional background region.

In step 9-2, the provisional medicine region and provisional backgroundregion acquired in step 9-1 are used for deriving the informationrelated to brightness distribution in the back lit single channel image.Specifically, in step 9-2 a, the brightness distributions of medicineand background images in the back lit single channel image is derivedunder the assumption that it is Gaussian distribution (normaldistribution) (see FIGS. 71A and 71B). In step 9-2 b, the mean value Mmand standard deviation σm for the brightness distribution of provisionalmedicine region and the mean value Mb and standard deviation σb for thebrightness distribution of the provisional background region arederived.

Specifically, the brightness of the region corresponding to the medicineis lower than the brightness of the region corresponding to thebackground, and they are mutually different. Therefore, as shown in thegraphs of FIGS. 71A and 71B, as brightness distribution of back litsingle channel image, two peaks substantially forming normaldistribution appear. Of these two peaks, the peak of lower brightnessshows the brightness distribution of a region corresponding to themedicine, and the peak of high brightness shows the brightnessdistribution of a region corresponding to the background. Therefore, inthe graph of FIG. 71, the mean value of the lower brightness peakbecomes the mean value Mm, and the mean value of the higher brightnesspeak becomes the mean value Mb. The standard deviations σm and σb can bederived from the graph of FIG. 71.

Once the information related to brightness distribution is derived asdescribed above, the control flow proceeds to step 9-3. In step 9-3through step 9-5, in order to suppress the selection omission of aregion corresponding to medicine, under the concept shown in FIG. 71B, amedicine image cut-out mask, which is for providing a masking to theregion corresponding to the background existing on the high brightnessside, is formed on the basis of brightness. Brightness that becomes thereference for preparing a medicine image cut-out mask is determinedbased on magnitude relationship between brightness (Mm+3σm) andbrightness (Mb−3σb).

Specifically, in step 9-3, as shown in FIG. 71A, it is checked whether arelation of Mm+3πm≧Mb−3σb is established or not. When this relationshipis established, the Gaussian distribution corresponding to the medicineoverlaps with the Gaussian distribution corresponding to the background,but if an image for the brightness range for the medicine is acquired byadding 3σm to Mm, the probability of obtaining a region corresponding tothe medicine without omission of image is thought to be high. Therefore,when a relationship of Mm+3σm≧Mb−3σb is established, the control flowproceeds to step 9-4, and with brightness Mm+3σm as reference, amedicine image cut-out mask is formed for providing masking to a regionwith a brightness greater than reference brightness.

On the other hand, if the relationship of Mm+3σm Mb−3σb is notestablished in step 9-3, that is, in case of Mm+3σm<Mb−3σb as in FIG.71B, the Gaussian distribution corresponding to the medicine will beseparated from the Gaussian distribution corresponding to thebackground. However, in order to select an image area corresponding tothe medicine without omission, it is desirable to mask a region having abrightness greater than Mb−3σb located in the lower limit side of thebrightness distribution of the background. Therefore, when the relationof Mm+3σm<Mb−3σb is established, the control flow proceeds to step 9-5,and a medicine image cut-out mask for masking a region brighter thanMb−3σb is formed.

If a medicine image cut-out mask is formed in step 9-4 or step 9-5 asdescribed above, the control flow proceeds to step 9-6. In step 9-6,based on the medicine image cut-out mask, an image processing to cut outthe back unlit image is executed. That is, the region set for masking bythe medicine image cut-out mask is assumed to be a region where themedicine does not exist. Therefore, by applying a medicine image cut-outmask to the back unlit image, an image of the medicine can be obtainedby cutting out a region that is not masked in the back unlit image.

By cutting out a back unlit image based on the medicine image cut-outmask that was set as described above, the image of a medicine disposedin the inspection unit 310 can be acquired without omission, and bythis, the inspection accuracy of the medicine inspection device 300 canbe further improved.

<<Perforation Detection Process>>

As explained above in the first embodiment, when supplying a sachet b tothe inspection unit 310, it is necessary to dispose a sachet b in asuitable position with respect to the inspection unit 310 in order toprevent deterioration in the inspection accuracy of the medicine. Whensupplying sachet b in a form of a continuous body of sachets formed by acontinuum of sachets b, even if the deviation between the sachet b andinspection unit 310 is considered to be extremely small in the initialstages, the deviation will accumulate by sending sachets b sequentially,and there is a possibility that the positional deviation of sachet bwith respect to the inspection unit 14 becomes large enough to result ininspection failure. To overcome such problems, it is desirable to detecta boundary d (see FIG. 40) that is formed by perforations etc. betweenthe longitudinal sealing parts s1 and s1 of two continuous sachets b andb in the length direction of the continuous body of sachets B, and toposition a sachet b with respect to the inspection unit 310 on the basisof this boundary d.

Therefore, similarly to the medicine inspection device 10 of theabove-mentioned first embodiment, the medicine inspection device 300 ofthis embodiment has a configuration that enables detecting the boundaryd between adjacent sachets b. Specifically, the medicine inspectiondevice 300 has a configuration in which a control device 330 is providedwith a boundary position detection means 400. Below, the boundaryposition detection means 400 will be explained in detail.

The boundary position detection means 400 is capable of executing aboundary position derivation process for deriving a boundary d formed ina continuous body of sachets B based on an image obtained byphotographing a continuous body of sachets B. As shown in FIG. 41, theboundary position derivation process is executed via the followingprocesses: image acquisition process; content image exclusion process;outline detection process; outline expansion process; and longitudinalseal area detection process.

Specifically, when executing the boundary position derivation process,first, an image acquisition process to acquire an image (hereafter,called as ‘original image for boundary derivation’) of the continuousbody of sachets B by shooting means 18 is executed in step 5-1. Then, instep 5-2, a content image exclusion process is executed to filter out amapping of medicine or the like contained in sachet b from the originalimage for boundary derivation by image processing. Specifically, basedon either one or both of brightness information or color information ofthe original image for boundary derivation, a content such as medicinepacked in sachet b is identified, and the image information of a sectioncorresponding to the content is removed. In this embodiment, based onthe brightness information of the original image for boundaryderivation, a content image exclusion process is executed. Here, thecontent image exclusion process does not need to be performedimmediately after acquisition of original image for boundary derivation,and it may be executed in the operation stage before executing thelongitudinal seal area detection process, which is described later indetail.

In step 5-3, the original image for boundary derivation, after thecontent image exclusion process, is subjected to outline detectionprocess. The outline detection process is executed by matching usingmethods such as the so-called shape base pattern matching, or graypattern matching etc. The boundary position detection means 400 of thisembodiment can detect an outline included in the original image forboundary derivation by shape base pattern matching.

Once the step 5-3 is completed, the boundary position detection means400 executes the outline expansion process in step 5-4. The contour lineexpansion process is an image processing for acquiring an image forvertical seal area detection by executing an image processing ofexpanding a region surrounded by the outline, which was detected byoutline detection process, outwardly only by a predetermined amount.

Here, within a rectangular area in which longitudinal sealing is formedin the continuous body of sachets B, a large number of dot-patternedseal marks are formed in the short-hand direction (width direction) ofthe continuous body of sachets B. Therefore, if a region formed by anoutline of the seal marks is expanded, each region mutually overlaps toform a region extending as a whole in the vertical seal direction(hereafter also referred to as ‘vertical seal area’).

In light of these characteristics, in step 5-5, the boundary positiondetection means 400 executes a process (the longitudinal seal areadetection process) to detect an image region corresponding to thevertical seal area from the vertical seal detection image obtained instep 5-4. If the vertical seal area is detected by this, subsequently instep 5-6, a process is executed to derive the intermediate position ofthe vertical seal area as the position of the boundary d between theadjacent sachets b (boundary position derivation process).

As described above, in the medicine inspection device 300 of thisembodiment, by expanding an outline towards the outside of a detectionarea by an outline expansion process to make a plurality of detectionareas overlapped with one another, accuracy is improved to determinewhether the detected outline and detection area in the outline detectionprocess are due to dot-patterned seal marks of the longitudinal sealingpart. Therefore, according to the medicine inspection device 300,identification of the position of the vertical seal applied to acontinuous body of sachets B, and identification of the boundaryposition between adjacent sachets b can be performed with excellentaccuracy.

Further, in the medicine inspection device 300 of this embodiment, byexecuting the content image exclusion process in an operation stageprior to executing the longitudinal seal area detection process, theitem stored in a sachet b is identified based on the brightnessinformation or color information of an image used for deriving theposition of the boundary, and the image information of a sectioncorresponding to the content is removed. This makes it possible tosuppress the possibility of erroneously detecting the outline of contentas the outline of the longitudinal sealing part, and to further improvethe accuracy of detecting the perforations of boundary d.

Moreover, in this embodiment, the execution accuracy and execution speedof longitudinal seal area detection process is improved by previouslyremoving the image information of a section corresponding to the contentby executing the content image exclusion process, but the presentinvention is not limited to this, and it is also possible not to executethe content image exclusion process.

<<Modified Example of Perforation Detection Process>>

The method of executing perforation detection process by the boundaryposition detection means 400 is not limited to the method describedabove, and it may also be a method that is executed in accordance withthe control flow shown in FIG. 69, for example. The control flow of FIG.69 is described below.

In the boundary position detection means 400, it is possible to derivethe position of boundary by executing each of the flowing processes.That is, in step 8-1, the longitudinal edge detection process is firstexecuted. That is, an image analysis is performed for detecting edgesfrom the image of sachet b photographed by shooting means 18 (originalimage for boundary derivation). Among the edges detected by this, theoutline extending in the vertical direction is detected as a verticaledge.

Once detection of the vertical edge is completed in step 8-1, thecontrol flow executes a longitudinal edge selection process in step 8-2.The longitudinal edge selection process is a process to select avertical edge, among the vertical edges detected in step 8-1, that islikely to be a boundary d and the longitudinal sealing parts s1 and s1adjacent to the boundary d. The longitudinal edge selection processselects edges, among the vertical edges detected in step 8-1, that islonger than a predetermined length as a candidate of boundary d andvertical edges corresponding to the longitudinal sealing part s1 and s1adjacent to the boundary d. Next, the control flow proceeds to step 8-3.

In step 8-3, an edge area joining process is performed. The edge areajoining process combines, among a plurality of vertical edges selectedby the longitudinal edge selection process, the region in which theinterval between vertical edges fits within a predetermined interval,which is set based on the width of longitudinal sealing part, as edgeareas. That is, if the interval between vertical edges is larger than apredetermined error range with the interval between the longitudinalsealing parts s1 and s1 as reference, or if smaller than that, it islikely that the vertical edge selected in step 8-2 is not a boundary dor does not correspond to longitudinal sealing parts s1 and s1.Thereupon, the regions that fit within a predetermined interval, whereinthe interval between the vertical edges is set using the width of thelongitudinal sealing part as reference, are searched and joined as edgeareas.

When the joining of edge areas is completed as described above, thecontrol flow proceeds to step 8-4, and the boundary position recognitionprocess is executed. A boundary position confirmation process is aprocess for checking whether the central portion of the edge area joinedin the edge area joining process of step 8-3 is valid as a position ofthe boundary d between the longitudinal sealing parts. With this, theboundary d can be easily and accurately detected.

Moreover, when the processes of step 8-1 through step 8-4 cannot beproperly executed (error state) in the perforation detection processaccording to this modification example, it may be configured to notify auser of a failure to detect boundary d, but it may also be configured toperform detection of perforations (boundary d), for example, by methodsaccording to the control flow shown in FIG. 41, or by other methods.

In the method of perforation detection process described above, boundaryd is to be derived by focusing on the features of a continuous body ofsachets B in which longitudinal sealing parts s1, s1, and the boundary dformed between the longitudinal sealing parts s1 and s1 extend in thevertical direction and can be detected as a vertical edge that extendslonger than a predetermined length, as well as the vertical edgecorresponding to longitudinal sealing part and the boundary fit within apredetermined interval. Therefore, in the method of perforationdetection process described above, the position of the boundary d can bederived easier and more accurately compared to a case of deriving theboundary by a simple image analysis.

<<Method of Aligning the Top Sachet Position at the Time of ContinuousPrescription>>

In the medicine inspection device 300 of this embodiment, a continuousbody of sachets B formed by a continuum of many sachets b can besupplied sequentially to inspection unit 310, and checked if a medicinehas been packaged according to prescription. Here, when a medicine ispackaged in the form of a continuous body of sachets B, in addition toforming different continuous body of sachets B for each prescription, acontinuous body of sachets B may be also formed by a continuum ofsachets b of multiple prescription doses. Thus, if sachets b ofdifferent prescriptions are present in one series of a continuous bodyof sachets B, one or a plurality of empty sachets are formed between thesachets b of the former prescription and sachets b of the latterprescription as shown in FIG. 40. Further, in a predetermined positionof an empty sachet b, a bar code providing information such asprescription information (identification label) is added.

In the case of including a continuum of sachets b of differentprescriptions is one series as described above, when sachets b of latterprescription following an empty sachet b is supplied to the inspectionunit 310 after inspection of sachets b of the former prescription iscarried out, it is necessary to position the sachet b precisely withrespect to inspection unit 310 when performing inspection for the latterprescription. Therefore, when sachets b of multiple prescriptions areincluded in a single continuous body of sachets B, a medicine inspectiondevice 300 is configured as described below in order to determine theposition of a prescription sachet b (head feeding) that follows an emptysachet.

Specifically, the medicine inspection device 300 includes anidentification mark recognition means 410 for recognizing theidentification marks attached to an empty sachet b. In this embodiment,as an identification mark recognition means 410, a bar code readercapable of reading a bar code by generating laser light is used. Inaddition, the identification mark recognition means 410 is disposed inthe upstream of the direction in which the continuous body of sachets Bis conveyed by the transportation means 12 with respect to theinspection unit 310.

A sachet positioning means 420 is provided to the control device 330.The sachet positioning means 420 can determine the position of amedicine-containing sachet b existing in the downstream of the emptysachet b with respect to inspection unit 310 based on the recognizedposition where an identification mark (bar code) was recognized byidentification mark recognition means 410, i.e. installation position ofthe identification mark recognition means 410. Specifically, at theinstant when an identification mark is recognized by identification markrecognition means 410, the sachet positioning means 420 infers that anempty sachet b has reached directly below the identification markrecognition means 410.

Here, the interval between identification mark recognition means 410 andinspection unit 310, and the size of sachet b are previously determinedby sachet positioning means 420. Therefore, at the instant when an emptysachet b has reached directly below the identification mark recognitionmeans 410, the sachet positioning means 420 can derive how much acontinuous body of sachets B should be moved towards the inspection unit310 so that a sachet b of the next prescription can reach the inspectionunit 310. Then, the sachet positioning means 420 sends the continuousbody of sachets B towards the inspection unit 310 only by that lengthrequired for a sachet b of the next prescription to reach the inspectionunit 310. Accordingly, a prescription sachet following an empty sachet bcan be positioned with respect to the inspection unit 310 (headfeeding). Therefore, in the medicine inspection device 300 of thisembodiment, even for a case such as forming an empty sachet in themiddle of a continuous body of sachets B for continuous prescriptionetc., as described above, with regard to a medicine-filled sachet bexisting in the downstream of an empty sachet b, it becomes possible toavoid lowering of the inspection accuracy due to a decrease in thepositioning accuracy with respect to the inspection unit 310.

In this embodiment, an example was presented in which a medicineinspection device 300 is capable of not only medicine inspectionprocess, but also foreign object detection process, medicine masterconstruction process, and perforation detection process, however, thepresent invention is not limited to this, and it may also exclude afunction to perform all or part of processes except for the medicineinspection process.

It is also possible to use the medicine inspection device 300 of thisembodiment instead of the medicine inspection device 10 in the medicinepackaging device 100 of the first embodiment described above.

Modification Examples

Below, modification examples that can be applied to either one or bothof the medicine inspection devices 10 and 300 shown in the embodimentsabove will be described in detail with reference to diagrams. In thedescription below, the modification examples applicable to either one orboth of the medicine inspection devices 10 and 300 will be describedtaking the medicine inspection device 300 as an example unless otherwiserestricted.

<<Fixing Device and Oscillation Operation>>

In both of the medicine inspection devices 10 and 300 described above,by vibrating a continuous body of sachets B (sachets b) in a horizontaldirection on the way to the inspection units 14 and 310 from theupstream of conveying direction, it is possible to overturn and dispersea medicine by the time it reaches the inspection units 14 and 310. Here,if a sachet b is heavy because it contains many medicines or the like,the sachet b may slip in the conveyance path and may not be oscillatedwell even when the transportation means 12 is operated so as to performan oscillating operation as described above. Consequently, it ispossible that a sachet b is not correctly disposed in the inspectionlocation after oscillation, and accurate imaging and inspection may notbe performed. In order to avoid such a situation, it is preferable totemporarily secure the end of a continuous body of sachets B.

By further explaining with the medicine inspection device 300 as anexample, a fixing device 500 as shown in FIG. 42 and FIG. 43 is providedto the introduction unit 304. As shown in FIG. 44 through FIG. 46, afixing device 502 equipped with a driving mechanism similar to thefixing device 500 is also provided in the ejection unit 305. Fixingdevices 500 and 502 are provided with pressing pieces 504 and 506capable of moving up/down with respect to a horizontal surface 304 a and305 a in which a continuous body of sachets B passes through in theintroduction unit 304 and ejection unit 305. Usually, the pressingpieces 504 and 506 are located above the horizontal surfaces 304 a and305 a with a clearance in which a continuous body of sachets B can passthrough. When it is necessary to temporarily fix a continuous body ofsachets B, the pressing pieces 504 and 506 are lowered and pressedagainst the horizontal surfaces 304 a and 305 a. With this, it becomespossible to hold and fix a continuous body of sachets B existing in thegap between the horizontal surfaces 304 a, 305 a and pressing pieces504, 506.

It is possible to use any kind of operating mechanism and installationposition of the fixing devices 500 and 502. That is, apart from theconfiguration to integrally hold the belt of the transportation means 12and a continuous body of sachets B, the fixing devices 500 and 502 canbe of type shown in FIG. 42 through FIG. 46, for example. Namely, thefixing devices 500 and 502, on the side of the horizontal surfaces 304 aand 305 a of the introduction unit 304 or ejection unit 305, haveswinging pieces 512 and 514 supported so as to oscillate around theshaft body 508 and 510 such as bolt or pin. Pressing pieces 504 and 506have been integrally formed in the tip section of the swinging pieces512 and 514. Further, drive shafts 520 and 522 of solenoids 516 and 518are connected to the swinging pieces 512 and 514. By moving the driveshafts 520 and 522 back and forth, the swinging pieces 512 and 514 canbe oscillated, and the pressing pieces 504 and 506 provided in the tipsection can be moved up and down.

Next, the oscillation operation for oscillating a continuous body ofsachets B in the horizontal direction so as to disperse a medicinepackaged in a continuous body of sachets B (sachet b), and coordinatedoperation with fixing devices 500 and 502 will be explained. Foroscillation operation, an oscillation method P1 involving firstoscillating a sachet toward the introduction unit 304 followed byoscillating it to return to the ejection unit 305, and a oscillationmethod P2 involving first oscillating a sachet to the ejection unit 305followed by oscillating it to return to the introduction unit 304 may beconsidered. When oscillating a continuous body of sachets B by theoscillation method P1, the continuous body of sachets B is to be fixedby the fixing device 500 provided on the introduction unit 304 side, andthe fixing by the fixing device 502 provided on the ejection unit 305side is to be released. When oscillating a continuous body of sachets Bby the oscillation method P2, the continuous body of sachets B is to befixed by the fixing device 502 provided on the ejection unit 305 side,and the fixing by the fixing device 500 provided on the introductionunit 304 side is to be released. Thus, it is possible to oscillate acontinuous body of sachets B without damaging it.

<<Upright-State Elimination Means>>

The above embodiment illustrated an example of providing anupright-state elimination means 110 provided with a roller 114 a at thetip of an arm 114 for overturning an upright medicine in a sachet b, butit is not limited to the configuration described above, and it is alsopossible to have an upright-state elimination means 530 shown in FIG.50, and one or more of it can be provided in the upstream of theinspection unit 310 as shown in FIG. 47 through FIG. 49. Specifically,the upright-state elimination means 530 consists of an arm 532, and acontact part 534 having an approximately ‘V’ shape in the side view isprovided at the end of the arm 532. Similar to the arm 114 of theabove-mentioned upright-state elimination means 530, the arm 532 isinstalled so as to freely rotate with respect to a spindle 536 that isprovided so as to be transverse to the conveyance path of the packagingpaper. Further, the arm 532 is biased towards the conveyance path by aspring 538. Accordingly, with respect to the surface of the packagingpaper passing through the conveying path, the contact part 534 can becontacted with the packaging paper by an appropriate strength that doesnot damage the packaging paper and the medicine.

The contact part 534 consists of an introduction side sloping surface540 inclining towards the introduction unit 304, and a dispense sidesloping surface 542 inclining towards the ejection unit 305. The angleθ1 formed between the introduction side sloping surface 540 and theconveyance path formed by the transportation means 12 and a continuousbody of sachets B (sachet b) traveling on this, and the angle θ2 formedbetween the conveyance path and dispense side sloping surface 542 areboth acute angle.

<<Another Modified Example of Upright-State Elimination Means>>

The above-mentioned upright-state elimination means 110 and 530 are onlyone embodiment of the present invention, and it is also possible to havea different one. Specifically, an upright-state elimination means 700shown in FIG. 75 is comprised of a contact part 702. The contact part702 consists of an introduction side sloping surface 704 and dispenseside sloping surface 706. The introduction side sloping surface 704 anddispense side sloping surface 706 have a configuration similar to theintroduction side sloping surface 540 and dispense side sloping surface542 respectively forming the contact part 534 of the upright-stateelimination means 530 described above. Therefore, a detailed descriptionwill be omitted.

The upright-state elimination means 700 is characterized by beingprovided with a medicine leveling unit 708 in addition to theintroduction side sloping surface 704 and the dispense side slopingsurface 706 described above. The medicine leveling unit 708 is installedbetween the introduction side sloping surface 704 and dispense sidesloping surface 706. The medicine leveling unit 708 is comprised of aspindle 710 and a bead member 712. Spindle 710 is a shaft body providedso as to extend along a ridge formed in the boundary section between theintroduction side sloping surface 704 and dispense side sloping surface706. That is, with respect to the installation condition of theupright-state elimination means 700, the spindle 710 is installed so asto be substantially orthogonal to the traveling direction of thecontinuous body of sachets B.

The bead member 712 is configured by such as abacus bead or pearl likebeads. In this embodiment, a hexagonal cross-section-shaped orapproximately diamond-shaped bead having an appearance as though bottomof two cones have been joined, such as an abacus bead, is used as a beadmember 712. The bead member 712 is mounted so as to slide with respectto the spindle 710.

If such a configuration is adopted, by the reciprocation of a continuousbody of sachets B, the bead member 712 will slide along the spindle 710while contacting the medicine. The bead member 712, while moderatelycontacting the medicine while sliding in the axial direction in thismanner, can overturn a medicine in an upright condition so thatinspection can be done easily.

<<Introduction Operation of a Continuous Body of Sachets>>

By providing an upright-state elimination means 530 of a shape describedabove, not only the operation of sending a continuous body of sachets Bfrom the introduction unit 304 towards the ejection unit 305 (forwardoperation), but also when performing an operation for sending thecontinuous body of sachets B in a direction opposite to this (reverseoperation), the continuous body of sachets B flows smoothly withoutclimbing onto the upright-state elimination means 530. Therefore, byproviding the upright-state elimination means 530, the operations asfollows can be executed without causing failure, for example.

That is, similarly to the medicine inspection device 10, it is possibleto provide a configuration of the medicine inspection device 300 whereina supply detection means 24 a and a reading device 72 are provided inthe upstream of conveyance path with respect to the inspection unit 14,and a dispense detection means 24 b is provided in the downstream ofconveyance path with respect to the inspection unit 14. Here, if normal,together with detecting a continuous body of sachets B by supplydetection means 24 a, by sending the continuous body of sachets B byexecuting the above-mentioned forward operation to move it only by apredetermined distance from the moment of recognizing by reading the barcode provided at the top section of the continuous body of sachets Bwith a reader device 72, it is possible to make a sachet b to beinspected to reach the inspection unit 310 and the position thereof canbe determined.

However, when introducing a continuous body of sachets B, if an operatormisses the timing of releasing a hand from the continuous body ofsachets B or the like, it's rare but the continuous body of sachets Bmay not travel in the conveyance path as expected, and there is apossibility of sachet b cannot be positioned accurately with respect tothe inspection unit 310. If such a problem is expected, it is desirableto operate by combination of forward and reverse operations, andintroduce a continuous body of sachets B in the following manner.

That is, when introducing a continuous body of sachets B into thedevice, by first operating the transportation means 12 in the forwarddirection, a continuous body of sachets B is drawn through a path toreach the installation location of dispense detection means 24 b via theinstallation location of the supply detection means 24 a and inspectionunit 310. With this, at the moment when the continuous body of sachets Bis detected by dispense detection means 24 b, the transportation means12 is operated in reverse direction, and the sachet b to be inspected isreached to the inspection unit 310. The positional relationship betweenthe dispense detection means 24 b and inspection unit 310 is determinedin advance, and cannot be changed. Therefore, by performing a reverseoperation to move the continuous body of sachets B in the oppositedirection only by a distance between dispense detection means 24 b andinspection unit 310, a sachet b can be accurately positioned withrespect to the inspection unit 310.

Also, if a continuous body of sachets B is introduced into the device asexplained above, even if a continuous body of sachets B is assumed to beshort, an upright-state elimination means 530 prevents a problem such asa continuous body of sachets B riding onto top of the upright-stateelimination means 530 during reverse operation.

<<Another Modification Example for Introduction Operation of aContinuous Body of Sachets>>

If the above-mentioned upright-state elimination means 530 orupright-state elimination means 700 is provided, a continuous body ofsachets B can be moved smoothly in forwards direction (forwardoperation) as well as in reverse direction (reverse operation).Therefore, when each sachet b of a continuous body of sachets B isinspected in the inspection unit 14, if the result of the inspection isdetermined to be different from the prescription, or if a potentialforeign object is identified to be present in sachet b, it is possibleto move the sachet b in the opposite direction up to the upright-stateelimination means 530, 700, and to reciprocate the continuous body ofsachets B within the range where the upright-state elimination means530, 700 contacts the surface of the sachet b.

As described above, by moving the sachet b to the upright-stateelimination means 530, 700 and reciprocating it in case the result ofinspection is abnormal, a medicine contained in sachet b can be surelyoverturned, and made into a state in which an accurate inspection ispossible. Thus, if the cause for abnormal inspection result is due tothe upright state of the medicine contained in sachet b, this cause canbe resolved.

As described above, by sending a continuous body of sachets B inopposite direction up to upright-state elimination means 530, 700 if theresult of the inspection differs from the prescription information, aninspection failure due to upright state of a medicine can be resolved,and the inspection accuracy can be improved. As described above, bysending a continuous body of sachets B in opposite direction up toupright-state elimination means 530, 700 only if the result of theinspection differs from the prescription information, an inspectionfailure due to upright state of a medicine can be resolved, and theinspection accuracy can be improved.

<<Conveyance Guide>>

In the medicine inspection devices 10, 300, a plurality of conveyanceguides 13 are aligned in the conveyance direction on the side of thetransportation means 12 for sending a continuous body of sachets B toinspection unit 310. As for the conveyance guides 13 shown in FIG. 5 andFIG. 16 etc., the guide roller 15 b is attached rotatably at the tip ofsupport arm 15 a, which is biased towards conveyance path. Theconveyance guide 13 can come in contact with the guide roller 15 b inthe section corresponding to the transverse seal part of a continuousbody of sachet that travels on the conveyance path, and apply pressingforce. Therefore, a continuous body of sachets B can be guided withoutneed to apply pressing force to the medicine contained in each sachet b.

Here, in case the transportation means 12 is operated in forward andreverse directions as described above when introducing theabove-mentioned continuous body of sachets B into the device, it ispossible that the continuous body of sachets B may climb on theconveyance guides 13. If there is such a concern, it is desirable that,instead of the conveyance guides 13 shown in FIG. 5 and FIG. 16, etc. aconveyance guide 550 as shown in FIG. 51 be installed as shown in FIG.47 through FIG. 49.

Specifically, the conveyance guide 550 is formed so as extend in theconveyance direction by the transportation means 12, and is providedwith a support arm 552 that can surface-contact the surface of thecontinuous body of sachets B passing over the conveyance path. Theconveyance guide 550 is installed at the side of the transportationmeans 12 so as to align with the support arm 552 without providing a gapfor the passage of a sachet. Further, at the center in the longitudinaldirection of the support arm 552, a guide roller 554 is attached.

By configuring the conveyance guide 550 as described above, irrespectiveof moving the continuous body of sachets B either in forward directionor reverse direction on the conveyance path, it is possible to preventthe continuous body of sachets B from climbing on the conveyance guide550. Furthermore, because the guide roller 554 pass over the lateralsealing part of the continuous body of sachets B, the passing of theguide roller 554 on the medicine contained in each sachet b can beprevented.

<<Edge Detection by Composite Image>>

Next, a modification example of the image inspection method implementedin the medicine inspection device 300 shown in the above-mentionedsecond embodiment will be described. As described above, in the medicineinspection device 300, it is possible to identify the quantity and typeof medicine packaged in a sachet b, and check whether they match theprescription information by following the flow shown in FIG. 26 or FIG.66. Here, when executing the image inspection process in step 1-4 orstep 6-6 of the flow shown in FIG. 26 or FIG. 66, a matching process isperformed on the image (basic image processed image) obtained byprocessing the basic image via the respective processes of step 1-1through step 1-3, or step 6-1 through step 6-5.

Here, when performing the matching process in step 1-4 or step 6-6, aprocess is executed wherein the outer contour that is thought to be theimage of the medicine is extracted from the basic image processed imageas an edge. When the color of a medicine included in the basic imageprocessed image is not same as the background color of the image, theouter contour of the medicine can be extracted easily and accurately.However, in case the color of a medicine is same as the backgroundcolor, extraction of the outer contour of the medicine is considered tobe extremely difficult. Therefore, when the extraction of the outercontour of the medicine is difficult because the color of a medicine issame as the background color or the like, a composite image edgeextraction process described below can be executed using a controldevice 330.

The composite image edge extraction process is executed by using abrightness map image created based on back unlit image and a saturationmap image, in addition to the basic image processed image obtained viathe respective processes in step 1-1 through step 1-3, or step 6-1through step 6-5 described above. A brightness map image is an imagerepresented by the brightness component constituting a back unlit image.Also, a saturation map image is an image represented by saturationcomponent constituting a back unlit image. In the composite image edgeextraction process, a process for extracting an edge present in acomposite image is executed using a composite image created byoverlapping a basic image processed image, a brightness map image, and asaturation map image. With this, it becomes possible to easily andaccurately extract the outer contour of a medicine that was difficult toextract with only a basic image processed image.

The composite image edge extraction process described above may beexecuted regardless of the difference or similarity between thebackground color and the color of a medicine, but it is preferable toexecute the process only in the case wherein the background color of abasic image processed image and the color of a medicine are of the samecolor. If the composite image edge extraction process is only performedin the case where the background color and the color of the medicine aresame, the decrease in the processing speed of matching process can beminimized.

<<Modification Example of Edge Detection by Composite Image>>

In order to enhance the processing accuracy when executing the matchingprocess for the image (basic image processed image) obtained byprocessing the basic image via each process of step 1-1 through step1-3, or step 6-1 through step 6-5, there may be cases where it ispreferable to detect the edges of medicine based on the composite imagethat was processed based on the basic image as described above and toperform the matching process rather than using the basic image processedimage alone. In addition, even regarding the composite image used foredge detection, it is desirable to use the best one considering such asthe color of the medicine to be inspected. The edge detection methodbased on this aspect is described below in detail with reference to theflowchart shown in FIG. 68.

In the control flow of FIG. 68, the region of inspection included in thebasic image is first extracted in the basic image processed imageacquisition process of the steps 7-1, and the process of acquiring basicimage processed image is executed. Specifically, a basic image processedimage is obtained, for example, by executing each of the processes ofstep 1-1 through step 1-3 of the control flow shown in FIG. 26, or step6-1 through step 6-5 of the control flow shown in FIG. 66.

If the acquisition of basic image processed image is finished in step7-1, the control flow will proceed to the inspection HSV resolutionimage acquisition process of step 7-2. In this process, the back unlitimage obtained by taking an image in a state where the backlight 314 isin an unlit state and the diffusion light emitting device 160 is in anilluminated state is subjected to HSV resolution. One of the back unlitH channel image, back unlit S channel image and back unlit V channelimage obtained is used as a HSV resolution image for inspection.

Here, in obtaining the HSV image for inspection, a predetermined one canbe selected regardless of condition among the back unlit H channelimage, back unlit S channel image and back unlit V channel imageregardless of condition, but it is desirable to differentiate a channelimage selected based on whether the background color of a sachet and thecolor of the medicine that is contained in the sachet b are of samecolor or not at the time of acquisition of basic image or back unlitimage. Specifically, in case the background color of sachet b and thecolor of the medicine accommodated in the sachet b are of same color, itis desirable to select the back unlit H channel image as a HSVresolution image for inspection. Moreover, in case the background colorof the sachet b and the color of the medicine that is contained in thesachet b are different, it is desirable to select the back unlit Schannel image as a HSV resolution image for inspection.

If the process of HSV resolution image acquisition for inspection ofstep 7-2 is completed as described above, the control flow proceeds tothe process of single channel image acquisition for inspection of step7-3. In this process, one among the back unlit R channel image, backunlit G channel image and back unlit B channel image obtained byRGB-resolving the back unlit image is acquired as a single channel imagefor inspection. Even regarding the selection method of a single channelimage for inspection, a pre-specified one can be selected regardless ofcondition as described in connection with the selection method of HSVresolution image for inspection, it is desirable to perform theselection as follows. That is, utilizing the fact that the position ofthe inspection area and area other than the inspection area have beendetermined in advance in the basic image processed image that wasacquired in step 7-1, among the back unlit R channel image, back unlit Gchannel image and back unlit B channel image, one having the largestcontrast between inspection area and area other than the inspection areais selected as the single channel image for inspection.

Once the acquisition of single channel image for inspection of step 7-3is completed as described above, the control flow will proceed tocomposite image edge extraction process of step 7-4. In this process, acomposite image is obtained by combining the basic image processed imageacquired in step 7-1, HSV resolution image for inspection acquired instep 7-2, and single channel image for inspection acquired in step 7-3as a three channel image.

When a composite image is obtained as described above, the control flowproceeds to the composite image edge extraction process of step 7-5, andan image processing is carried out for extracting edges included in thecomposite image. With this, the contour of a medicine inside a sachet bcan be identified.

As described above, if the contour of the medicine is identified byusing the composite image obtained by combining the basic imageprocessed image and HSV resolution image for inspection and singlechannel image for inspection as a three channel image, it is possible toadd a perspective of HSV color space and perspective of RGB color modelas a perspective for extracting the edge corresponding to the outer edgeof the medicine. With this, it becomes possible to further improve theidentification accuracy of the contour of a medicine, and to execute theinspection of the medicine quickly with high accuracy.

In the control flow explained above, a relation between the color of themedicine and background color is considered when selecting the HSVresolution image for inspection, and whether the medicine is of samecolor as the background color is taken into account. That is, if thecolor of a medicine is same as the background color, the back unlit Hchannel image is chosen as the HSV resolution image for inspection bytaking into consideration that there is a high possibility of strongmanifestation of a difference in the color phase between medicine andbackground. If a medicine is of a color that is different from thebackground color, the back unlit S channel image is chosen as a HSVresolution image for inspection by taking into consideration that thereis a high possibility of strong manifestation of a difference insaturation. By this, the identification accuracy of the contour of amedicine and inspection accuracy of the medicine can be improved.

Further, in the control flow described above, because one having thelargest contrast between inspection area and area other than theinspection area is selected among the back unlit R channel image, backunlit G channel image and back unlit B channel image, accuracy inextracting the edge corresponding to the outer edge of a medicine isimproved. With this, it is possible to further improve theidentification accuracy of the contour of a medicine and inspectionaccuracy of the medicine.

<<Medicine Database for Inspection and Contour Image Database of DividedMedicine>>

Both the medicine inspection devices 10 and 300 described above identifythe type and quantity of a medicine and perform the inspection by imageinspection. Here, when performing image inspection, as shown in FIG. 52,as a part of the medicine master 370, a database (inspection medicinedatabase 560) will be required in which information such as theappearance image, size, type, color etc., of a medicine have been storedas master data for matching. In other words, image inspection can beperformed by the medicine inspection devices 10 and 300 for a medicinewhose master data has been registered in the inspection medicinedatabase 560. Further, though the medicine packaged in sachet b may be atablet that has been divided into two or more parts (divided medicine),if information such as contour image etc., of the divided medicine isregistered in the inspection medicine database 560, precise inspectionwith the medicine inspection devices 10 and 300 will be possible.

Here, when registering the contour image of a divided medicine in theinspection medicine database 560, actual photographs of divided medicinecan be used. However, the types of medicines that can be registered inthe inspection medicine database 560 are enormous and it is an extremelycomplicated task to separately photograph one by one and register them.Therefore, it is desirable to register the contour image of undividedmedicine (whole tablet master contour image) in the inspection medicinedatabase 560, and to generate contour images of the divided medicine(divided tablet master contour image) by image processing whole tabletmaster contour image, and to register them in the inspection medicinedatabase 560.

As a means of creating a divided tablet master contour image from awhole tablet master contour image, although various methods can be used,the following means can be used, for example. That is, as shown in FIG.53A, by dividing the whole tablet master contour image at a boundary ofa dividing line DL passing through the center of the medicine regioncorresponding to the medicine, a divided tablet master contour image forthe divided medicine can be obtained.

Further, when a medicine is actually divided, it is possible that themedicine may get split in a position slightly deviating from the centerof the medicine. In such a case, the matching accuracy of the dividedmedicine may decrease because of the divided tablet master contour imageobtained by dividing the whole tablet master contour image at thedividing line DL. Therefore, when creating a divided tablet mastercontour image by image processing, as shown in FIG. 53A, it is desirablethat in addition to an image obtained by dividing the whole tabletmaster contour image with the DL line as the boundary, a quasi-dividingline SL is assumed at a position away by a predetermined distance fromthe dividing line D, and an image obtained by cutting out the wholetablet master contour image with this quasi-dividing line SL as aboundary is added as one of the divided tablet master contour images tothe inspection medicine database 560.

It is further desirable to set multiple quasi-dividing lines SL, and toprepare several types of divided tablet master contour images.Specifically, in the example shown in FIG. 53A, it is desirable to setquasi-dividing lines SL1 and SL2 that are away from the dividing line DLby a distance d in left and right directions respectively, andquasi-dividing lines SL3 and SL4 that are away from the dividing line DLby a distance 2d in left and right directions respectively, and imagesobtained by dividing the whole tablet master contour image at thesequasi-dividing lines SL1 to SL4 (see FIG. 53B) are added as dividedtablet master contour images to the inspection medicine database 560.More specifically, it is desirable to perform the aforementioned imageprocessing to acquire divided tablet master contour images by assumingthe quasi-dividing lines SL1 to SL4 at locations away from the dividingline DL by predetermined pixels in left and right directions. By doingso, even for a case wherein a medicine is broken at a position slightlyaway from the center of the medicine, it becomes possible to carry outimage inspection on a divided medicine with excellent accuracy.

Here, when creating divided tablet master contour images for a dividedmedicine by specifying a dividing line DL as described above, it may bedifficult, depending on the shape of the medicine, to specify thedividing line DL that can divide a medicine into exactly two halves.Specifically, in case of medicines having shapes as shown in FIG. 53 andFIG. 54, it is normal to specify a dividing line DL as shown in FIG. 53Aand FIG. 54B, but a dividing line DL may be specified as shown in FIG.54A. Therefore, it is desirable to specify a dividing line DL byfollowing the procedure shown below so that an appropriate dividing lineDL can be specified for medicines of any shape.

Namely, as shown in FIG. 54, a rectangular guide G for setting divisionline that is in contact with the medicine region externally is assumedin the contour image for inspection. Thereupon, as shown in FIGS. 54Aand 54C, a division candidate line CL that passes through the center ofthe guide G for setting division line and that forms a lineperpendicular to the length side of a rectangle forming a vertical linesetting guide is specified. The medicine region existing on one side ofthis division candidate line CL is defined as CA, while the medicineregion existing on the other side is defined as CB. Then, as shown inFIGS. 54B and 54D, the size of a region that is not overlapped(non-overlapping region CC) when the medicine region CA is inverted onthe medicine region CB with the division candidate line CL as boundary(for example, when CA and CB are overlapped) is derived. Such a processof deriving a non-overlapping region CC by rotating the rectangularregion constituting the guide G for setting division line by variouspredetermined angles is performed for the entire perimeter of themedicine region. As a result, the division candidate line CL when thenon-overlapping region CC is smallest is defined as dividing line DL.With this, appropriate dividing lines DL can be specified for medicinesof any shape.

As for a divided tablet master contour image for the inspection medicinedatabase 560 obtained as described above, a contour image of medicinecan also be registered in the contour image database 372 for reference.With this, a contour image of a divided medicine can also be displayedto an operator.

Next, the work flow for registering a divided tablet master contourimage into an inspection medicine database 560 is illustrated. Here,regarding the example described below, it can be also used forregistration of colors of medicines in order to accommodate edgedetection by the composite image described above. Therefore, when themedicine inspection devices 10 and 300 do not accommodate edge detectionby composite images, the registration of colors of medicines can beomitted.

When registering a divided tablet master contour image in the inspectionmedicine database 560, a window as shown in FIG. 55A is displayed on theoperation screen of the operator. In this window, upon selecting thebutton (displayed as ‘Soft Capsule’ in the illustrated example) locatednext to “type”, a window as shown in FIG. 55B is displayed, and byselecting a type of the medicine, input becomes possible. In thisexample, a type of medicine can be selected from four types that arecapsule, soft capsule, naked tablet, and sugar-coated tablet. If nakedtablet is selected, for example, as shown in FIG. 56, a displaycorresponding to the type selected is shown (in this example, ‘SoftCapsule’) on the button located next to “type”.

Also, in the window shown in FIG. 55A, if the button located next to‘Medicine Detection’ is selected, a window shown in FIG. 56 isdisplayed. In the window of FIG. 56, it is possible to select whether toperform medicine detection by the detection method for carrying out edgedetection with composite image (mentioned as ‘Special’ in theillustrated example), or by normal detection method (mentioned as“Normal” in the illustrated example). If “Special” button is selected inthis window, for example, it will return to the window shown in FIG.55A, and the selection is appended to the button.

In the window shown in FIG. 55A, if the button located in switch columnat top right is selected, a window as shown in FIG. 57A is displayed,and it is possible to choose whether the medicine to be registered inthe inspection medicine database 560 is a divided medicine or not. Here,by selecting the button of ½ tablet, the image corresponding tohalf-tablet as shown in FIG. 57B will be registered as a divided tabletmaster contour image.

<<Modified Example of a Construction Method of Inspection MedicineDatabase and Contour Image Database of Divided Medicine>>

The method of constructing inspection medicine database and contourimage database of divided medicine is not limited to the above-mentionedmethod, and other methods may also be used. Specifically, in many of themedications prescribed in a divided state, for the purpose of easy splitor the purpose of split position index, a groove (drug division groove)is formed in the surface of the medicine. Therefore, when a medicinedivision groove is present in a medicine included in the whole tabletmaster contour image, by setting the dividing line DL having thismedicine division groove as an indicator, it is expected that a dividedtablet master contour image for constructing the inspection medicinedatabase and contour image database of divided medicine can be acquiredeasily and with high accuracy. In light of such finding, the method ofacquiring a divided tablet master contour image is described accordingto the control flow shown in FIG. 72.

In the control flow shown in FIG. 72, first, in the medicine divisiongroove identification process of step 10-1, the whole tablet mastercontour image is subjected to image analysis, and the medicine divisiongroove of the medicine is searched. Subsequently, in step 10-2, whethera medicine division groove was detected or not is verified. Here, incase the medicine division groove was not detected, the dividing line DLcannot be set based on the medicine division groove according to thiscontrol flow, and therefore, the control flow ends. In this case, adivided tablet master contour image is acquired by a method for settingthe dividing line DL without having the medicine division groove as anindication as described above.

On the other hand, in case the detection of a medicine division groovewas confirmed in step 10-2, the control flow proceeds to division linedetermination process of step 10-3. In the division line determinationprocess, a dividing line DL passing through the medicine division grooveimaged in the whole tablet master contour image (shown by the symbol AMin FIG. 72) is determined.

When a dividing line DL is set in step 10-3, the control flow proceedsto an angle adjustment process of step 10-4. In the angle adjustmentprocess, together with fixing the dividing line DL determined in thedivision line setting process of step 10-3, a process is executed inwhich, with the dividing line DL as reference, the whole tablet mastercontour image AM is rotated around the center of gravity of the medicineat each predetermined angle in positive and negative directions, andchecking whether the medicine regions existing on either sides of thedividing line DL are symmetrical or not. When the medicine regions onboth sides of the dividing line DL become symmetrical, the rotation ofthe whole tablet master contour image AM is stopped at that location.This completes the angle adjustment of the whole tablet master contourimage AM.

Once the angle adjustment of the whole tablet master contour image AM iscompleted as described above, the control flow moves to imageacquisition process of step 10-5. In the image acquisition process, thewhole tablet master contour image in which an angle thereof has beenadjusted in step 10-4 is divided with reference to the dividing line DLset in step 10-3 to obtain a divided tablet master contour image. Byusing such a method, a divided tablet master contour image of highaccuracy can be acquired.

<<Side Illumination>>

When taking images configuring a contour image database 372, it isdesirable to take an image by irradiating light with as much brightnessas possible and from a suitable direction in order to obtain a vividimage. Therefore, as shown in FIG. 47, it is possible to have aconfiguration of providing side illuminations 570, 572 for irradiatingthe inspection unit 310 in locations adjacent to upstream and downstreamof the inspection unit 310.

Any side illumination 570, 572 may be used as long as it is possible toacquire a vivid image, and a bar-shaped lighting as shown in FIG. 47,etc. can be used. Also, conventionally known light bulbs, fluorescentlights, LEDs or the like may be used as a light source of sideilluminations 570, 572. In this embodiment, LED is built-in as a lightsource of the side illuminations 570, 572, and is installed such thattheir optical axis is directed towards the inspection unit 310 andoriented towards horizontal direction or upward of horizontal direction.By installing in this manner, a vivid image for configuring contourimage database 372 etc. can be obtained.

<<Image Drawings>>

In the medicine inspection device 10, 300, although an image displayedto the operator in each stage of operation can be suitably modified, itis also possible to use something like those shown in FIG. 58 throughFIG. 64, for example. Specifically, when showing the result ofinspection by displaying the back unlit images of each sachet b in athumbnail format, apart from using a display format shown in FIG. 29A, anumber in the sequence of inspection for an inspected sachet b may alsobe included adjacent to a thumbnail image as shown in FIGS. 58A and 58B.Thus, identification of a sachet b and distinguishability of inspectionresult is further improved. Also, the distinguishability can be furtherimproved by changing the color etc. of the border line around thumbnailimages according to the determined result.

Also, as shown in FIGS. 58A and 58B, the result of inspection isdisplayed at top right for quantity and external appearance separately.Specifically, in the column displaying ‘Quantity’, in addition todisplaying the inspection results for quantity as either ‘OK’ or ‘NG’,the package count is also displayed. Also, in the ‘Collation’ displaycolumn, in addition to displaying the inspection result based onexternal appearance as either ‘OK’ or ‘NG’, the package count is alsodisplayed.

When displaying a list of collation results in the medicine inspectiondevice 10, 300, it may be displayed by an image drawing as shown in FIG.59, for example. When the result is display by such an image drawing, ifthe color of display column is varied based on the OK/NG of the resultof collation, the distinguishability can be further improved.

Instead of image drawings shown in FIG. 30 through FIG. 32, it is alsopossible to use image drawings shown in FIG. 60 through FIG. 64.Specifically, in image drawings shown in FIG. 60 through FIG. 64, all ofthe followings are included in a single image drawing: (1) attributedisplay part 580, (2) package count display part 582, (3) image displaypart 584, (4) details display part 586, (5) dosing time display part588, (6) inference display part 590, and (7) button display part 592.

The attribute display part 580 is a region for displaying attributeinformation such as patient name, ID no., and dosing time of themedicine contained in an inspected sachet b. The package count displaypart 582 is a region for displaying the quantity of sachets b of acontinuous body of sachets B, and the number that the displayed sachet bwas inspected in the form of a fraction or the like. The image displaypart 584 is a region for displaying the image of an inspected sachet b.In the image display part 584, an image can be displayed by includingthe outline of the medicine. The show/hide of the outline can beswitched by pressing the button provided in the button display part 592.Further, as shown in FIG. 60A, by selecting medicine etc. listed in thedetails display part 586, which is described later in detail, it becomesa state wherein the outline corresponding to that medicine etc. isidentifiable from others (active state). In the example of FIG. 60A, adisplay is shown wherein the outline of a selected medicine is displayedby a dotted line, and as if the dotted line is revolving in thecircumferential direction of the medicine, but it is also possible tomake it to an active state by blinking the outline, for example.

The details display part 586 lists the prescription data and inspectionresult. In the details display part 586, image for checking, medicinename, prescription quantity, and inspection result for each medicinewill be displayed side-by-side in a line. Although any appropriatemethod of displaying inspection results can be adopted, if a medicine ispackaged as per the prescription, an ‘OK’ will be displayed in thecolumn corresponding to the medicine in the examples of FIG. 60 throughFIG. 64 (see FIG. 60B). Also, if there are similar medicines, “similarexist” will display as a reminder (see FIG. 61A). Further, if a medicineis not packaged in accordance with the prescription data, the reason forthe result will also be mentioned.

Specifically, in FIG. 61B, ‘insufficient’ is displayed since thequantity of the medicine is insufficient. In the example shown in FIG.62A, ‘Excess’ is displayed since the quantity of the medicine largerthan the prescribed quantity is packaged. In the example shown in FIG.60B, because a foreign object is coexisting in sachet b, this matter isdisplayed. Regarding a display notifying the foreign objectcontamination, though it is possible to display in continuation with themedicine list display or coexist within the medicine list, it isdesirable to display in a location away from the medicine list such asin the bottommost column etc. as shown in FIG. 60B in order to improvethe distinguishability. In the example shown in FIG. 60B, an objectidentified as a foreign object in the image of image display part 584 isenclosed by a circular mark and displayed. In the example shown in FIG.62B, because a medicine with a different color exists, it is displayedas ‘Color mismatch’.

In the example shown in FIG. 63, since the medicine quantity is lessthan the prescribed quantity, it is displayed as ‘Insufficient’.Further, since an unknown medicine exists, this fact is displayedsimilarly to foreign object contamination of FIG. 60B. An object thatwas identified as an unknown medicine in the image of image display part584 is enclosed by a circular mark. It is desirable to make the enclosedline prominent by changing the color at certain time intervals, or byblinking etc. In the examples shown in FIG. 60 through FIG. 64, it isdesirable to change the color of the outline of the medicine in theimage displayed in the image display part 584 according to the result ofinspection.

When displaying the master information for each medicine, apart fromdisplaying as in FIG. 36C, it is also possible to display it as shown inFIG. 64A. When registering master information, as shown in FIG. 64B, inaddition to displaying textual information such as medicine product nameand attributes, it is desirable to display front, rear and side surfaceimages etc. of the medicine.

It is possible to have a configuration in which, by providing anoperation condition setting screen for medicine inspection devices 10,300 as shown in FIG. 74A, various settings for the operation method canbe made in the operation screen. Specifically, as for inspection method,it is possible to have a configuration wherein buttons 800, 802 isprovided to enable selecting whether the respective sachets b of acontinuous body of sachets B is collectively inspected, or each sachetis inspected one by one. As a criteria for judging the inspectionresult, it is possible to provide a quantity button 804 to set theoperation so as to check whether or not the quantity of the medicine ismatching the prescription information and not to check the type of amedicine, a collate button 806 for setting the operation to performinspection by collating both the quantity and type of medicine with theprescription information, and a visual button 808 that enables visualinspection by health care providers such as pharmacists and doctors isalso possible.

It is possible to suitably vary the display method of inspection resultsusing the medicine inspection device 10, 300, but one shown in FIG. 74Bcan be used, for example. Specifically, regarding the inspection resultsobtained by the medicine inspection device 10, 300, a different displayformat can be shown for when the packaged medicine is a completemismatch with the prescription, when an item resembling the prescribedmedicine is contained, and when the medicine is a complete match withthe prescription. In the example shown in FIG. 74B, in case of acomplete mismatch, the thumbnail image depicting the sachet b isenclosed by a red border line, and by a yellow border line in case asimilar medicine is contained, and by a blue border line in case of acomplete match. When using the results of visual inspection by healthcare providers such as pharmacists and doctors, such results aredisplayed with symbols such as ◯ or X etc., and are displayed by adisplay method that is different from the display of inspection resultsby the medicine inspection devices 10, 300.

<<Data Linkage with Medicine Packaging Device>>

It is desirable to execute the image inspection based on theprescription data acquired from a medicine packaging device 100 byconnecting the above-mentioned medicine inspection devices 10, 300 to amedicine packaging device 100 such that data communication is possible.With this, a series of operations starting from packaging operation ofmedicine till inspection operation can be performed without a hitch,speedily and accurately.

<<Journal>>

In the medicine inspection devices 10, 300, it is desirable to be ableto output printing (Journal) showing the inspection results. Althoughthe output format of the journal can be of any format, it is possible toprint as shown in FIG. 65, for example. Specifically, if the inspectionresult is good, it is possible to print as shown in FIG. 65A. If thereis a sachet b for which the inspection result has a problem, it ispreferable to print so as to identify the sachet b having a problematicinspection result, and to print the reason for the problem as shown inFIG. 65B. If necessary, it is also possible to include an identificationindicator such as bar code as shown in FIG. 65C.

<<Modified Example of Medicine Inspection Process>>

In the above-mentioned embodiment, an example of carrying out aninspection process while acquiring various types of images as shown inFIG. 27 as per the control flow shown in FIG. 26, but the presentinvention is not limited to this. Specifically, it is possible to carryout the inspection process while acquiring various types of images asshown in FIG. 67 as per the control flow shown in FIG. 66. Below, amethod of executing a medicine inspection process according to thismodification example will be described in detail with reference to thedrawings. Here, in the following description, duplicate descriptionswill be omitted for sections to perform identical processes as thecontrol flow shown in FIG. 26 or the like in the above embodiment.

In the control flow shown in FIG. 66, first, in the basic imageacquisition process of step 6-1, a basic image for medicine inspectionis acquired based on the back lit image photographed with the packagingpaper illuminated from back by the backlight 314 (see FIG. 67A). Then,in the gray scale image acquisition process of step 6-2, a gray scaleimage is acquired by gray-scaling the basic image acquired in step 6-1(see FIG. 67B).

Once the gray scale image acquisition is completed in step 6-2, thecontrol flow proceeds to the gray morphology treatment process of step6-3. In this process, a top hat treatment, bottom-hat process, and imagejoining process, which will be described later in detail, are carriedout in order. That is, in the gray morphological process, first, the tophat treatment is executed in step 6-3 a. In the execution of the top hatprocess, the basic image acquired in step 6-1 is subjected to RGBresolution. In this manner, an R channel image (basic R channel image)as shown in FIG. 67C is obtained.

In step 6-3 a, the basic R channel image is subjected to top hattreatment. By this, a top hat image as shown in FIG. 67D is obtained. Atop hat image shown in FIG. 67D is an image that selectively shows, inthe gray-scale image, a dot-patterned section corresponding to thetransmitted light passing through the print area on sachet b.

In the bottom-hat process of step 6-3 b, the basic R channel image issubjected to bottom hat process. By this, a bottom hat image as shown inFIG. 67E is obtained. A bottom hat image shown in FIG. 67E is an imagein which, among the print section on sachet b included in the gray scaleimage, a region excluding the dot-patterned section corresponding to thetransmitted light described above is selectively shown.

Once the top hat image and bottom hat image are acquired as describedabove, the control flow proceeds to the image joining process of step6-3 c. In this process, by combining the top hat image and bottom hatimage, an exclusion area identification image as shown in FIG. 67F isobtained. This exclusion area identification image is a combination ofthe dot-patterned area corresponding to transmitted light passed throughprint section of the sachet b and a region excluding the dot-patternedsection. Therefore, the exclusion area identification image is an imageshowing the print area on sachet b.

Once the exclusion area identification image is acquired as describedabove, the control flow proceeds to inspection area determinationprocess of step 6-4. In this process, by obtaining the differencebetween the gray scale image obtained in step 6-2, and the exclusionarea identification image obtained in step 6-3, the region forinspection is identified. That is, in step 6-4, a process of excludingthe printing area on sachet b from the entire region of the gray scaleimage is performed. By this, it is possible to form a filter foridentifying the area to be inspected (inspection area) in the regionsincluded in the gray scale image.

Once the identification of the inspection area is completed as describedabove, the control flow proceeds to inspection image acquisition processof step 6-6. This is a process executed for the purpose similar to thatof step 1-3 shown in FIG. 26 described above. That is, from a back unlitimage wherein the region same as the back lit image was photographedwith the backlight 314 switched off, an image of the area correspondingto the inspection area determined in step 6-5 is acquired as the imagefor inspection. In other words, the filter for inspection areaidentification obtained in step 6-5 is applied to the back unlit imageto narrow down the area for inspection and to exclude the print area onthe sachet b.

Once the image for inspection is acquired in step 6-5, the control flowproceeds to image inspection process of step 6-6. In this process, basedon the image for inspection acquired in step 6-5, an inspection processis executed for detecting either the medicine quantity or type or both.The inspection process in step 6-5 is carried out in the similar manneras in step 1-4 of the control flow shown in FIG. 26 described above.

If the image for inspection is acquired as described above, it ispossible to separate a region containing text or symbols etc. printed onsachet b from a region containing medicine with even higher accuracy,and to determine the image for inspection. With this, the speed ofinspection process can be improved while further improving the medicineinspection accuracy.

<<Detecting Introduction Failure of Continuous Body of Sachets>>

As described above, in the medicine inspection devices 10, 300, a stripof continuous body of sachets B in which each dose is packaged in asachet b is supplied sequentially to inspection units 14, 310, andinspected. Here, if a continuous body of sachets B is a long body,introduction failure is likely to occur due to distortion in theintroduction units 10 b, 304. Therefore, it is desirable that themedicine inspection devices 10, 300 have a configuration in whichintroduction failures at the introduction units 10 b, 304 can bedetected. To deal with such problems, the following configuration can beadopted, for example. In the following explanation, of the introductionunits 10 b, 304, explanation is made using 304 as an example.

As shown in FIG. 42 and FIG. 43, the introduction unit 304 is comprisedof a horizontal surface 304 a for facilitating, at the time of feeding acontinuous body of sachets B into casing 302, to dispose the continuousbody of sachets B in a flat state and help pass through. On both sidesof the horizontal surface 304 a, guide pieces 306 and 306 are providedso as to guide a continuous body of sachets B without tilting. Further,in a position that is on both sides of the horizontal surface 304 a andthat is adjacent to the guide pieces 306, 306, that is, on both sides ofthe horizontal surface 304 a based on the passage direction of thecontinuous body of sachets, sachet detecting sensors 304 b and 304 b fordetecting a continuous body of sachets B passing on the horizontalsurface 304 a are provided. The sachet detecting sensors 304 b and 304 bare connected to a control device 330 to facilitate informationcommunication.

The control device 330 functions as an introduction failure determiningmeans for determining an introduction failure of a continuous body ofsachets B at the introduction unit 304. Specifically, the gap betweenthe guide pieces 306 and 306 in the introduction unit 304 is made to beof a size similar to the width of the continuous body of sachets B(sachet b) for preventing a tilted introduction etc. of the continuousbody of sachets B (sachet b). Therefore, when a continuous body ofsachets B (sachet b) is fed without distortion, both of the sachetdetecting sensors 304 b and 304 b installed near the guide pieces 306and 306 will detect the continuous body of sachets B (sachet b). On theother hand, if a continuous body of sachets B (sachet b) is distorted,only one of the two sachet detecting sensors 304 b and 304 b will detectthe continuous body of sachets B (sachet b), and there will be nodetection by the other sensor. Therefore, with a condition that acontinuous body of sachets B is detected by only one of the two sachetdetecting sensors 304 b, 304 b provided on both sides, the controldevice 330 determines that a continuous body of sachets is distorted andhaving an introduction failure in the introduction unit, and notifies.

If the distortion of a continuous body of sachets B (sachet b) can bedetected as described above, an inspection failure accompanying theintroduction failure of a continuous body of sachets B (sachet b) can beprevented. In addition, damage etc. due to introduction of a continuousbody of sachets B (sachet b) in distorted state can be prevented.

<<Shape of Introduction Unit>>

As shown in FIG. 42 and FIG. 43, the introduction unit 304 has a shapewherein the end section of a plate that forms the bottom surface 308 ofthe introduction unit 304 is bent in the form of an arc in the lowerdirection in order to prevent a continuous body of sachets B fromgetting stuck, but the present invention is not limited to this, and aconfiguration for example shown in FIG. 73 is also possible. That is,the end section of a plate that forms the bottom surface 308 of theintroduction unit 304 is bent to form a drooping part 304 c extendingroughly vertically downward. A bulging part 304 d that is bulging on thesurface (the side where a continuous body of sachets B passes) isprovided in the drooping part 304 c. Although it is possible to form thebulging part 304 d by further looping back the end part of the droopingpart 304 c, in this embodiment, the bulging part 304 d is formed byfixing a separately fabricated member of semicircular cross-section inthe width direction of the introduction unit 304.

When such a bulging part 304 d as described above is provided, acontinuous body of sachets B will contact the bulging part 304 d whenflowing along a plate forming the bottom plate 308, and the medicinecontained in each sachet b is subjected to a light vibration. This couldhelp getting rid of an upright state of medicine if the medicine waspackaged in an upright state in sachet b.

<<Sampling Inspection Mode>>

In the above-mentioned medicine inspection devices 10 and 300, allsachets b of a continuous body of sachets B introduced for inspectionare inspected, however, the present invention is not limited to this,and it is also possible operate in a sampling inspection mode bysampling a part, and display in a state where the inspection results canbe visually checked. As for the method of implementing samplinginspection mode, though it is possible to use any suitable method, it isalso possible to use the one described below, for example.

Specifically, in the example shown in FIG. 76, an operation by samplinginspection mode becomes possible by pressing the ‘Sampling display’button. In this example, when a continuous body of sachets B includesafter-breakfast dose, after-lunch dose and after-dinner dose that areformed continuously, among multiple sachets b corresponding to eachdosage time, the inspection result is sampled for the first and lastsachets and displayed. In the example shown in FIG. 76, the inspectionresults for after-breakfast dose, after-lunch dose and after-dinner doseare vertically classified according to the dosage time and displayed. Inthis example, the inspection results for after-breakfast dose are shownin the upper row, after-lunch dose in the middle row and after-dinnerdose in the bottom row.

In the sampling inspection mode, in addition to the first sachet andlast sachet of each dosage period, the result of inspection where theinspection result does not match the prescription data, or aquestionable inspection result where there is a possibility of presenceof a similar medicine are also displayed. For each case of a case wherethe inspection results are consistent with the prescription data, a casewhere the inspection results are inconsistent, and a case where cautionis required because of a possibility of existence of an analogousmedicine, display is done by different method. In the example shown inFIG. 76, the color of the border surrounding a thumbnail showing eachsachet b is changed in accordance with the inspection result.Specifically, the result is displayed by blue border if the inspectionresult is consistent with the prescription data, by red border ifinconsistent, and by yellow border if caution is required. As examplesof an inspection result requiring caution can include a case where ananalogous medicine is present, or medicines causing high risk to humans,or medicine in which packaging operation includes manual operation bypharmacists, etc.

In the example shown in FIG. 76, a result that a pharmacist or the likevisually checked and confirmed whether the inspection result is correctcan be displayed. Specifically, in the example shown in FIG. 76, uponpressing the ‘Remaining lot OK’ button, it will be possible to reflect ajudgment by pharmacists or the like that all of the inspection result iserror-free. Further, by pressing ‘After breakfast’ button, ‘After lunch’button, or ‘After dinner’ button, it is possible to reflect a judgmentby pharmacists or the like that there is no error with regard to thesachet b of after-breakfast dose, sachet b of after-lunch dose, orsachet b of after-dinner dose. In addition, in the example of FIG. 76,by pressing the ‘Visual inspection not yet’ button, only the thumbnailsof sachets b that have not been subjected to visual inspection can bedisplayed.

Moreover, when pressed a thumbnail that corresponds to each sachet bshown in FIG. 76C, the detailed information for this sachet b isdisplayed as shown in FIG. 76. In this display screen, by pressing thebutton ‘Visual inspection OK’ button, or ‘Visual inspection NG’, itbecomes possible to set the confirmation result by visual inspection bya pharmacist or the like.

By facilitating an operation as per the above-mentioned samplinginspection mode, it becomes possible to address a demand for selectivelychecking, among the inspection results, only an optional item. Withthis, the operation of checking inspection result by a doctor orpharmacist can be further simplified.

Moreover, when the thumbnail corresponding to a sachet b for whichinspection is to be carried out is pressed (selected) in a state shownin FIG. 76A and the detailed information as in FIG. 76C is displayed,after setting the confirmation result of visual inspection by such as apharmacist by pressing the ‘Visual inspection OK’ button, or ‘Visualinspection NG’, the subsequent operations can be suitably decided. Thatis, after setting the confirmation result of visual inspection in thestate of FIG. 76C, the display may return to the thumbnail view of FIG.76A or sequentially switch to images showing the detailed informationfor other sachets b that were selected for sampling display. As in thelatter case, by making it possible to sequentially switch displays ofthe detailed information for other sachets b that were selected forsampling display, the inspection operation by visual inspection can beeasier and faster.

Further, when there is an inspection result requiring caution such aswhen there is a medicine of high risk to human body (hereinafter alsoreferred to as ‘high risk medicine’), or when there is a medicinewherein the packaging of the medicine is also done by manual operationby a pharmacist or the like (hereafter also referred to as ‘manuallydistributed medicine’) etc. in the group of prescribed medicines or inthe medicine group judged to be analogous by the result of inspection,it is desirable to display alerts in various places of the displayscreen of FIG. 76C. Specifically, regarding the names of high riskmedicines, it is desirable to make the display format distinct bydisplaying the medicine name in a color different from normal (e.g. redcolor) or the like. Further, also regarding the judgment result of ahigh risk medicine, it is desirable that the display format be distinctby displaying the medicine name in a color different from normal.Further, based on the result of inspection, if a medicine of high riskis included in the group of medicines judged to be analogous, it isdesirable to clearly display the fact that a high risk medicine existsamong the candidates of analogous medicines by displaying the judgmentresult by a color that is different from normal (e.g. red color), etc.,for example. As the symbol ‘D’ was assigned to a manually distributedmedicine in FIG. 76C, for example, it is desirable to indicate that itis a manually distributed medicine by symbols etc., so that it can bedistinguished from others.

<<Display of Visual Inspection Result>>

The medicine inspection devices 10 and 300 may have a configuration inwhich, in addition to the inspection by the said devices, visualinspection by a doctor or a pharmacist is also possible. If such aconfiguration is adopted, by displaying an interface as shown in FIGS.77A and 77B, for example, the ability to discern inspection results byvisual inspection can be improved. Specifically, as shown in FIGS. 77Aand 77B, an inspection result by visual inspection can be displayed byusing a symbol such as ‘◯’ mark or ‘X’ mark for the thumbnail providedfor each sachet b so that the result is intuitively distinguishable.Also, it is possible to display the inspection result by visualinspection for an entire continuous body of sachets B comprised of acollection of sachets b in a predetermined format. Specifically, ifthere is a sachet b for which the inspection result by visual inspectionhas a problem, the indication that the inspection result for an entirecontinuous body of sachets B has a problem can be displayed in thedisplay column of inspection result provided at top right in FIG. 77A(in the example illustrated, displayed as ‘Visual inspection NG’).Likewise, if the inspection result by visual inspection for an entirecontinuous body of sachets B is good, the indication that the inspectionresult for an entire continuous body of sachets B is good can bedisplayed as in FIG. 77B (in the example illustrated, displayed as‘Visual inspection OK’). In this way, it becomes possible to distinguishthe result of visual inspection at a glance, and to further improve theuser-friendliness.

The present invention is not limited to the embodiments illustrated asfirst embodiment and second embodiment, and various modifications ofeach embodiment described above, and those skilled in the art may easilyunderstand that other modifications may be also obtained from theteaching and spirit within the scope of the claims.

The invention claimed is:
 1. A medicine inspection device, comprising:an inspection unit on which a medicine for inspection is disposed; avibrator to impart vibration to the medicine disposed on the inspectionunit; a shooting means capable of photographing the medicine disposed onthe inspection unit; a medicine information detector capable ofdetecting at least either of a quantity or type of the medicine based onan image obtained by the shooting means; and a distribution detectorconfigured to detect a distribution of the medicine on the inspectionunit based on the image obtained by the shooting means, wherein thevibrator is configured to operate based on a result of detection by thedistribution detector.
 2. The medicine inspection device according toclaim 1, wherein the medicine for inspection is supplied in wrappedstate in which each of the medicine is wrapped in a translucentpackaging paper for each dose.
 3. The medicine inspection deviceaccording to claim 2, wherein the vibrator is configured to impartvibration in preference to the inspection area containing more medicinesthan other areas.
 4. The medicine inspection device according to claim2, wherein the vibrator is configured to impart vibration to theinspection area containing largest number of medicines and not to impartvibration to other inspection areas.
 5. The medicine inspection deviceaccording to claim 2, wherein the vibrator comprises leaf springs and iscapable of generating vibration by elastic force of the leaf springs,and each of the leaf springs are provided for each of the inspectionareas, and wherein the leaf spring comprises a fixed part at one endfixed to another member and a free end at another end, the vibratorcomprises a shock imparting means to impart a shock to the free end ofthe leaf spring, and the fixed part is provided in a position departedfrom the inspection area.
 6. The medicine inspection device according toclaim 2, further comprising a diffusion light emitting device capable ofgenerating diffusion light and being provided above the inspection unit.7. The medicine inspection device according to claim 2, furthercomprising: a prescription information acquisition means for acquiringat least one of information regarding a prescribed quantity based on aprescription regarding a medicine for inspection or a prescribedmedicine type based on the prescription; and a collation means forcollating the prescription information with detected informationacquired by the medicine information detector.
 8. The medicineinspection device according to claim 1, further comprising: a vibrationcontroller configured to determine a necessity for generating vibrationbased on a distribution of medicines in the inspection unit detected bythe distribution detector, wherein when the vibration controllerdetermines that the vibration is necessary, the medicine inspectiondevice detects at least either of a quantity or type of the medicinebased on an image obtained by the shooting means after the vibratorimparts vibration, and when the vibration controller determines that thevibration is not necessary, the medicine inspection device detects atleast either of a quantity or type of the medicine based on an imageobtained by the shooting means without imparting vibration.
 9. Themedicine inspection device according to claim 1, wherein medicines aresupplied as a continuous array of sachets formed by packaging one doseof the medicine per sachet in a packaging paper and aligning the sachetsin form of a strip, and each sachet is able to be inspected one by one,the medicine inspection device further comprising: a prescriptioninformation acquisition means capable of capturing the prescriptioninformation based on an information medium if an information medium hasbeen provided to the continuous array of sachets to capture at least oneof information regarding the prescribed quantity or prescribed type ofthe medicine for inspection; and a collation means for collating theprescription information obtained by the prescription informationacquisition means with detected information acquired by the medicineinformation detector.
 10. The medicine inspection device according toclaim 1, wherein the medicine inspection device is to be connected to amedicine packaging device, the medicine packaging device comprising: amedicine supplier capable of supplying a medicine according toprescription; a medicine preparation means comprising a dispenser forstoring a medicine supplied by the medicine supplier by one dose and fordispensing the medicine; a packaging means for packaging the one dosesupplied from the medicine preparation means; and an outlet fordischarging a medicine packaged by the packaging means, the medicineinspection device further comprising a connector for connecting with theoutlet.
 11. The medicine inspection device according to claim 1, whereinmedicines are supplied as a continuous array of sachets formed bypackaging one dose of the medicine per sachet in a packaging paper andaligning the sachets in form of a strip, and each sachet is able to beinspected one by one, the medicine inspection device further comprisinga transportation means for delivering the continuous array of sachets tothe inspection unit while oscillating in the horizontal direction. 12.The medicine inspection device according to claim 11, wherein medicinesare supplied as a continuous array of sachets formed by packaging onedose of the medicine per sachet in a packaging paper and aligning thesachets in form of a strip, and each sachet is able to be inspected oneby one, the medicine inspection device further comprising: anintroduction unit for introducing the continuous array of sachets; atransportation means for delivering the continuous array of sachetsintroduced from the introduction unit; and an ejection unit for ejectingthe continuous array having passed through the inspection unit, whereina fixing device capable of stopping a movement of the continuous arrayof sachets by the transportation means to a transportation direction isprovided in the introduction unit or in the ejection unit or in both,and when oscillating the continuous array of sachets in the horizontaldirection, at least one end of the continuous array of sachets isfixable by the fixing device.
 13. The medicine inspection deviceaccording to claim 12, wherein the fixing device is configured tosandwich the continuous array of sachets.
 14. The medicine inspectiondevice according to claim 1, wherein medicines are supplied as acontinuous array of sachets formed by packaging one dose of the medicineper sachet in a packaging paper and aligning the sachets in form of astrip, and each sachet is able to be inspected one by one, the medicineinspection device further comprising: a transportation means fortransferring the continuous array of sachets to the inspection unit; andan upright-state elimination means provided in an upstream side of thetransportation direction of the continuous array of sachets with respectto the inspection unit, wherein the upright-state elimination meanscomprises an arm configured to oscillate along a surface of thecontinuous array of sachets passing through a transportation route ofthe transportation means.
 15. The medicine inspection device accordingto claim 14, wherein the arm comprises a roller capable of contacting asurface of the continuous array of sachets, and the roller is providedsubstantially all along a width direction of the transportation routeformed by the transportation means.
 16. The medicine inspection deviceaccording to claim 14, wherein the arm provided in the upright-stateelimination means comprises a contact part capable of contacting asurface of the continuous array of sachets, the contact part comprising:an introduction-side inclined surface inclining toward an introductionunit; an ejection-side inclined surface inclining toward an ejectionpart; and a medicine leveling unit provided in a boundary between theintroduction-side inclined surface and the ejection-side inclinedsurface; the medicine leveling unit comprising: a spindle provided alonga ridge line formed by the introduction-side inclined surface and theejection-side inclined surface; and a bead member equipped so as to beable to oscillate with respect to the spindle.
 17. The medicineinspection device according to claim 16, wherein, if a detection resultobtained by the medicine information detector for each sachet in thecontinuous array of sachets and the prescription information for thesachet are different, the sachet for which the detection informationdiffers from the prescription information is sent in the reversedirection by the upright-state elimination means and the continuousarray of sachets is reciprocated in a range in which the upright-stateelimination means contacts with the surface of the sachet.
 18. Themedicine inspection device according to claim 1, wherein medicines aresupplied as a continuous array of sachets formed by packaging one doseof the medicine per sachet in a packaging paper and aligning the sachetsin form of a strip, and each sachet is able to be inspected one by one,the medicine inspection device further comprising: a transportationmeans for transferring the continuous array of sachets to the inspectionunit; and an upright-state elimination means provided in an upstreamside of the transportation direction of the continuous array of sachetswith respect to the inspection unit, wherein the upright-stateelimination means comprises: a spindle provided above a transportationroute of the transportation means and along width direction oftransportation route; an arm equipped so that the arm is capable ofoscillate around the spindle; a bias means for biasing the arm towardsthe transportation path so as to let the arm contact with a continuousarray of sachets on the transportation path.
 19. The medicine inspectiondevice according to claim 1, wherein medicines are supplied as acontinuous array of sachets formed by packaging one dose of the medicineper sachet in a packaging paper and aligning the sachets in form of astrip, and each sachet is able to be inspected one by one, the medicineinspection device further comprising: a transportation means fortransferring the continuous array of sachets to the inspection unit; anupstream-side sensor provided in upstream side of the transportationdirection of the transportation means with respect to the inspectionunit; and a downstream-side sensor provided in downstream side of thetransportation direction of the transportation means with respect to theinspection unit, wherein when introducing the continuous array ofsachets, the continuous array of sachets is transported by thetransportation means through a location of the upstream-side sensor andthe inspection unit toward a location of the downstream sensor, and oncondition that the continuous array of sachets is detected by thedownstream-side sensor, the transportation means is configured toreverse a transportation direction of the continuous array of sachets bythe transportation means and let the continuous array for inspection toreach the inspection unit.
 20. The medicine inspection device accordingto claim 1, wherein medicines are supplied as a continuous array ofsachets formed by packaging one dose of the medicine per sachet in apackaging paper and aligning the sachets in form of a strip, and eachsachet is able to be inspected one by one, the medicine inspectiondevice further comprising: a transportation means for transferring thecontinuous array of sachets to the inspection unit; and an upright-stateelimination means provided in an upstream side of the transportationdirection of the continuous array of sachets with respect to theinspection unit and capable of oscillating along a surface of thecontinuous array of sachets, wherein the continuous array of sachets istransported to the inspection unit while being oscillated in horizontaldirection, and the upright-state elimination means is configured to falldown a medicine packaged in the sachet in an upright state during atransportation process to the inspection unit.
 21. The medicineinspection device according to claim 1, wherein medicines are suppliedas a continuous array of sachets formed by packaging one dose of themedicine per sachet in a packaging paper and aligning the sachets inform of a strip, and each sachet is able to be inspected one by one,wherein each of the sachets is sealed with a longitudinal seal partalong a width direction of the continuous array of sachets and a lateralseal part along a longer direction of the continuous array of sachets,and a boundary is formed between longitudinal seal parts of neighboringsachets in the continuous array of sachets, the medicine inspectiondevice further comprising: a shooting means for detecting positionprovided so as to be able to photograph the longitudinal seal partlocated at both sides of the boundary in a longer direction of thecontinuous array of sachets, the shooting means capable of photographingthe supplied continuous array of sachets in a predetermined position: alongitudinal seal position detecting means capable of obtaining alocation information of each longitudinal seal part appearing in animage area photographed by the shooting means for detecting position; aboundary position detection means capable of deriving position of theboundary by calculating an intermediate value of position information ofeach of longitudinal seal parts detected by the longitudinal sealposition detecting means; and a position identification means foridentifying position of sachet with respect to the inspection unit basedon position of the boundary derived by the boundary position detectionmeans.
 22. The medicine inspection device according to claim 1, whereina medicine is supplied in form of continuous array of sachets in which aplurality of sachets are aligned in form of a strip and each of thesachets is formed by sealing packaging paper, and a longitudinal sealpart is provided at least between neighboring sachets, and a dot-shapedseal trace is formed in the longitudinal seal part, and each sachet isable to be inspected one by one, the medicine inspection device furthercomprising a boundary position detection means capable of deriving aposition of the boundary, wherein the boundary position detection meansis configured to derive the position of the boundary by implementing: anoutline detection process for detecting an outline present in an imagearea of the sachets photographed by the shooting means; an outlineexpansion process for expanding a detected area surrounded by an outlinedetected by the outline detection process toward outside in apredetermined amount; a longitudinal seal area detection process fordetecting a longitudinal area, the longitudinal area being an areacomprising a plurality of detected areas which is mutually overlapped byexpansion in an image after the outline expansion process, and thelongitudinal area elongating along a longitudinal seal direction; and aboundary position derivation process for deriving an intermediateposition of the longitudinal seal area as a position of the boundary.23. The medicine inspection device according to claim 22, wherein acontent image removal process is implemented before the longitudinalseal area detection process and content packaged in packaging paper isrecognized based on luminance information and/or color information of animage for deriving a position of the boundary and image informationcorresponding to the content is removed.
 24. The medicine inspectiondevice according to claim 1, wherein medicines are supplied as acontinuous array of sachets formed by packaging one dose of the medicineper sachet in a packaging paper and aligning the sachets in form of astrip, and each sachet is able to be inspected one by one, wherein eachof the sachets is sealed with a longitudinal seal part along a widthdirection of the continuous array of sachets and a lateral seal partalong a longer direction of the continuous array of sachets, and aboundary is formed between longitudinal seal parts of neighboringsachets in the continuous array of sachets, the medicine inspectiondevice further comprising a boundary position detection means capable ofderiving position of the boundary, wherein the boundary positiondetection means is configured to implement: a longitudinal edgedetection process for detecting the longitudinal edge, the longitudinaledge being an outline elongating longitudinally in an image area of thesachets photographed by the shooting means; a longitudinal edgeselection process for selecting a longitudinal edge longer than apredetermined length from the longitudinal edge derived from thelongitudinal edge detection process; an edge area recognition processfor recognizing an area where a distance between longitudinal edgesselected by the longitudinal edge selection process is equal to orshorter than a predetermined distance set based on a width oflongitudinal seal part; and a boundary position recognition process forrecognizing a central part of the edge area recognized by the edge arearecognition process as a boundary position between the longitudinal sealparts.
 25. The medicine inspection device according to claim 1, whereinmedicines are supplied as a continuous array of sachets formed bypackaging one dose of the medicine per sachet in a packaging paper andaligning the sachets in form of a strip; a vacant sachet not containingmedicine is provided in an intermediate part of the continuous array ofsachets; an identification mark is put on a predetermined position ofthe vacant sachet; and each sachet is able to be inspected one by one,the medicine inspection device further comprising an identification markrecognition means capable of recognizing the identification mark havingarrived at a predetermined readout position present in the inspectionunit or an upstream side of supply direction of the continuous array ofsachets from the inspection unit, wherein a sachet containing medicineand positioned in a downstream side of the vacant sachet is locatableagainst the inspection unit based on the recognition position where theidentification mark is recognized by the identification mark recognitionmeans.
 26. A medicine packaging device comprising: the medicineinspection device described in claim 1; a medicine supplier capable ofsupplying a medicine according to a prescription; and a medicationpreparation means capable of gathering the medicine supplied from themedicine supplier for each package and dispensing the medicine; whereina quantity of medicine dispensed from the medication preparation meansis able to be inspected by the medicine inspection device.